Clinical trials: Aldosteronism
Primary Aldosteronism, Primary Hyperaldosteronism
Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
Primary aldosteronism (PA) is the most frequent form of secondary hypertension. It is caused by autonomous secretion of aldosterone, encompassing a group of disorders which is for 99% predominated by unilateral…
- Trial name
- PAGODE (NCT01728493)
- Where
- Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hyperaldosteronism; Primary, Hypertension Secondary
Primary Aldosteronism In Hypertensive Patients in China
To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with newly diagnosed hypertension.
- Trial name
- PA-China (NCT03155139)
- Testing
- Aldosterone/renin ratio (ARR) testing, Confirmatory tests
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Qifu Li
Hyperaldosteronism, Hypercortisolism
Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism
Background: The adrenal glands are 2 small organs that sit on top of each kidney. They release hormones; these are chemicals that control how the body works.
- Conditions
- Hyperaldosteronism, Hypercortisolism, Cushing s Syndrome
- Trial name
- NCT06246357
- Testing
- [68Ga]Ga-PentixaFor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Type 2 Diabetes, Chronic Kidney Diseases
Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease
The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.
- Trial name
- SubPA-DKD (NCT06190158)
- Testing
- Oral sodium suppression test, Saline suppression test, Captopril suppression test
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism, Hypertension
Adrenal Artery Ablation Treats Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common cause of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT03398785
- Testing
- Endovascular chemical Ablation of Adrenal Gland
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Third Military Medical University
Hyperaldosteronism
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)
This study evaluates if : 1 ) the plasma aldosterone concentration and blood pressure change in response to roxithromycin could be useful for the screening of PA patients carrying a KCNJ5-mutated APA; 2) the change of PAC in…
- Trial name
- MAPA (NCT03414918)
- Testing
- Clarithromycin
- Where
- Italy
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Primary Aldosteronism
AVS After 1mg DST to Determine Subtype in PA
To compare the effect of different procedures of AVS(after 1mg DST or not) in determining the subtypes and long-term outcomes of PA
- Trial name
- NCT04709185
- Testing
- Dexamethasone 1 MG Oral Tablet
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shanghai Zhongshan Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Bartter Syndrome
Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome
In this prospective controlled cross over clinical trial, the investigators aim to evaluate the efficacy and safety of acetazolamide for the management of metabolic alkalosis in children with Bartter syndrome.
- Trial name
- AZ (NCT03847571)
- Testing
- Acetazolamide
- Where
- 4 sites in Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Hypertension, Dialysis
Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?
It is well known that Aldosterone (aldo) can cause hypertension (HBP). Since aldo is known to cause the kidney to retain sodium (Na) and Na retention is known to cause HBP, it has been thought that the mechanism by which aldo…
- Conditions
- Hypertension, Dialysis, Hyperaldosteronism
- Trial name
- NCT00553722
- Testing
- Eplerenone
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- Shaare Zedek Medical Center
Hyperaldosteronism; Primary
Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of the Aldosterone / Renin Ratio for the Diagnosis of Primary Hyperaldosteronism
collaborative work within 2 hospitals at the CHU of Caen, at the CHRU of Lille, concerning the evaluation of the biological markers of primary hyperaldosteronism (PAH) with the dosage of aldosterone in LC -MS/MS, which is…
- Trial name
- DAPS (NCT05640128)
- Testing
- Aldosterone in HPLC-MS/MS
- Where
- France
- Volunteers
- 105 people
- Sponsor
- University Hospital, Caen
Nonfunctional Adrenal Cortex Adenoma, Primary Aldosteronism
A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery
The goal of this clinical trial is to exploring the role of tubeless after adrenalectomy surgery. The main questions it aims to answer are: 1. The safety of tubeless laparoscopic adrenalectomy； 2.
- Conditions
- Nonfunctional Adrenal Cortex Adenoma, Primary Aldosteronism, Cushing Syndrome
- Trial name
- NCT06250699
- Testing
- Tubeless laparoscopic adrenalectomy, Drainage tube
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhe Meng
Hypertension, Primary Aldosteronism
Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
This is an observational study compares the positivity rates of two tests for screening for primary aldosteronism: plasma aldosterone renin ratio and 24-hour urine aldosterone in patients with young-onset hypertension with or…
- Conditions
- Hypertension, Primary Aldosteronism, Urine Aldosterone
- Trial name
- PURL (NCT06047912)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Dr Ian B Wilkinson
Hypertension
The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex.
- Trial name
- NCT01996449
- Testing
- Eplerenone, Amlodipine, Microneurography
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Mild Cognitive Impairment (MCI)
Nutritional Intervention With the Dietary Supplement, Immunocal® in MCI Patients: Promotion of Brain Health
Alzheimer disease (AD) is a dementing illness characterized by progressive neuronal degeneration, gliosis, and the accumulation of intracellular inclusions and extracellular deposits of amyloid in discrete regions of the basal…
- Trial name
- NCT03448055
- Testing
- Immunocal
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Immunotec Inc.
Primary Aldosteronism, Hypertension
Effects of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common cause of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT04409431
- Testing
- Endovascular chemical Ablation of Adrenal Gland
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Autonomous Cortisol Secretion
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS).
- Conditions
- Primary Aldosteronism, Autonomous Cortisol Secretion, Adrenal Insufficiency
- Trial name
- NCT06955286
- Testing
- complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
- Where
- China
- Volunteers
- 521 people
- Sponsor
- Qifu Li
Primary Aldosteronism, Hypertension
Adrenal Artery Ablation for Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common causes of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT03653845
- Testing
- Endovascular chemical Ablation of Adrenal Gland, Sequenced antihypertensvie drugs with titrated dosage
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Third Military Medical University
Adrenalectomy; Status
Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism
To evaluate long-term results of adrenalectomy for primary aldosteronism (PA) and to identify prognostic factors associated. Exhaustive retrospective review of all consecutive patients undergoing adrenalectomy for PA between 2002…
- Trial name
- Hyperaldo (NCT03648294)
- Testing
- adrenalectomy for primary addosteronism
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Primary Hyperaldosteronism, Hypertensive Disorder of Pregnancy
HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Trial)
Primary hyperaldosteronism confers a higher risk of cardiovascular complications compared to essential hypertension. Preliminary data is controversial in regards of excessive maternal fetal and neonatal excessive risks in…
- Trial name
- NCT05636995
- Testing
- Aldosterone/Renin Ratio
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke