Clinical trials: Allergic Diseases
Allergic Asthma
Efficacy of Omalizumab in Adults (18-60 Years of Age) With Moderate-Severe, Persistent Allergic Asthma, Despite Receiving Inhaled Corticosteroids and Long Acting Beta-agonists
This study aims to investigate the effect of omalizumab on the number of tissue eosinophils and other markers of airway inflammation and remodeling, including thickness of the lamina reticularis, in moderate to severe asthmatics…
- Trial name
- eXplore (NCT00670930)
- Testing
- omalizumab at a dose of 0.016mg/kg/IU/mL
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Peanut Allergy
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of IGNX001
The goal of this randomized, double-blind, placebo-controlled, single ascending dose clinical trial is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of IGNX001 in peanut-allergic adults and older…
- Trial name
- NCT06331728
- Testing
- IGNX001
- Where
- 4 sites in Australia
- Volunteers
- 32 people
- Sponsor
- IgGenix Australia Pty Ltd
Allergic Conjunctivitis
Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge (CAC) Model
The purpose of this study is to evaluate the effectiveness of the modified Conjunctival Allergen Challenge (CAC) and observe how the produced allergic inflammation reacts to treatment with a proven ocular anti-inflammatory…
- Trial name
- NCT01534195
- Testing
- Prednisolone Sodium Phosphate Ophthalmic Solution 1%, Tears Naturale II Ophthalmic Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- ORA, Inc.
Multiple Myeloma
Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injection Site Reactions to Motixafortide in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization, PARADE Trial
This phase IV trial compares the effect of premedication regimens with methylprednisolone versus dexamethasone for the prevention of allergic reaction to motixafortide in patients with multiple myeloma (MM) undergoing stem cell…
- Trial name
- NCT07101445
- Testing
- Acetaminophen, Biospecimen Collection, Dexamethasone
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Emory University
Asthma
To Evaluate the Inflammatory Markers in Adult Patients With Asthma Associated With Allergic Rhinitis Receiving Montelukast Therapy (0476-366)
To evaluate the changes in proinflammatory markers (ltd4 in urine) and eosinophil from peripheral blood after newly initiated montelukast therapy.
- Trial name
- NCT00398151
- Testing
- MK0476, montelukast sodium / Duration of Treatment: 12 Weeks
- Volunteers
- 58 people
- Sponsor
- Organon and Co
Allergic Asthma
Cobra (Severe Asthma)Medical-economic
The severe asthma is a major source of expenses in term of public health, while it concerns no more than 5 % of the asthmatics. The expenses is direct (medicines, hospitalizations, care) but especially indirect (absenteeisms…
- Trial name
- Cobra (NCT01669681)
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Montpellier
Allergic Rhinitis, Asthma (Diagnosis)
Evaluation of ALLERgen Specific Vaccination of DOG Allergic Patients in Swedish Practice
STUDY DESIGN A single-center prospective before-and-after study evaluating the effect of Alutard SQ Dog in 40 men and women with moderate-to-severe dog allergy. Participants will serve as their own controls.
- Trial name
- ALLERDOG (NCT07651891)
- Testing
- ALK Alutard SQ Dog
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Rhinitis, Allergic
MK0476 Study in Adult Patients With Perennial Allergic Rhinitis (0476-397)(COMPLETED)
A clinical study evaluates the efficacy and safety of MK0476 in adult patients with Perennial Allergic rhinitis.
- Trial name
- NCT00771160
- Testing
- montelukast sodium
- Volunteers
- 120 people
- Sponsor
- Organon and Co
Hives
Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline
Investigators will study the effects of topical doxycycline on cutaneous allergic early and late phase responses by determining allergen skin responses in each subject after a single application to allergen induced allergic…
- Trial name
- NCT03968562
- Testing
- 2% Doxycycline Cream in Generic Aquaphor or Generic Aquaphor
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Asthma, House Dust Mite Allergy
Dose Ranging Study of SLIT Tablets of House Dust Mite Allergen Extracts (HDM) in Adults With HDM-associated Allergic Asthma
The purpose of this study is to investigate the efficacy and safety of different doses of sublingual tablets of house dust mite allergen extracts as compared to placebo in adults with house dust mite-associated allergic asthma.
- Trial name
- NCT01930461
- Testing
- SLIT tablets of HDM allergen extracts, 3 different doses (A), SLIT tablets of HDM allergen extracts, 3 different doses (B), SLIT tablets of HDM allergen extracts, 3 different doses (C)
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 386 people
- Sponsor
- Stallergenes Greer
Asthma, Allergic Rhinitis
Influence of Probiotics on Atopy With Focus on Respiratory Allergic Diseases- Follow-up to 7 Years
The investigators had conducted an initial double-blind, placebo-controlled clinical trial (NCT00318695) to study the effects of probiotic supplementation from birth to 6 months of age in the incidence of atopic diseases at 2…
- Trial name
- NCT00826189
- Where
- Singapore
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Allergy Pollen, Allergic Reaction
Juniperus Oxycedrus and Cupressus Arizonica Allergen Extracts Standardisation.
The objective of this study is to determine the biological activity of Juniperus oxycedrus and Cupressus arizonica. allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference…
- Conditions
- Allergy Pollen, Allergic Reaction, Allergic Skin Reaction
- Trial name
- NCT05533385
- Testing
- Allergenic extract
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Inmunotek S.L.
Allergic Rhinitis
AllerPops Reduce Nasal Symptoms in Adult Volunteers With Allergic Rhinitis
The goal of this clinical trial is to test AllerPops' effectiveness in people who suffer from allergic rhinitis. The main question[s]it aims to answer are: 1.
- Trial name
- NCT05956691
- Testing
- AllerPops
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- AllerPops Corp
Asthma
No Resistance After Long Term Treatment SERETIDE
This multi centre, double blind, comparator controlled, parallel group study is to determine whether asthma treatment with high doses of fluticasone propionate (FP) redirects a Th2/ eosinophil response towards a more treatment…
- Trial name
- NCT00456313
- Testing
- FLIXOTIDE and SERETIDE
- Where
- 2 sites in Netherlands
- Sponsor
- GlaxoSmithKline
Seasonal Allergic Rhinitis (SAR)
Study of Stapokibart Injection in Adolescent Subjects With Seasonal Allergic Rhinitis (SAR)
This study is a multicenter, single-arm, open-label, phase II study to evaluate the safety, pharmacokinetics, and immunogenicity of Stapokibart injection in Adolescent Patients with SAR.
- Trial name
- NCT07617324
- Testing
- Stapokibart injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Chengdu Kangnuoxing Biopharma,Inc.
Allergic Bronchopulmonary Aspergillosis, Severe Asthma
Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis
An open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- Allergic Bronchopulmonary Aspergillosis, Severe Asthma, ABPA
- Trial name
- NCT07530770
- Testing
- Fasenra
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Qianfoshan Hospital
Asthma
Total IgE (Immunoglobulin E) and Der p 1 (d1) Specific IgE in Induced Sputum in Patients With Allergic and Non-allergic Asthma
Asthma is a heterogeneous disease, and specifically the phenotype of non-allergic asthma is not yet well defined. Several studies describe this group of patients as having severe asthma, persistent eosinophilia and poor…
- Trial name
- NCT03640936
- Testing
- Induced Sputum
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Seasonal Allergic Rhinitis
The Effect of Nasal Carbon Dioxide (CO2) in the Symptomatic Treatment of Seasonal Allergic Rhinitis
The purpose of this study is to evaluate the effect of four times a day treatment with nasal carbon dioxide in patients with Seasonal Allergic Rhinitis symptoms.
- Trial name
- NCT00917111
- Testing
- Nasal CO2
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Capnia, Inc.
Food Allergy
Molecular Analysis of IgE Antibodies in Walnut Allergic Patients
Accurate diagnosis of food allergy depends on the identification of the causative allergenic molecule(s). The proposed study intends to investigate and compare the pattern of IgE antibody sensitisation in walnut allergic subjects…
- Trial name
- NCT02295267
- Testing
- walnut allergy provocation
- Where
- Switzerland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Rhinitis, Allergic, Perennial
Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis
Ketotifen is an established antihistamine drug, widely used in pediatric clinical practice in Japan. The objective of the study was to compare the efficacy and safety of cetirizine hydrochloride versus ketotifen dry syrup on…
- Trial name
- NCT00639587
- Testing
- Ketotifen, Cetirizine
- Volunteers
- 149 people
- Sponsor
- UCB Pharma