Clinical trials: Aldosteronism
Primary Aldosteronism
Primary Aldosteronism: Prospective Screening Registry in China
1. Study name: A prospective study of the incidence and outcomes of Primary aldosteronism in Chinese hypertensive patients 2. Rationale: Unlike essential hypertension, secondary hypertension is caused by certain defined diseases…
- Trial name
- NCT04020783
- Testing
- NO Intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Primary Aldosteronism
Prognosis of Primary Aldosteronism: A Prospective Cohort Study
Primary aldosteronism (PA) is the most common cause of secondary hypertension, and patients with PA have a significantly higher risk of developing cardiovascular and renal complications compared with those with essential…
- Trial name
- PA-PROG (NCT07378176)
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism
DP13 - A Phase II Study in Patients With Primary Aldosteronism
The purpose of the present phase II study is to determine whether DP13 displays the clinical safety and efficacy profile to support further development in patients with primary aldosteronism.
- Trial name
- NCT04007406
- Testing
- dexfadrostat phosphate
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Damian Pharma AG
Primary Aldosteronism
The Comparison of Single Catheter and Double Catheter Adrenal Vein Sampling Methods Based on the Upper Limb Approach
Primary Aldosteronism (PA) is a clinical syndrome characterized by the autonomous overproduction of aldosterone by the adrenal cortex's zona glomerulosa, leading to hypertension, elevated aldosterone levels, and suppressed renin…
- Trial name
- NCT06737848
- Testing
- Single catheter adrenal vein sampling, Double catheters adrenal vein sampling
- Volunteers
- 70 people
- Sponsor
- Army Medical University, China
Primary Aldosteronism
Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study
This research focuses on the prevalence of Primary Aldosteronism in the Malaysian adult population.
- Trial name
- MyEndo-PA (NCT02257450)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- International Islamic University Malaysia
Hypertension
Omics Signature in the Diagnosis of Hypertension
The purpose of this study is to assess the validity and usefulness of omics signatures for improved identification and risk stratification of patients with endocrine hypertension and stratification of patients with primary…
- Trial name
- ENSAT-HT (NCT02772315)
- Testing
- omics
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 4,000 people
- Sponsor
- Radboud University Medical Center
Primary Aldosteronism
Study on Postoperative Adrenal Function Assessment in Patients With Primary Aldosteronism
This study employs a prospective, single-center, open, observational research design to evaluate postoperative adrenal cortical function in patients with primary aldosteronism (PA) and to explore indicators predicting…
- Trial name
- NCT06534268
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Atrial Fibrillation, Sleep Apnea
Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities
Pulmonary vein isolation is an established intervention for atrial fibrillation. Patients with a paroxysmal atrial fibrillation have no or only few comorbidities and a good prognosis in respect to their atrial fibrillation.
- Conditions
- Atrial Fibrillation, Sleep Apnea, Primary Aldosteronism
- Trial name
- PAfOSAS (NCT07857044)
- Testing
- Screening on comorbidites
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Christina Berr. MD
Primary Aldosteronism, Hypertension
Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary Aldosteronism
The goal of this observational study is to learn about the optimal dose of spironolactone treatment and the long-term outcomes on cardiovascular and cerebrovascular events in patients with lateralized PA who are unwilling to…
- Trial name
- NCT07137364
- Testing
- spironolactone
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Endocrine Hypertension
Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism
The goal of this pilot, open-label prospective study is to evaluate if the effect of calcium channel blockade on plasma aldosterone levels in people with primary aldosteronism (PA) is due primarily to Cav1.3 blockade.
- Trial name
- NCT05686993
- Testing
- Cinnarizine, NIFEdipine ER
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen Mary University of London
Hyperaldosteronism
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism
The tissue kallikrein-kinin (KKS) and renin-angiotension-aldosterone system (RAAS) had been implicated in regulating blood pressure and electrolyte homeostasis.
- Trial name
- NCT00155064
- Testing
- captopril, Losartan (drug)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Primary Hyperaldosteronism
Intraoperative Analysis of Cortisol During Adrenal Vein Sampling
Aldosterone is a hormone produced in the adrenals that helps regulate the salt balance and blood pressure. Primary hyperaldosteronism is one of the main endocrine causes of secondary hypertension.
- Trial name
- NCT01761344
- Testing
- Intraoperative cortisol measurement.
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Haukeland University Hospital
Primary Aldosteronism
Optimizing Diagnosis Of Primary Aldosteronism
To optimize the confirmatory tests for primary aldosteronism.
- Trial name
- ODPA (NCT02755519)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism, Statin
Statin Combined with Amlodipine Treats Primary Aldosteronism
The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1…
- Conditions
- Primary Aldosteronism, Statin, Mineralocorticoid Receptor Antagonist, Hypertension
- Trial name
- STOP-PA (NCT06523465)
- Testing
- Simvastatin combined with Amlodipine besylate, Simvastatin combined with Spironolactone and Amlodipine besylate., Amlodipine besylate combined Spironolactone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
Study of QLS1410 in the Treatment of Primary Aldosteronism.
This is a Phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety, tolerability, and efficacy of QLS1410 versus placebo, on the reduction of Seated Blood Pressure (SBP) in…
- Trial name
- NCT07550465
- Testing
- QLS1410
- Volunteers
- 60 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Primary Aldosteronism
Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism
The present study was undertaken prospectively to compare the diagnostic significance of the seated saline suppression testing (SSST) with the captopril challenge testing (CCT) in hypertensive patients with suspected primary…
- Trial name
- NCT03500120
- Testing
- Seated saline infusion test
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chongqing Medical University
Aldosteronism
Establishment of Aldosterone and Renin Reference Range
Elevated aldosterone levels were also shown to contribute to the excess morbidity and mortality. Literature shows aldosterone and renin levels differ between ethnicity and gender.
- Trial name
- ARR (NCT05232162)
- Where
- Malaysia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Primary Aldosteronism
Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism
This study is to evaluate the performance characteristics of the seated saline infusion test and the ultra low-dose ACTH stimulation test for the diagnosis of primary aldosteronism.
- Trial name
- NCT04422756
- Testing
- Seated intravenous saline infusion test, Ultra low-dose ACTH stimulation test
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University