Clinical trials: All Orthopedic Disorders
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Osteoarthritis, Knee
All-Polyethylene Tibias in TKA: PS vs CS Implants
This is a randomized control trial where patients will be randomized to receive one of two types of total knee arthroplasty (TKA) all-polyethylene (AP) tibial components: cruciate retaining (CR) or posterior stabilized (PS).
- Trial name
- NCT03569670
- Testing
- Posterior stabilized all-polyethylene tibial component, Cruciate retaining all-polyethylene tibial component
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Edentulous Jaw
The Effect of Implant-supported Prosthesis on Acoustic Voice Quality
The primary aim of this study was to compare the acoustic sound quality of edentulous patients rehabilitated with two-implant overdentures or the all-on-4 concept.
- Trial name
- NCT05692609
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Knee Osteoarthritis
Evaluation of a New Bi-Condylar Total Knee Prosthesis (TKP) With All-Ceramic Friction (The Forgotten Knee)
The results of TKP (Total Knee Prosthesis) are satisfactory but do not reach those of THP (Total Hip Prosthesis) in terms of indolence and function.
- Trial name
- ForgottenKne (NCT06592248)
- Testing
- Coc Knee
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lymphoblastic Leukemia, Bone Density Increased
Effects of Exercises on Total Body Health in Children With Acute Lymphoblastic Leukemia
In recent years, the survival of patients has increased with the success of leukemia treatment in children. However, according to the treatment modalities applied, complications such as changes in body composition such as…
- Trial name
- NCT04015882
- Testing
- Exercise therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Prevent Osteoporosis and Osteoporotic Fractures, Improve Quality of Life
BREAST CANCER AND EXERCISE
A Finnish Breast Cancer Group Study (BREX 01-2004). A multicenter phase III open randomised trial of the efficacy of exercise in the prevention of long-term adverse effects of adjuvant treatments and breast cancer recurrences in…
- Conditions
- Prevent Osteoporosis and Osteoporotic Fractures, Improve Quality of Life, Improve Weight Control, and Muscular and Cardiovascular Fitness, Help the Patients to Return to Working Life
- Trial name
- BREX (NCT00639210)
- Testing
- supervised training
- Where
- Finland
- Volunteers
- 573 people
- Sponsor
- Finnish Breast Cancer Group
Osteoarthritis
All-poly Versus Metal-backed
The primary objective is the assessment of prosthetic migration results after two years of the Triathlon PS Knee System with all-polyethylene tibial components compared to the Triathlon PS Knee System with metal-backed modular…
- Trial name
- NCT04358601
- Testing
- Triathlon PS Knee System with all-polyethylene tibial components, Triathlon PS Knee System with metal-backed modular components
- Volunteers
- 60 people
- Sponsor
- Region Skane
Sjogren's Syndrome, Pediatric ALL
Belimumab After Rituximab in Resistant Primary Juvenile SS
The goal of this clinical trial is to explore the effectiveness of sequential use of rituximab and belimumab in the treatment of resistant primary juvenile Sjogren's syndrome.
- Trial name
- BRRPJS (NCT06410833)
- Testing
- Rituximab, Belimumab
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking Union Medical College Hospital
Osteoarthritis, Knee
All Polyethylene Versus Metal Backed Tibial Components in Knee Replacement
Total knee arthroplasty (TKA) is one of the most commonly performed orthopaedic procedures. Approximately 84,000 knee replacement procedures were recorded in the UK in 2012.
- Trial name
- NCT02482493
- Testing
- Sigma PFC
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
Bone Loss, Peri-Implantitis
(PEKK) Framework for Mandibular Implant-supported Complete Fixed Prostheses
This clinical study aims to evaluate the effect of using PEKK (Pekkton) framework in mandibular implant-supported complete fixed dental prostheses with All-on-four treatment concept on peri-implant tissues health
- Trial name
- NCT06164990
- Testing
- PEKK framework
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Fatma mahanna
Duchenne Muscular Dystrophy
Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study
This is an open label, long-term safety, tolerability, and efficacy study of GIVINOSTAT in all DMD (Duchenne's muscular dystrophy) patients who have been previously treated in one of the GIVINOSTAT studies.
- Trial name
- NCT03373968
- Testing
- Givinostat
- Where
- 39 sites in United States, Belgium and 9 more
- Volunteers
- 206 people
- Sponsor
- Italfarmaco
Leukemia, Lymphoblastic, Acute, Osteoporosis
A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
Research studies have shown that children who are long-term survivors of childhood leukemia may be at greater risk for early bone loss called osteoporosis.
- Trial name
- NCT00186901
- Testing
- Calcium carbonate (Tums), vitamin D
- Where
- 3 sites in United States
- Volunteers
- 429 people
- Sponsor
- St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia, Nephrotic Syndrome
Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study
To determine the magnitude and rate of bone mass deficits following initiation of glucocorticoid therapy for the treatment of pediatric leukemia, rheumatic conditions and nephrotic syndrome, we propose a 6 year, prospective study…
- Conditions
- Acute Lymphoblastic Leukemia, Nephrotic Syndrome, Rheumatism
- Trial name
- STOPP-CIS (NCT01663129)
- Where
- 12 sites in Canada
- Volunteers
- 406 people
- Sponsor
- Children's Hospital of Eastern Ontario
Pediatric ALL, Nurse's Role
Applying Pediatric Nursing Excellence Model to Nurses in Orthopedic Surgery Care of Children
Problem description: Orthopedic surgeries are common in pediatric orthopedics, treating various conditions resulting from developmental, genetic, neoplastic, nutritional, infection, neurological, or physical injuries.
- Conditions
- Pediatric ALL, Nurse's Role, Surgery
- Trial name
- NCT06624007
- Testing
- pediatric Nursing Excellence (PNE) model
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Jouf University
Prosthodontics, Implants, Dental
Effect of PEEK and Titanium Framework Reinforcement on Marginal Bone Loss Around Implants Supporting a Fixed All-on-four Prosthesis in Completely Edentulous Mandibles
A fixed all-on-four prosthesis will be constructed for the lower arch for each patient and the marginal bone loss will be evaluated at baseline, 3,6,9 and 12 months.
- Conditions
- Prosthodontics, Implants, Dental, Prosthesis, Bone Loss, Alveolar
- Trial name
- NCT07475507
- Testing
- Titanium framework reinforced all on four prosthesis, PEEK framework reinforced all on four prosthesis
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis (OA)
Future Osteoarthritis Treatment - Free Open Online Course for All
The basic treatment for osteoarthritis is education and information, often provided as so-called osteoarthritis schools. These can be provided either physically at the health center or digitally.
- Trial name
- FOOTSTEP (NCT07122154)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Eva Ekvall-Hansson
Orthopedic Disorder
Improve the Quality of Care in Patients With Orthopaedic Disorders
The main objective of the investigators is to improve the quality of care in patients with orthopedic disorders followed in St Luc hospital (Brussels Belgium).
- Trial name
- QualOrtho (NCT02355301)
- Testing
- orthopedic
- Where
- Belgium
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypertension, Osteonecrosis
Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma
This is a randomized unblinded Phase II clinical trial evaluating the impact of intensive antihypertensive control (targeted to the 50-75th percentile for age, sex, and height) compared to conventional antihypertensive control…
- Conditions
- Hypertension, Osteonecrosis, Osteonecrosis Due to Drug
- Trial name
- NCT04401267
- Testing
- Intensive Antihypertensive Therapy, Conventional Antihypertensive Therapy, Symptom Survey
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- St. Jude Children's Research Hospital
Developmental Dysplasia of the Hip
Do All Patients With Congenital Hip Dysplasia Corrected Operatively Need Physiotherapy
Developmental Dysplasia of the Hip (DDH) is a common condition among young children that could range in severity. in most sever cases, surgical intervention is the best choice to correct the hip abnormality with the aim of…
- Trial name
- NCT05238935
- Testing
- prescribed physiotherapy course
- Where
- Kuwait
- Volunteers
- 50 people
- Sponsor
- Ministry of Health, Kuwait
Bone Cancer, Bone Tumor
A Dose Finding Study to Treat Bone Tumor(s)
To determine the Maximum Tolerated Dose (MTD) of CycloSam®, Samarium-153-DOTMP (Sm-153-DOTMP), a radiopharmaceutical that delivers radiation to the bone when injected, given as a tandemly administered pair of doses to subjects…
- Conditions
- Bone Cancer, Bone Tumor, Solid Tumor, Metastatic Cancer to the Bone
- Trial name
- NCT06008483
- Testing
- 153-Sm-DOTMP (Samarium-153-DOTMP)
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- QSAM Therapeutics, Inc.