Clinical trials: Allergic Disease
IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy
A Phase 1 Study of Cizutamig in IgE Mediated Diseases
The purpose of this study is to evaluate the pharmacodynamics, safety, tolerability, pharmacokinetics, and immunogenicity of cizutamig in IgE Mediated Diseases.
- Conditions
- IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy, IgE-Mediated Cow Milk Allergy
- Trial name
- NCT07408869
- Testing
- Cizutamig
- Where
- Australia
- Sponsor
- Candid Therapeutics
Allergic Rhinitis, Allergic Rhinoconjunctivitis
SUBLIVAC FIX Phleum Pratense DT/DRF
The aim of the study is to determine the optimal effective dose of SUBLIVAC FIX Phleum pratense based on reduction of upper airways reactivity after 5 months of treatment with different dosages of SUBLIVAC FIX Phleum pratense…
- Trial name
- NCT01682070
- Testing
- SUBLIVAC FIX phleum prat.
- Where
- 23 sites in Germany, Poland
- Volunteers
- 266 people
- Sponsor
- HAL Allergy
Perennial Allergic Rhinitis, Allergic Rhinitis
Safety of Ciclesonide Nasal Spray Administered With Inhaled Fluticasone Dipropionate/Salmeterol in Adults With Perennial Allergic Rhinitis (BY9010/M1-409)
The purpose of this study is to evaluate the safety and tolerability of combined ciclesonide nasal spray administered along with a fixed combination of inhaled fluticasone dipropionate/salmeterol.
- Conditions
- Perennial Allergic Rhinitis, Allergic Rhinitis, Hay Fever
- Trial name
- NCT00163488
- Testing
- Ciclesonide
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- AstraZeneca
Rhinitis, Allergic, Seasonal, Conjunctivitis, Allergic
Immunotherapy With Depigmented and Polymerized Allergen Extract of Phleum Pratense
The objective of this trial is to evaluate the clinical effectiveness of the administration of a depigmented and polymerized allergen extract of Phleum pratense in the rhinoconjunctivitis and/or asthma of slight or moderate…
- Conditions
- Rhinitis, Allergic, Seasonal, Conjunctivitis, Allergic, Asthma
- Trial name
- NCT00501527
- Testing
- Immunotherapy with modified extract of P. pratense pollen
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Laboratorios Leti, S.L.
Type I Hypersensitivity
Induction of Immunogenicity With Different Doses of Grass MATA in Subjects Allergic to Grass and Rye Pollen
Grass MATA (modified pollen allergen tyrosine adsorbate) has been developed to provide pre-seasonal specific immunotherapy for patients with hypersensitivity to grass and rye pollen.
- Trial name
- NCT00104377
- Testing
- Grass MATA MPL
- Where
- 11 sites in United States
- Volunteers
- 70 people
- Sponsor
- Allergy Therapeutics
Anaphylaxis
Bioavailability of Nasal Epinephrine
A Study to Compare the Bioavailability of Epinephrine following a Single Nasal Dose of FMXIN002 Microspheres Powder with Epinephrine 0.3 mg Intramuscular Injection in Adult Subjects with Seasonal Allergic Rhinitis with and…
- Trial name
- NCT04696822
- Testing
- Epinephrine Nasal Product, 1.6 mg, Epinephrine nasal product, 1.6 mg + allergen, Epinephrine Injection 0.3 mg
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Allergic Rhinitis
Application of Ectoin Allergy Nasal Spray in Comparison to Beclomethasone Nasal Spray
This is a comparative, open label, parallel group, non interventional study to further demonstrate the effectiveness and tolerability of Ectoin® Allergy Nasal Spray.
- Trial name
- NCT02133053
- Testing
- Medical Device, drug-like, Beclomethasone
- Volunteers
- 50 people
- Sponsor
- Bitop AG
Allergic Asthma, Atopic Dermatitis
A Phase 1, Randomized, Placebo-controlled, Dose-escalation Safety Study of MEDI4212 in Subjects With IgE >= 30 IU/mL
Phase 1 study to evaluate the safety of MEDI4212.
- Conditions
- Allergic Asthma, Atopic Dermatitis, Allergic Rhinitis, Healthy Volunteers
- Trial name
- NCT01544348
- Testing
- Omalizumab, MEDI4212 5 mg Subcutaneous, MEDI4212 15 mg Subcutaneous
- Where
- 7 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Asthma, Allergy
Glasgow Asthma and Allergy Study
In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma".
- Trial name
- GLAAS (NCT01618318)
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- National Services for Health Improvement Ltd
Allergic Rhinitis Due to House Dust Mite
Efficacy and Safety of 100IR, 300IR, 500IR Sublingual House Dust Mite Tablets in Allergic Rhinitis Environment Exposure Chamber Model
The purpose of this study is to assess the effect of 3 doses of sublingual house dust mite (HDM) tablets versus placebo in the change from baseline of rhinitis total symptom score during the allergen chamber challenge before and…
- Trial name
- NCT01527188
- Testing
- 100 IR house dust mites allergen extract tablet, 300 IR house dust mites allergen extract tablet, 500 IR house dust mites allergen extract tablet
- Where
- Canada
- Volunteers
- 355 people
- Sponsor
- Stallergenes Greer
Allergic Rhinitis
Efficacy and Safety of MAZ-101 in the Treatment of Persistent Allergic Rhinitis (PER)
The purpose of this study is to evaluate the efficacy and safety of MAZ-101 in the treatment of moderate-severe persistent allergic rhinitis.
- Trial name
- NCT05684380
- Testing
- MAZ-101association, DYMISTA®
- Volunteers
- 514 people
- Sponsor
- EMS
Rhinitis, Allergic, Seasonal, Seasonal Allergic Rhinitis
Prospective Observational Study of Concomitant Allergic Rhinitis Treatment Patterns Among Patients Starting on Fluticasone Furoate Nasal Spray in a Retail Pharmacy Setting
This study is a prospective observational cohort study with 3-month follow-up among a cohort of intranasal steroid (INS) -experienced patients newly starting fluticasone furorate nasal spray (FFNS).
- Trial name
- NCT01337323
- Testing
- Fluticasone furoate nasal spray
- Volunteers
- 3 people
- Sponsor
- GlaxoSmithKline
Allergy
Observational Study of Oralair® in Children 5-9 Years With Grass-pollen-induced Allergic Rhinitis With/Without Conjunctivitis
Safety and tolerability of ORALAIR in children 5 to 9 years of age during the first 30 days of treatment.
- Trial name
- NCT02295969
- Testing
- Oralair
- Where
- Germany
- Volunteers
- 307 people
- Sponsor
- Stallergenes Greer
Allergic Conjunctivitis
An Open-Label, Long-Term Study With AL-4943A Ophthalmic Solution, 0.2% in Patients With Allergic Conjunctivitis
The objective of this study is to assess safety and efficacy of long-term use of AL-4943A (Olopatadine Hydrochloride Ophthalmic Solution, 0.2%) in patients with allergic conjunctivitis.
- Trial name
- NCT01037179
- Testing
- Olopatadine Hydrochloride Ophthalmic Solution, 0.2%
- Where
- Japan
- Volunteers
- 110 people
- Sponsor
- Alcon Research
Allergic Rhinitis Due to Allergens
Dymista in Chinese Adolescents
The purpose of this study is to determine if the investigational drug product ("study drug"), Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray is safe and effective in the treatment of allergic rhinitis…
- Trial name
- NCT07597473
- Testing
- Treatment with 137 µg azelastine hydrochloride and 50 μg of fluticasone propionate
- Where
- 14 sites in China
- Volunteers
- 100 people
- Sponsor
- Viatris Inc.
Allergic Rhinitis Due to Weed Pollen, Allergic Rhinitis
Trial of INI-2004 in Healthy Volunteers and Participants With Allergic Rhinitis.
This is a Phase I/Ib, randomised, double-blind, placebo-controlled study of INI-2004, administered as single or multiple doses. This study will be conducted in two parts: Phase I single ascending dose (SAD) and Phase Ib multiple…
- Trial name
- NCT06038279
- Testing
- INI-2004
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Inimmune Corporation
Rhinitis, Allergic, Perennial
Study Of Perennial Allergic Rhinitis In Pediatrics
To verify of cetirizine dry syrup to ketotifen dry syrup in the change of total nasal symptom score (TNSS) over the total treatment period from the score of the baseline assessment period
- Trial name
- NCT00253058
- Testing
- Cetirizine Dry Syrup
- Volunteers
- 286 people
- Sponsor
- GlaxoSmithKline
Peanut Allergy
Real-World AR101 Market-Supporting Experience Study in Peanut-Allergic Children (RAMSES)
This is a multicenter, randomized, double-blind, placebo-controlled safety study of AR101 using the characterized oral desensitization immunotherapy (CODIT™) regimen in peanut-allergic children.
- Trial name
- RAMSES (NCT03126227)
- Testing
- AR101
- Where
- 67 sites in United States, Canada
- Volunteers
- 506 people
- Sponsor
- Aimmune Therapeutics, Inc.
Rhinitis, Allergic, Seasonal
A Study Comparing the Clinical Equivalence of Two Mometasone Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis
This study compared the efficacy and safety of a generic mometasone nasal spray to the reference listed drug in the treatment of seasonal allergic rhinitis.
- Trial name
- NCT01038427
- Testing
- Mometasone furoate 50 mcg/actuation nasal spray (Lek Pharmaceuticals), Mometasone furoate (Nasonex®) 50 mcg/actuation nasal spray
- Where
- 8 sites in United States
- Volunteers
- 795 people
- Sponsor
- Sandoz
Allergy
Wheal and Flare Reaction During 24 Hours in Allergic Volunteers.
Compare the activity of 5 mg levocetirizine and 5 mg desloratadine on allergen-induced wheal and flare reaction.
- Trial name
- NCT00521170
- Testing
- Levocetirizine
- Where
- 2 sites in France
- Sponsor
- UCB Pharma
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