Clinical trials: Aligner Therapy
Tooth Discoloration
Bleaching Procedures Performed During Treatment With Brackets and Clear Aligners
The aim of this study is to compare the effectiveness of different whitening methods used during orthodontic treatment with fixed appliances and clear aligners.
- Trial name
- NCT06716827
- Testing
- In-office bleaching system, Laser-assisted bleaching, Home-bleaching
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ahmet Yağcı
Mixed Dentition Using Sequential Dental Aligners
This Study Will Examine Shortened Treatment Wear Time for Patients With Mixed Dentition Using AirFlex Aligner, Sequential Dental Aligners.
This study will examine shortened treatment wear time for patients with mixed dentition using sequential dental aligners. Using the existing AirFlex aligner design that patients with permanent dentition use, it may be possible to…
- Trial name
- NCT07220317
- Testing
- Sequential Aligners
- Volunteers
- 45 people
- Sponsor
- OrthoFX
Malocclusion
FM Technique in Orthodontic Clear Aligner Therapy: A Single-Arm Clinical Study
This trial tests whether a new method (FM) for moving back teeth can shorten clear-aligner treatment. All participants use FM, which moves the canine and first molar back together instead of one tooth at a time like the standard…
- Trial name
- NCT07896369
- Testing
- Clear aligners with FM (Fluid Move) design
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
White Spot Lesion of Tooth
Impact of Lingual Attachment on WSL Development in Clear Aligner Patients: A Randomized Controlled Clinical Trial
White spot lesions (WSLs) are a common esthetic complication during orthodontic treatment. While clear aligners (CAs) generally reduce WSL risk compared to fixed appliances, composite attachments remain plaque-retentive sites.
- Trial name
- NCT07368296
- Testing
- Lingual attachment participants
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Root Resorption, Pain
Side Effects of Different Treatment Methods
this study aimed to compare the effects of fixed orthodontic treatment and clear aligner therapy on root resorption, periodontal status, pain experience and chewing performance.
- Conditions
- Root Resorption, Pain, Chewing Function
- Trial name
- NCT06709287
- Testing
- clear aligners, orthodontic metal bracket
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
White Spot Lesions, Demineralization
Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients
Background/ Objectives: Clear aligner attachments increase the risk of white spot lesions (WSL), with a 35.5% incidence in adolescents. The number of anterior attachments is an independent risk factor (OR=2.192).
- Conditions
- White Spot Lesions, Demineralization, Dental Caries, Orthodontic Treatment
- Trial name
- NCT07229105
- Testing
- GC Tooth Mousse, Nano-Hydroxyapatite Gel, Sodium Fluoride varnish
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
White Spot Lesions
The Effect of Nano Chitosan Surface Coating on White Spot Lesions Development in Clear Aligner Therapy Patients
In this study, it was intended to investigate the effect of nano Chitosan (antimicrobial agent) coating on clear aligner orthodontic appliance if it reduces the incidence of white spot lesions (demineralization) of enamel…
- Trial name
- NCT07715552
- Testing
- chitosan nanoparticles, No Treatment Added
- Where
- Jordan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Tooth Discoloration, Tooth Sensitivity
At-home Bleaching Using Clear Retainers
The aim of this project is to clinically evaluate patient satisfaction, whitening efficacy, tooth sensitivity, and gingival irritation during at-home whitening with 10% carbamide peroxide using an Essix-type retainer or a Vivera…
- Conditions
- Tooth Discoloration, Tooth Sensitivity, Gingivitis, Satisfaction, Patient
- Trial name
- NCT05835453
- Testing
- Whitening
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Clear Aligner Orthodontic Treatment, Composite Attachment
Tooth Discoloration and Chairside Handling Time (Bonding-Debonding) in Flowable Versus Packable Composites for Clear Aligner Bonded Attachments: A Randomized Clinical Trial
This randomized split-mouth clinical trial aims to compare two different composite materials used for bonding attachments in clear aligner orthodontic therapy.
- Conditions
- Clear Aligner Orthodontic Treatment, Composite Attachment, Color Stability of Enamel
- Trial name
- NCT07234149
- Testing
- flowable nanohybrid Composite Resin, Packable Microhybrid Composite Resin
- Where
- 2 sites in Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Juvenile Idiopathic Arthritis, Malocclusion, Angle Class II
Mandibular Advancement Clear Aligner Treatment in Juvenile Idiopathic Arthritis Subjects
There is currently no information on how mandibular advancement therapy could influence three-dimensionally the condylar and mandibular morphology in growing patients affected by Juvenile Idiopathic Arthritis (JIA).
- Trial name
- NCT05467579
- Testing
- Device: orthodontic - mandibular advancement clear aligner
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Genova
Dental Crowding,Interproximal Enamel Reduction, Malocclusion, Angle's Class
Accuracy and Periodontal Outcomes of Three Interproximal Enamel Reduction Techniques During Clear Aligner Therapy
This randomized controlled clinical trial will compare three commonly used interproximal enamel reduction (IPR) techniques during clear aligner therapy in adult patients.
- Conditions
- Dental Crowding,Interproximal Enamel Reduction, Malocclusion, Angle's Class, Periodontal Diseases
- Trial name
- NCT07377825
- Testing
- Manual Arm, Motor Driven Arm, Abrasive Arm
- Where
- Saudi Arabia
- Volunteers
- 75 people
- Sponsor
- Riyadh Elm University
Malocclusion, Esthetics, Dental
Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study
The goal of this clinical study is to learn whether the gumline edge design of a finishing orthodontic clear aligner affects how much the aligner's color changes after 14 days of wear.
- Trial name
- SPECTRO-ALIGN (NCT07628491)
- Testing
- Tri-layer thermoplastic finishing clear aligner
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Malocclusion, Pain
Anxiety, Pain, and Quality of Life in Orthodontic Treatment
This study was evaluated anxiety, pain, and oral health-related quality of life in individuals treated with conventional fixed appliances (Group A) and clear aligners (Group B) for moderate malocclusion during the initial phase…
- Conditions
- Malocclusion, Pain, Anxiety, Quality of Life
- Trial name
- NCT06133296
- Testing
- Conventional fixed treatment, Clear aligner treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Angle Class 2 Malocclusion
Clear Aligners vs Fixed Appliances for Molar Distalization Using Infrazygomatic Crest Screws
This study compares three different methods of moving upper back teeth backward (distalization) to create space for crowded or protruding teeth, all supported by small temporary screws placed in the cheekbone area (infrazygomatic…
- Trial name
- NCT07714603
- Testing
- Pitts21® fixed appliance, Invisalign® Clear Aligners, ClearCorrect Clear Aligners
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- TC Erciyes University
Plaque-Induced Gingivitis, Orthodontic Treatment
Clinical Outcomes of Different Mouth Rinses During Clear Aligner Orthodontic Therapy
This pilot randomized controlled clinical trial will evaluate the feasibility and preliminary clinical effects of three mouth rinses-alum, Triphala-based herbal mouth rinse, and 0.2% chlorhexidine-in adults undergoing clear…
- Trial name
- NCT07865416
- Testing
- Alum Mouth Rinse, Triphala-based Herbal Mouth Rinse, Chlorhexidine mouth rinse
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Manav Rachna International Institute of Research and Studies
Malocclusion, Angle Class II
Therapeutic Effects of Class II Elastics on Aligners in Different Vertical Skeletal Patterns
The objective is to compare the dento-alveolar therapeutic effects of wearing class II inter-arch traction elastics on aligners versus multi-brackets in an adult population.
- Trial name
- NCT05853211
- Testing
- Aligner and inter-arch elastics
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
White Spot Lesion
Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment
Development of white spot lesions (enamel demineralization) will be evaluated quantitatively during clear aligner orthodontic treatment compared to conventional fixed appliances using quantitative light induced fluorescence (QLF)
- Trial name
- NCT04107012
- Testing
- Orthodontic treatment with clear aligner
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Crowding, Malocclusion
Clear Aligners With Two Different Change Schedules vs Traditional Braces for People With Crowded Lower Front Teeth
The goal of this clinical trial was to compare two clear aligner treatment plans with traditional braces for treating crowded lower front teeth in adults. Clear aligners were removable plastic trays.
- Trial name
- NCT07821723
- Testing
- Clear aligner, 0.25 mm per step, Clear aligner, 0.35 mm per step, Conventional fixed orthodontic appliance
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Ain Shams University
Deep Bite Malocclusion
Efficacy of Aligners vs ABT and RCOS for Deep Bite Correction: CBCT Study
This prospective clinical trial aims to evaluate the efficacy of clear aligner therapy compared to two different treatment modalities - anterior bite turbos and reverse curve of Spee (RCOS) archwires - for the correction of…
- Trial name
- DB-CBCT (NCT07096401)
- Testing
- Reverse Curve of Spee Archwire, Anterior Bite Turbos, Clear Aligners
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Crowding of Anterior Mandibular Teeth
Evaluation of the Efficiency of Single Aligner Appliance for Treatment of Mild Crowding Cases in Adults.
36 participants who have mild crowding from the Orthodontic Department at University of Damascus Dental School will be randomly assigned into two groups. 1.
- Trial name
- NCT04988373
- Testing
- Modified aligner appliance, Traditional fixed appliance
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University