Clinical trials: Allergic Disease
Allergy
Effects of the Direct Interaction Between Streptococcus Salivarius 24SMBc and Streptococcus Oralis 89a and the Respiratory Epithelium in Children
Allergic rhinoconjunctivitis is a pathology of the nasal and conjunctival mucosa induced by Immunoglobulin E (IgE) mediated inflammation following allergic exposure.
- Trial name
- NCT03449836
- Testing
- Streptococcus salivarius 24SMBc + Strept. oralis 89a, fluticasone + mometasone
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning
Multi-Omics Inflammatory Phenotype for ABPA Recurrence Risk Prediction
To develop and externally validate a machine learning model for predicting the 1-year risk of relapse in patients with stable ABPA, and to further evaluate its value in risk stratification and clinical decision-making.
- Conditions
- Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning, Multi-omics, Multicenter Study
- Trial name
- NCT07611838
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Seasonal Allergic Rhinitis
Phase II/III Seamless Clinical Study of MG-K10 Humanized Monoclonal Antibody Injection in Treatment of Seasonal Allergic Rhinitis
A multicenter, randomized, double-blind, placebo-controlled Phase II/III seamless clinical study evaluating the efficacy, safety, pharmacokinetic (PK) profile, pharmacodynamic (PD) profile, and immunogenicity of MG-K10 humanized…
- Trial name
- NCT06846385
- Testing
- MG-K10 Humanized Monoclonal Antibody Injection
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Mabgeek Biotech.Co.Ltd
Severe Asthma
3TR Asthma Biologics Cohort (ABC) Study
The 3TR-ABC study is a multicentre observational prospective cohort study platform that follows patients with severe asthma from the start of biological therapy and three years onwards.
- Trial name
- 3TR-ABC (NCT06126692)
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Peanut Allergic Subjects
Peanut Oral Immunotherapy in Children With Peanut Allergy (Peanut Flour)
Many children who are allergic to peanuts do not outgrow their allergy and have very severe allergic reactions called anaphylaxis.
- Trial name
- PeanutFlour (NCT02203799)
- Testing
- Peanut Oral Immunotherapy (POIT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Allergic Rhinitis
House Dust Mite Allergen Reduction in Bedding: Purotex Impregnated Covers of Bekaert Textiles
Product information: Purotex is a textile treatment that uses five 100% natural bacteria or probiotics, selected for their ability to clean up house dust mite allergen along with other allergen types.
- Trial name
- Purotex covers (NCT01997606)
- Testing
- use of Purotex treated bedding covers
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Asthma, Allergic
Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze.
- Trial name
- NCT05740748
- Testing
- Tezepelumab
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Asthma
The Effect of Xolair (Omalizumab) on Allergy Blood Cells
We are studying Xolair (omalizumab) to see it's effect on allergic blood cells. The blood tests will be done in a test tube to see if they react differently before and after treatment.
- Trial name
- NCT00657891
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Creighton University
Atopic Dermatitis, Food Allergy
Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project
This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for…
- Conditions
- Atopic Dermatitis, Food Allergy, Healthy
- Trial name
- NCT06300697
- Testing
- Data and biospecimen collection, Skin biopsies, Oral Food Challenge (OFC) procedures
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Eczema, Asthma
Study of Stool Microbiota in Two Diverse Cohorts of Asian and Its Influence on Allergy Development
This study aims to document prospectively the incidence of allergies of eczema, asthma and allergic rhinitis in 2 diverse cohorts (Singaporean and Indonesian) with contrasting lifestyles and socioeconomic development.
- Conditions
- Eczema, Asthma, Allergic Rhinitis
- Trial name
- NCT00713089
- Where
- 2 sites in Indonesia, Singapore
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Perennial Allergic Rhinitis, Rhinitis, Allergic
Efficacy and Safety of AM-301 on Allergic Symptoms of Perennial Allergic Rhinitis Sufferers
Alleviation of allergic symptoms induced by house dust mites when using the medical device AM-301. This clinical investigation explored the efficacy and safety of AM-301 when used to reduce symptoms of house dust mite sufferers.
- Trial name
- NCT05122143
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Altamira Medica Ltd.
Rhinitis, Allergic, Perennial
Study FFR116364, a Placebo-controlled Study of GW685698X in Paediatric Subjects With Perennial Allergic Rhinitis
Efficacy and safety of GW685698X (55 µg/day, q.d.) nasal spray over a period of 2 weeks in Japanese paediatric subjects ages 6 to < 15 years with perennial allergic rhinitis will be evaluated compared with placebo.
- Trial name
- NCT01630135
- Testing
- Fluticasone furoate
- Where
- 22 sites in Japan
- Volunteers
- 261 people
- Sponsor
- GlaxoSmithKline
Anaphylactic Reaction, Anaphylaxis
Steroid Use in Treatment of Allergic Reactions to Food
In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary.
- Conditions
- Anaphylactic Reaction, Anaphylaxis, Allergy in Children, IgE Mediated Food Allergy
- Trial name
- SAFARI (NCT07341776)
- Testing
- Antihistamines, Systemic corticosteroids, Adrenaline (rescue medication)
- Where
- 2 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Johannes Trueck
Asthma, Allergic Rhinitis
Assessment of Oxidative Stress Markers in the Upper and Lower Airways of Atopic Children Treated With Nebulized Beclomethasone
Although it is well known that the presence of uncontrolled inflammation in upper airways may compromise the control of asthma and may favor the progression of asthma toward more severe grades of disease, few studies addressed…
- Trial name
- NCT01113489
- Testing
- beclomethasone dipropionate
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
ALLERGIC RHINITIS
Repeated Nasal Challenge in Skin Prick-puncture Negative and Intradermal Positive Dust Mite Allergic Rhinitis Patients
Subjects who have a clinical history of perennial rhinitis symptoms associated with dust exposure or not associated with other perennial allergens, will have a positive challenge with Dermatophagoides pteronyssinus.
- Trial name
- DUSTMITE (NCT01179282)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Allergic Rhinitis, Allergic Rhinoconjunctivitis
Efficacy and Safety of Norketotifen in Adults With Allergic Rhinitis
This is a Phase 2a study to evaluate the efficacy and safety of Norketotifen (NKT) in subjects with allergic rhinitis.
- Trial name
- NCT03887026
- Testing
- Norketotifen
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Emergo Therapeutics, Inc.
Rhinitis, Allergic, Perennial, Hay Fever
To Assess the Safety of Ciclesonide, Applied as a Nasal Spray at Three Dose Levels, in the Treatment of Perennial Allergic Rhinitis in Pediatrics (BY9010/M1-405)
The primary objective of this study is to demonstrate the safety of three dose levels of ciclesonide administered as an intranasal spray for six weeks, 200µg, 100µg or 25µg, once daily, in pediatric patients (ages 2-5 years) with…
- Trial name
- NCT00658918
- Testing
- Ciclesonide nasal
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Asthma
No Resistance After Long Term Treatment SERETIDE
This multi centre, double blind, comparator controlled, parallel group study is to determine whether asthma treatment with high doses of fluticasone propionate (FP) redirects a Th2/ eosinophil response towards a more treatment…
- Trial name
- NCT00456313
- Testing
- FLIXOTIDE and SERETIDE
- Where
- 2 sites in Netherlands
- Sponsor
- GlaxoSmithKline
Allergy
Treatment Modalities in Children and Adolescents Suffering From HDM-induced Allergic Rhinitis and/or Asthma
Two-stage, prospective, observational, real-world study of HDM-SLIT-naïve children (aged 5-11) and adolescents (aged 12-17) consulting allergists or other specialist physicians in France for an HDM-induced allergy.
- Trial name
- PROTECT (NCT04004351)
- Volunteers
- 1,531 people
- Sponsor
- Stallergenes Greer
Allergic Conjunctivitis
A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy
This study is researching 2 experimental drugs, REGN5713 and REGN5715, which are called REGN5713-5715 when mixed together (called "study drug") to reduce eye allergy signs and symptoms due to birch tree pollen allergy.
- Trial name
- NCT06602739
- Testing
- REGN5713, REGN5715
- Where
- 3 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Regeneron Pharmaceuticals
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