Clinical trials: Allergic Disease
Allergic Asthma, Allergic Rhinitis
The Effect of Allergen Immunotherapy on Exhaled Nitric Oxide in Adult Patients With Asthma and Allergic Rhinitis
This study will evaluate whether exhaled nitric oxide levels are affected by allergen immunotherapy ("allergy shots"). The investigators' hypothesis is that successful allergen immunotherapy may be accompanied by decreased…
- Trial name
- NCT01318954
- Testing
- Allergen immunotherapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Seasonal Allergic Rhinitis
Compare Captisol-Enabled (CE) Budesonide + Azelastine Nasal Solution and Rhinocort Aqua + Astelin in an Environmental Exposure Chamber (EEC) Study of Allergic Rhinitis
The primary objective of this study was to compare Placebo to Captisol-Enabled Budesonide + Azelastine in a single spray and two separate sprays (Budesonide + Azelastine) in patients with Seasonal Allergic Rhinitis exposed to…
- Trial name
- NCT00940953
- Testing
- Budesonide + Azelastine
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Ligand Pharmaceuticals
Eczema, Asthma
Influence of Probiotics on Atopy, Immunological Responses and Gut Microflora - Follow-up to 5 Years
The investigators had conducted a double-blind, randomized placebo-controlled clinical trial studying the effects of 6 months probiotics supplementation from birth on allergic disease and sensitization up to 2 years of age.
- Conditions
- Eczema, Asthma, Allergic Rhinitis
- Trial name
- NCT00365469
- Testing
- Probiotic
- Where
- Singapore
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Allergic Rhinitis
HDM and Silver Birch NAC Standardisation
This study aims to establish dose-responses to nasal allergen challenge using silver birch pollen and house dust mite allergen extracts in participants with allergic rhinitis, sensitised to either or both of these allergens.
- Trial name
- NCT05378594
- Testing
- Nasal allergen challenge
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Rhinitis, Allergic, Seasonal
A Dose-finding Study of ASP4070
The objective of this study was to evaluate the efficacy, safety, and dose-response of ASP4070 vaccinated in patients with cedar pollinosis.
- Trial name
- NCT03101267
- Testing
- ASP4070
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Astellas Pharma Inc
Seasonal Allergic Rhinitis
Allergen Biocube Study Evaluating Efficacy and Safety of Nasapaque Nasal Solution in Adult Subjects With Allergic Rhinitis
Single-center, double-masked, randomized, placebo-controlled, parallel-group, efficacy and safety study using the Allergen BioCube (ABC).
- Trial name
- NCT02377895
- Testing
- Nasapaque Nasal Solution
- Volunteers
- 73 people
- Sponsor
- 3E Therapeutics Corporation
Perennial Allergic Rhinitis
Cosalin® Monotherapy Versus Cosalin® and Xarlin® Combination Therapy
Title of Study: A randomized, parallel, double-blind, multi-center, comparative study to evaluate the efficacy and safety of Cosalin monotherapy versus Cosalin and Xarlin combination therapy in patients with allergic rhinitis…
- Trial name
- NCT01062139
- Testing
- Xarlin (Levocetirizine), Cosalin (Petasites hybridus CO2 extract)
- Volunteers
- 100 people
- Sponsor
- HK inno.N Corporation
Rhinitis, Allergic, Seasonal
Compare the Efficacy of Levocetirizine and Montelukast to Placebo in Reducing Seasonal Allergic Rhinitis (SAR) Symptoms in Ragweed Sensitive Subjects
To compare the clinical efficacy of levocetirizine 5 mg and montelukast 10 mg on symptoms of seasonal allergic rhinitis occurring in subjects exposed to ragweed pollen in an environmental exposure unit.
- Trial name
- NCT00295022
- Testing
- Montelukast, Levocetirizine
- Where
- Canada
- Volunteers
- 418 people
- Sponsor
- UCB S.A. - Pharma Sector
Allergic Asthma
Extracorporeal SPecific IgE Removal From the Plasma of Allergic Asthma Patients (ESPIRA-study)
In this study patients suffering from Immunoglobulin E (IgE) mediated asthma are treated with a method, called immune apheresis, that removes IgE from blood.
- Trial name
- ESPIRA (NCT02096237)
- Testing
- IgE adsorber
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Contact Allergic Dermatitis, Adverse Skin Reaction
Aquacel Hypersensitivity Dressing in TJAs
The aim of this multi-surgeon, single institution study is to prospectively evaluate the incidence of allergic contact dermatitis (ACD) following application of AQUACEL Ag, a silver-containing hydrofiber dressing, in total hip…
- Trial name
- NCT06011629
- Testing
- Aquacel dressing
- Where
- United States
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Seasonal Allergic Rhinitis
Clinical Equivalence Study of Mometasone Nasal Spray, 50 Mcg/Actuation
The objective of this study is to evaluate the clinical equivalence of the test formulation of mometasone furoate anhydrous 50 mcg/actuation nasal spray (manufactured by Teva Pharmaceutical Industries, Ltd.
- Trial name
- NCT01523236
- Testing
- Mometasone furoate, Nasonex®
- Volunteers
- 800 people
- Sponsor
- Teva Pharmaceuticals USA
Allergic Conjunctivitis
The INVIGORATE Trial: A Clinical Trial to Assess the Efficacy and Safety of Subjects With Seasonal Allergic Conjunctivitis.
The INVIGORATE Trial: A Randomized, Double-masked, Crossover Design, Phase 3 Clinical Trial to Assess the Efficacy and Safety of Subjects With Seasonal Allergic Conjunctivitis.
- Trial name
- NCT04207736
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Ophthalmic Solution
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Rhinitis, Allergic, Asthma, Allergic
Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children
Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of…
- Conditions
- Rhinitis, Allergic, Asthma, Allergic, Conjunctivitis, Allergic, Atopic Dermatitis
- Trial name
- NCT06063044
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Food Allergy
Study Using Xolair in Rush Multi Oral Immunotherapy in Multi Food Allergic Patients
This is a pilot randomized, double-blind, placebo controlled study which will be conducted at a single center. All participants will receive oral immunotherapy for their specific food allergies (limited to 5 of those food…
- Trial name
- MAP-X (NCT02643862)
- Testing
- Xolair
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
Allergic Rhinitis
Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study
About 45 million people in Europe have allergic rhinitis (hay fever) - inflammation of the nasal passages causing sneezing, runny nose, nasal congestion, itching and tearing of the eyes.
- Trial name
- Pollen+ (NCT02005627)
- Testing
- Grazax
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Allergic Rhinitis
Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age
To determine the Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age.
- Trial name
- NCT04957927
- Testing
- Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Usama Azhar
Asthma, Atopy
Imaging Study of the Lungs During an Allergic Asthma Attack
Asthma is a disease of rapidly increasing incidence that already affects more than 17 million people in the United States alone.
- Trial name
- NCT01547286
- Testing
- Standardized Cat Allergen Extract and Standardized Dust Mite Allergen, Computed Tomography imaging, functional Positron Emission Tomography imaging, Nebulized methacholine inhalation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Seasonal Allergic Rhinitis
Allergen Challenge Trial of IRL201104 in Seasonal Allergic Rhinitis
The purpose of this allergen challenge study is to assess the efficacy of IRL201104 compared with placebo in adult participants with seasonal allergic rhinitis.
- Trial name
- NCT05098522
- Testing
- IRL201104
- Where
- 2 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- Revolo Biotherapeutics
Rhinitis, Allergic, Seasonal
Study of a Topical Nasal Spray to Ease the Symptoms of Hayfever
The purpose of this study is to see if a new nasal spray can reduce the signs and symptoms of allergic rhinitis (hayfever). Subjects' participation in the study will last approximately 4 to 6 weeks, and each of three study visits…
- Trial name
- NCT01500629
- Testing
- C-1266-7
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Allergic Asthma, Airway Remodelling
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma
Asthma is a major noncommunicable chronic inflammatory disorder which is characterized by airway inflammation and related to pathological modifications of the bronchial wall structure so called airway remodeling.
- Conditions
- Allergic Asthma, Airway Remodelling, Extracellular Matrix Alteration
- Trial name
- ECMA (NCT03388359)
- Testing
- Bronchial challenge with allergen, Co-culture formation, Inhibition of Wnt and Smad signaling pathways
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
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