Clinical trials: Aldosteronism
Primary Aldosteronism
Nuclear Imaging for Subtype Diagnosis of Primary Aldosteronism
This study is to evaluate the accuracy of a novel radiopharmaceutical tracer, para-chloro-2-[18F]fluoroethyl etomidate (CETO), used with positron emission tomography (PET) and computed tomography (CT), as a way to subtype…
- Trial name
- NCT05472493
- Testing
- [18-F]CETO
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
To evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of primary aldosteronism concurrent with autonomous cortisol secretion patient, using AVS and/or postoperative remission as the reference standard…
- Trial name
- ABOARD (NCT06635993)
- Testing
- 68Ga-Pentixafor PET/CT
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Qifu Li
Primary Aldosteronism
Short- and Long-term Outcomes of Adrenalectomy for Primary Aldosteronism
The proposed study is this. Short- and long-term outcomes of adrenalectomy for Primary Aldosteronism (PA) in a single centre. PA is a relatively common problem and considers as the commonest cause of secondary hypertension and…
- Trial name
- NCT06192810
- Testing
- Laparoscopic/open adrenalectomy
- Volunteers
- 84 people
- Sponsor
- University College London Hospitals
Primary Aldosteronism
Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity
Background: The most common pharmacologic test for diagnosis of primary aldosteronism (PA) is administration of captopril to examine whether abnormal aldosterone to plasma rennin activity (PRA)(ARR) persists, although active…
- Trial name
- NCT00917345
- Testing
- captopril test
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Choroidal Neovascularization, Mineralocorticoid Excess
Biomarkers and Choroidal Neovascularization
The aim of the study is to find biomarkers in the blood and aqueous humor of patients with type 1 choroidal neovascularization and correlate them with the response to anti-VEGF treatment.
- Trial name
- BioNéoRet (NCT04439708)
- Testing
- Blood and aqueous humor biomarker of treatment response
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Adrenal Insufficiency, Cushing Syndrome
Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have…
- Conditions
- Adrenal Insufficiency, Cushing Syndrome, Hyperaldosteronism
- Trial name
- SensoCort (NCT06008184)
- Testing
- 24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva), 24 hours sampling of ISF or sweat (after validating the correlation with blood)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Primary Aldosteronism
Renal Cysts and Primary Aldosteronism
During routine subtyping of confirmed primary aldosteronism by adrenal vein sampling extra plasma samples are drawn from both renal veins and from inferior vena cava.
- Trial name
- NCT05435703
- Where
- Finland
- Volunteers
- 115 people
- Sponsor
- Tampere University Hospital
Resistant Hypertension, Secondary Hypertension
Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization
To explore the relationship between perioperative blood pressure and catecholamine concentrations in adrenal venous blood and peripheral venous blood in hypertensive patients with primary aldosteronism (PA) who underwent…
- Conditions
- Resistant Hypertension, Secondary Hypertension, Secondary Hypertension to Endocrine Disorders, Primary Aldosteronism
- Trial name
- NCT06228677
- Testing
- Selective adrenal artery embolization
- Where
- China
- Volunteers
- 196 people
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate
10% of patients with hypertension potentially have the treatable condition - primary aldosteronism. Primary aldosteronism (PA) is caused by either bilateral adrenal disease (~40%), managed with lifelong medications; or unilateral…
- Trial name
- NCT03990701
- Testing
- 11C-Metomidate PET/CT Scan
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism
Open-label Study on Treatment of Primary Aldosteronism With Everolimus
The overall objective is to evaluate everolimus as an aldosterone-lowering drug in the treatment of primary hyperaldosteronism.
- Trial name
- NCT03174171
- Testing
- Everolimus 0.75 mg
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Basel, Switzerland
Primary Hyperaldosteronism, Electrolyte Disturbance
Tissue K+ in Primary Hyperaldosteronism
Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism.
- Trial name
- NCT04251780
- Testing
- Surgical Treatment of Primary Aldosteronism, Drug treatment of Primary Aldosteronism
- Where
- 2 sites in Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Primary Aldosteronism, Hypertension
Comparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary Aldosteronism
Primary aldosteronism (PA) is thought to be the most common secondary endocrine form of hypertension. Compared with patients with essential hypertension with similar blood pressure, patients with PA have significantly higher…
- Trial name
- NCT05814770
- Testing
- Finerenone, Spironolactone
- Volunteers
- 96 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Primary Aldosteronism
Untargeted Metabolomics for Primary Aldosteronism
Primary aldosteronism (PA) is a common and likely under-diagnosed cause of secondary hypertension with associated cardiovascular morbidity and mortality.
- Trial name
- PUMPAP (NCT06076473)
- Testing
- Untargeted metabolomics
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Spatial Proteomics Profiles of Aldosterone-producing Adenoma and Unilateral Hyperplasia
Primary aldosteronism (PA) is a common cause of secondary hypertension, which is characterized by excessive aldosterone production by the adrenal gland.
- Trial name
- NCT05927961
- Testing
- histopathology
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Military Medical University
Hyperaldosteronism; Primary, Hypertension
Investigating Salt Taste Threshold in Patients Being Investigated for Primary Hyperaldosteronism Before and After Treatment.
This study looks at how hypertensive patients, with high levels of aldosterone (hyperaldosteronism) differ from hypertensive patients without hyperaldosteronism with regards to markers of salt appetite.
- Conditions
- Hyperaldosteronism; Primary, Hypertension, Salt; Excess, Appetite Disorders
- Trial name
- AldoSalt (NCT04556279)
- Testing
- adrenalectomy, Aldosterone Antagonist
- Where
- United Kingdom
- Sponsor
- Imperial College London
Primary Aldosteronism
Aldosterone Renin Ratio (ARR) Test to Increase Case-detection of Primary Aldosteronism (PA)
The mission of this project is to increase the detection of Primary Aldosteronism (PA), the most common cause of secondary hypertension, which can either be cured surgically or treated with targeted medications.
- Trial name
- ARR (NCT05757076)
- Testing
- Blood test for ARR
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- The Cleveland Clinic
Primary Aldosteronism
Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism
To study the efficacy and safety of finerenone in patients with primary aldosteronism
- Trial name
- NCT05924620
- Testing
- finerenone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chongqing Medical University
Aldosterone-Producing Adenoma
CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis
The goal of this clinical trial is to evaluate the effectiveness of CXCR4 targeted PET imaging in preoperative localization diagnosis of primary aldosteronism (PA).
- Trial name
- NCT05839483
- Testing
- CXCR4
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Hypertension, Primary Aldosteronism
Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism
To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening and confirmatory test, and to determine the appropriate diagnostic cutoff value for Chinese hypertension patients during…
- Trial name
- HASA (NCT04991961)
- Testing
- withdraw antihypertensive drugs
- Where
- 2 sites in China
- Volunteers
- 341 people
- Sponsor
- Chongqing Medical University