Clinical trials: Algorithms
Heart Failure NYHA Class III and Ambulatory IV
Clinical Trial of the SonRtip Lead and Automatic AV-VV Optimization Algorithm in the PARADYM RF SonR CRT-D
The objective of this study is to assess the safety and effectiveness of the automatic atrioventricular (AV) delay and interventricular (VV) delay optimization algorithm used in the PARADYM RF SONR Cardiac Resynchronization…
- Trial name
- RESPOND-CRT (NCT01534234)
- Testing
- PARADYM RF SONR
- Where
- 125 sites in United States, Australia and 10 more
- Volunteers
- 1,039 people
- Sponsor
- MicroPort CRM
Critical Illness
Usability of Blood Glucose Control With the Space TGC System in Medical ICU Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Thus, glycaemic control is an important issue in critical care.
- Trial name
- DELIOS 4 (NCT01164449)
- Testing
- Space TGC
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Stress, Emotional Wellbeing
Prospective Real World Study on Therapy Prediction Algorithm Training
This study examines the impact of using an algorithm to select therapy content for patients engaged with the mobile mental health platform AmDTx (Mobio Interactive).
- Trial name
- NCT06265909
- Testing
- AmDTx
- Where
- Singapore
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Mobio Interactive PTE LTD
Hyperglycemia, Cardiac Surgery
Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients
The purpose of this study is to evaluate the safety and efficacy of a system combining continuous glucose measurement with a computer-based algorithm for insulin delivery in patients undergoing elective cardiac surgery.
- Trial name
- NCT00996099
- Testing
- Continuous glucose monitoring system combined with enhanced model predictive control algorithm for intensive insulin treatment, Intensive insulin therapy using standard protocol
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Charles University, Czech Republic
Postoperative Pulmonary Complications
Different Algorithm Models to Predict Postoperative Pulmonary Complications in Elderly Patients
Although a number of clinical predictive models were developed to predict postoperative pulmonary complications, few predictive models have been used in elderly patients.
- Trial name
- NCT05671939
- Volunteers
- 10,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Abdominal Injuries, Thoracic Injuries
TRACT Study: Evaluation of the Value of Routine Thoraco-abdominal CT in Blunt Trauma Patients
The aim of this study is to establish the additional effectiveness and costs of routine thoraco-abdominal computed tomography (CT) in blunt trauma patients versus conventional radiological imaging and to determine which clinical…
- Trial name
- NCT00228111
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Radboud University Medical Center
Melanoma, Moles
FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA)
All patients will undergo dermoscopic diagnosis and be documented with a video image storing. The diagnosis based on dermoscopy will be immediately documented.
- Trial name
- FLIMMA (NCT02425475)
- Testing
- LIMES
- Where
- 3 sites in Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
Improving Medication Safety for Kidney Disease With a Digital Drug Dosing Tool in Nova Scotia Community Pharmacy Practice.
Chronic kidney disease (CKD) is a common condition. It occurs in approximately 7 out of 100 Canadians and is highest in rural settings. The kidneys are responsible for the removal of many drugs from the body.
- Trial name
- NCT06820372
- Testing
- Electronic Drug Dosing and Decision Support Kidney (eDoseCKD) Tool
- Volunteers
- 125 people
- Sponsor
- Nova Scotia Health Authority
Coagulation Disorder, Blood
Blood Transfusion and Postoperative Outcome Before and After Implementing a Coagulation Management Algorithm
Implementing coagulation management algorithms based on Point-of-care (POC) testing devices such as thromboelastography (TEG) or rotational thromboelastometry (ROTEM) have been shown to reduce transfusion rates and the occurrence…
- Trial name
- SONALG (NCT03482128)
- Testing
- Coagulation management guided by SONOCLOT, Standard coagulation management
- Where
- Switzerland
- Volunteers
- 1,754 people
- Sponsor
- Triemli Hospital
Ampulla of Vater Carcinoma, Appendix Carcinoma
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for cancer in the gastrointestinal system compared to usual care.
- Conditions
- Ampulla of Vater Carcinoma, Appendix Carcinoma, Carcinoma of Unknown Primary With Gastrointestinal Profile, Colon Carcinoma
- Trial name
- NCT07283939
- Testing
- PAGODA algorithm, Oxaliplatin, Folinic Acid
- Where
- 368 sites in United States, Guam and 1 more
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Fever
Fever Algorithm Development of a Non-invasive Wearable Core Body Temperature Sensor System in Intensive Care Unit Patients
Background and Rationale: The gold standard to assess fever, is to conduct invasive intravascular, esophageal or bladder thermistor core body temperature (CBT) measurements.
- Trial name
- NCT04182945
- Testing
- Data collection for algorithm development
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- greenTEG AG
Atherosclerotic Plaque
Reduced Radiation Dose and IR-impact on Coronary Calcium Quantification
Evaluation of reduced radiation dose iterative reconstruction reconstructions for calcium scoring compared to full dose filtered back projection reconstructions
- Trial name
- NCT04267094
- Testing
- Iterative reconstruction at reduced radiation dose
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Pennsylvania
Pregnancy
Clinical Data Collection for Obstetric Ultrasound Algorithms
The goal of this clinical trial is to Collect ultrasound data from pregnant and non-pregnant individuals presenting to multiple study sites.
- Trial name
- MOBUS (NCT06742229)
- Testing
- Research Ultrasound scan
- Where
- 3 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Caption Health, Inc.
Diabetes
Artificial Pancreas in Latin America
The purpose of this study is to use closed-loop systems with the algorithms designed by the University of Virginia and by the Instituto Tecnologico de Buenos Aires (ITBA)/ Universidad Nacional de La Plata (UNLP)/ Universidad…
- Trial name
- NCT02994277
- Testing
- 1° Phase: UVa algorithm 2° Phase: ITBA/UNLP algorithm
- Volunteers
- 5 people
- Sponsor
- Hospital Italiano de Buenos Aires
Cardiac Arrhythmias
Assessing the Predictive Value of High Frequency Algorithm of PURE EP for Low Amplitude Signal Detection
Prior multicenter study demonstrated superiority of PURE EP to conventional mapping. This superiority was seen when comparing small, fractionated signals of interest, near-field vs far-field distinction, and general signal…
- Trial name
- NCT05450302
- Testing
- PURE EP (Observational Study)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
HIV, Depression
IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV
IMPAACT 2002 is a prospective, multi-site, two-arm, cluster-randomized study to evaluate whether a health and wellness Cognitive Behavioral Therapy and Medication Management (COMB-R) intervention for depression demonstrates…
- Trial name
- NCT02939131
- Testing
- Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithm, Enhanced Standard of Care
- Where
- 13 sites in United States
- Volunteers
- 156 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Cervical Cancer, HSIL
Development and Evaluation of an Artificial Intelligence Tool for Colposcopy Assistance
Project aiming to develop an algorithm to help the interpretation of colposcopy images, then to evaluate the effectiveness of this algorithm by using it on new cases and comparing the results obtained to the impression of expert…
- Conditions
- Cervical Cancer, HSIL, LSIL, Cervical Ectropion
- Trial name
- IACOL (NCT06208319)
- Testing
- data collection
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neovascular Age-related Macular Degeneration
Development of an Optimal Algorithm for the Management of Patients With Retinal Pigment Epithelium Detachment in Neovascular Age-related Macular Degeneration Using Artificial Intelligence
The study involves the development of an algorithm for predicting anatomical and functional results of therapy with angiogenesis inhibitors in patients with retinal pigment epithelium detachments in neovascular age-related…
- Trial name
- NCT05208931
- Testing
- Anti-vascular endothelial growth factor therapy
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Shock, Septic
Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test
A randomized controlled clinical trial to evaluate whether a passive leg raising test to guide fluid therapy of patients with septic shock can reduce fluid balance and weight gain.
- Trial name
- OFTaPLR (NCT02301585)
- Testing
- Passive Leg Raising Test, Standard of care
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska Institutet
Hemorrhage
Pre-emptive Hemodynamic Optimization of High Risk Patients Undergoing Elective Major Surgical Procedures
Several recent clinical trials have documented that early aggressive resuscitation approached guided by defined hemodynamic variables using thoughtful protocols may improve outcome.
- Trial name
- NCT00725972
- Testing
- Augment O2 Delivery by hemodynamic protocol, High Risk Surgery
- Where
- United States
- Sponsor
- University of Pittsburgh