Clinical trials: Aligner Therapy
Angle's Class I Malocclusion, Crowding, Tooth
Effectiveness of Clear Aligners in Different Thicknesses
This study aimed to evaluate the effectiveness, pain, and satisfaction levels between patients treated with different thicknesses of clear aligners among Class I maxillary mild crowding cases.
- Trial name
- NCT06504498
- Testing
- 0.5 mm-thick Duran® clear aligner, 0.75 mm-thick Duran® clear aligner
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Mersin University
Unilateral Complete Cleft Lip and Palate
Printed Aligners for Nasoalveolar Molding Treatment
study will provide nasoalveolar molding (NAM) treatment, special care for infants born with cleft lip and palate. This novel appliance will help to provide the care in accurate and easy form by help of both digital work flow and…
- Trial name
- NAM (NCT06683560)
- Testing
- : photopolymer resin material "graphy" Tera Harz 85 will be used to print 3D printed aligners for NAM treatment
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Effect of Platelet Rich FibrinDuring Clear Aligner Therapy
Influence of Injectable Platelet Rich Fibrin on Different Orthodontic Tooth Movements During Clear Aligner Therapy
The aim of this prospective clinical project will be to assess the effect of platelet rich fibrin on the rate of different orthodontic tooth movements during clear aligner therapy.
- Trial name
- NCT06380946
- Testing
- iPRF
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Clear Aligner Therapy, Malocclusions
Evaluation of the Effect of Aligner Seaters on the Predictability of Tooth Movement in Clear Aligner Therapy.
The goal of clinical trial is to know the role clear aligner seater. The main question it aims to answer is to evaluate the use of clear aligner seater on the effectiveness of clear aligner therapy by questioning the…
- Trial name
- NCT07726485
- Testing
- Aligner seater
- Where
- Iraq
- Volunteers
- 34 people
- Sponsor
- University of Baghdad
Teeth Straightening, Aligner Therapy
A Study to Compare Nighttime Aligners to Daytime Aligners
The purpose of this research study is to see if Nighttime Aligners (worn 10-12 hours per day or night) are effective and safe for tooth movement and if so, how they compare with the standard Daytime aligners (worn 20-22 hours per…
- Conditions
- Teeth Straightening, Aligner Therapy, Orthodontic Aligner
- Trial name
- NCT06539676
- Testing
- Nighttime Aligners, Daytime Aligners
- Where
- 12 sites in United States
- Volunteers
- 7 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Periodontal Diseases, Malocclusion
Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During Orthodontic Treatment: A Split-Mouth Study.
The goal of this clinical trial is to learn whether the edge design of a finishing orthodontic clear aligner at the gumline affects the bacteria living in the groove between the tooth and the gum (the gingival sulcus) in patients…
- Conditions
- Periodontal Diseases, Malocclusion, Oral Health
- Trial name
- PATHO-ALIGN (NCT07533058)
- Testing
- CA Pro tri-layer finishing clear aligner (SCHEU-DENTAL GmbH)
- Where
- Romania
- Volunteers
- 36 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Tooth Crowding, Tooth; Lesion, White Spot Lesions
Comparison Of Different Orthodontic Aligner Systems Applied On Single Stage And Three Stage
Applying to the Orthodontics Department of the Faculty of Dentistry of Erciyes University for orthodontic treatment, a periodontally healthy 16-26 year-old periodontally healthy, non-congenital or congenital anomaly in the…
- Trial name
- NCT04678596
- Testing
- EonAligner, Clearfix
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Crowding, Tooth, Tipped Tooth or Teeth
Efficacy and Effectiveness of Two Types of Aligners Based on Stratification by Type of Movement
The purpose of this study is to evaluate the biomechanical behaviour of direct-printed and thermoformed aligners in different tooth movements, creating a biomechanical planning protocol based on a stratification of tooth…
- Conditions
- Crowding, Tooth, Tipped Tooth or Teeth, Rotation of Tooth, Malocclusion, Angle's Class
- Trial name
- NCT06516185
- Testing
- direct-printed aligner, thermoformed aligner
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Universidad Complutense de Madrid
Effect of Platelet Rich Fibrin Versus Low Intensity Pulsed Ultrasound During Clear Aligner Therapy
Impact of Injectable Platelet Rich Fibrin Versus Low-intensity Pulsed Ultrasound on Different Orthodontic Tooth Movements During Clear Aligner Therapy
The aim of this prospective clinical project will be to compare the effect of platelet rich fibrin versus low- intensity pulsed ultrasound on therate of different orthodontic tooth movements during clear aligner therapy.
- Trial name
- NCT06276985
- Testing
- low intensity pulsed ultrasound and iPRF
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Clear Aligner Therapy
Effect of Clear Aligner Wear Protocol on External Root Resorption
The aim of this two-arm randomized clinical trial was to compare the effect of 7-day and 14-day orthodontic clear aligner wear protocols on external apical root resorption (EARR) and pain perception
- Trial name
- NCT07522216
- Testing
- Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Malocclusion, Class I/II, Crowding, Tooth
Treatment Outcome of Clear Aligner and Traditional Fixed Appliances in Four Premolar Extraction Cases
Patients with severe crowding requiring the extraction of four premolars will be enrolled in this study. The degree of apical root resorption associated with using the clear aligner technique compared with vestibular fixed…
- Trial name
- NCT07236775
- Testing
- Clear Aligners, Traditional fixed appliances
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Masseter Muscle Activity, Anterior Temporalis Muscle Activity
Orthodontic Clear Aligners Vs Conventional Fixed Appliance's Impact on Muscular Activities Among Adults Using SEMG (Surface Electromyography)
This clinical trial goal is to evaluate the difference in masticatory activities in adult patients treated with clear aligners compared to conventional fixed appliances treatment.
- Trial name
- NCT06699290
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Riyadh Elm University
Malocclusion
Effect of VPro5 Therapy on Clear Aligner Therapy
The investigators hypothesize that brief, daily application of HFA will increase the efficiency of clear aligner treatment by altering PDL metabolism without increasing pain or discomfort.
- Trial name
- NCT03240770
- Testing
- VPro5 device, Deviation from Standard Tray Wear Time (14 Days)
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mani Alikhani
White Spot Lesion
The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study
aim of study: is to compare the effect of the fluoride varnish application on the prevention of white spot lesions (WSLs) during clear aligner therapy Design Details: Each participant will have one side of the mouth assigned to…
- Trial name
- NCT07319884
- Testing
- White spot lesion with fluoride varnish application, White spot lesion without fluoride varnish application
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Patient Comfort, Malocclusion
Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study
The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives…
- Conditions
- Patient Comfort, Malocclusion, Oral Health
- Trial name
- COMFORT-ALIGN (NCT07660809)
- Testing
- Supragingival trimming-line design, Juxtagingival festooned trimming-line design
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Rotation of Tooth
A Novel Attachment Design for Tooth Rotation With Clear Aligner Therapy
Clear aligners are thin, transparent plastic trays that straighten teeth gradually and are a popular, more discreet alternative to traditional braces.
- Trial name
- NCT07881146
- Testing
- novel attachment configuration
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Boston University
Angle Class I Maloclussion, Dental Crowding
Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System
This study is a multi-center, prospective, parallel-group randomized controlled trial designed to compare the orthodontic treatment outcomes of a passive self-ligating bracket system (Damon Ultima) versus a clear aligner system.
- Trial name
- NCT07638397
- Testing
- self ligating bracket, Clear aligner
- Where
- Iraq
- Volunteers
- 42 people
- Sponsor
- University of Baghdad
Distalization, Class II Malocclusion
Comparison of Distalization of Maxillary First and Second Molars Between a Miniscrew Implant Supported Device and Clear Aligners.
The goal of this randomized clinical trial is to compare distalization of maxillary first and second molars achieved with a device supported with mini screw implants in the palate (Advanced Molar Distalization Appliance, AMDA®)…
- Conditions
- Distalization, Class II Malocclusion, Aligner Therapy, Distalization by Miniscrews
- Trial name
- NCT07040176
- Testing
- Upper molar distalization
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Malocclusion
A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.
This is a three-armed, multicenter clinical study evaluating the SureSmile clear aligner medical device. The primary objective is to confirm the safety and assess the accuracy of different tooth movements.
- Trial name
- NCT07290790
- Testing
- SureSmile® Clear Aligners
- Where
- 6 sites in United States, Spain and 1 more
- Volunteers
- 90 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Malocclusion
Accuracy of Dental Movements Using Clear Aligners Treatment: a Single-center Prospective Observational Study
The aim of the present prospective observational study is to evaluate the accuracy of dental movements in the three planes of space, assessing the correspondence between the virtual planned movements and the clinical outcomes…
- Trial name
- NCT06561945
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele