Clinical trials: Allergic Inflammation
Allergic Rhinitis, Allergic Inflammation
Changes in Adaptive Immune Responses and Effector Cell Responses Upon Nasal Allergen Exposure - a Pilot Study
IgE-associated allergy is a hypersensitivity disease affecting more than 25% of the population in industrialised countries. The recognition of allergen by immunoglobulin E (IgE) plays a central role in the cause of allergic…
- Trial name
- NCT03644680
- Testing
- Nasal Provocation with Birch Extract, Nasal Provocation with NaCl 0.9%
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Allergic Rhinitis
Effect of Laser Acupuncture Alone or Combined With Pranayama Exercise on Inflammation in Allergic Rhinitis
Allergic rhinitis (AR) represents one of the most common global health problems with seriously increasing incidence over the last decades.The goal of the treatment of rhinitis is to prevent or reduce the symptoms through…
- Trial name
- NCT05553483
- Testing
- pranayama plus acupoint stimulation by laser, acupoint stimulation by laser
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Allergic Conjunctivitis
Evaluation of Efficacy of Coadministration of FOV1101-00 and Prednisolone Acetate in Patients With Mild Ongoing Ocular Allergic Inflammation
This is a phase 2 study that will consist of 3 visits during a 3 week period conducted at up to 5 sites. The purpose of this study is to determine how effective the combination of Pred Mild® and FOV1101-00 is compared to either…
- Trial name
- NCT00833495
- Testing
- Prednisolone Acetate 0.12% (Pred Mild®), FOV1101-00, Prednisolone Acetate 1% (Pred Forte®)
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Fovea Pharmaceuticals SA
Airways Allergic Inflammation of Asthmatic Children
Beneficial Effects of Lactobacillus Reuteri DSM 17938 Supplementation on Asthmatic Children
Objective The aim of the trial is to evaluate the beneficial effects of the oral administration of the probiotic L. Reuteri (Reuterin®) on the airways allergic inflammation in children with mild to moderate persistent asthma.
- Trial name
- NCT01241084
- Testing
- Antileukotrienes + Lactobacillus reuteri
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Allergic Rhinitis, Allergy
Pollutant Altered Allergic Responses
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens.
- Trial name
- NCT00011440
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Allergic Conjunctivitis
The Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic Conjunctivitis
A double-blind study to evaluate the role of vitamin D in corneal epithelial barrier function, ocular microbiome, ocular inflammation, and visual acuity of children with allergic conjunctivitis.
- Trial name
- NCT05839938
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Asthma
Eosinophilic Airway Inflammation and Mepolizumab
A drug (mepolizumab) that reduces allergic inflammation will affect the function of allergy cells called eosinophils which are produced by the body in response to allergen exposure.
- Trial name
- NCT00802438
- Testing
- mepolizumab
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Wisconsin, Madison
Severe Asthma, Asthma in Children
Severe Eosinophilic Asthma Phenotypes During Childhood Have Various Origins
Study of the clinical evolution at 10 years of children from the SAMP cohort (severe asthma, eosinophilic or not, allergic or not) in order to understand the different possible evolutions of these phenotypes at different ages.
- Trial name
- SAMP 2 (NCT05762627)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, Allergic
Anakinra as a Rescue Treatment for Allergic Inflammation
Participants with mild asthma who are sensitized to either house dust mite or cat hair allergen will undergo nasal instillation of the allergen to elicit nasal allergy symptoms.
- Trial name
- NCT04035109
- Testing
- Anakinra, House dust mite allergen, Cat hair allergen
- Sponsor
- University of North Carolina, Chapel Hill
Bronchial Asthma, Food Allergy
Effects of Montelukast in Asthmatic Children With and Without Food Allergy
To search the effects of montelukast on the airway inflammation including FEV1%, FEV1%/FVC, the provocholine® (methacoline chloride powder for inhalation) challenge tests, the leukotriene levels in the exhaled breath condensate…
- Conditions
- Bronchial Asthma, Food Allergy, Children
- Trial name
- NCT01618929
- Testing
- Montelukast
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Hacettepe University
Asthma, Airway Inflammation
Asthma Study Comparing Anti-Inflammatory Effects of 3 Doses of Mometasone Furoate/Formoterol Fumarate and Medium Dose Mometasone Furoate (Study P05122 AM1)(COMPLETED)
This is a 2-week double-blind, placebo-controlled, parallel group study comparing the anti-inflammatory effects of low, medium, and high dose mometasone furoate/formoterol fumarate (MF/F) metered dose inhaler (MDI) formulation…
- Trial name
- NCT00635882
- Testing
- mometasone furoate/formoterol 100/10 mcg, mometasone furoate/formoterol 200/10 mcg, mometasone furoate/formoterol 400/10 mcg
- Volunteers
- 93 people
- Sponsor
- Organon and Co
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Allergic Rhinitis, Asthma
Effects of Whole Sprouts on Airway Allergic Inflammation
The primary objective of this study is to determine if broccoli sprouts (BS) improves airway inflammatory, oxidative stress (OS), and symptoms among asthmatic adults with aeroallergen sensitization.
- Conditions
- Allergic Rhinitis, Asthma, Allergy
- Trial name
- NCT01522703
- Testing
- Broccoli Sprouts
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Immunotherapy, Seasonal Allergic Rhinitis
Regulatory Lymphocytes in Patients Treated With Specific Immunotherapy
The purpose of this study is to determine whether specific subcutaneous immunotherapy affects fractions of regulatory T lymphocytes and histamine H2 receptor expression and ZAP70 in regulatory T lymphocytes.
- Trial name
- NCT01475188
- Testing
- Allergovit
- Where
- Poland
- Volunteers
- 41 people
- Sponsor
- Ministry of Science and Higher Education, Poland
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Rhinitis, Allergic, Seasonal, Seasonal Allergic Rhinitis
Trial With Allergic Rhinitis Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber
This study is in patients with seasonal allergic rhinitis (SAR) and will compare the effect versus placebo of repeat doses of intranasal GSK256066 using the Vienna Challenge Chamber.
- Trial name
- NCT00430157
- Testing
- GSK256066
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- GlaxoSmithKline
Allergic Asthma
AsthMatic Inflammation and Neurocircuitry Activation (MINA)
The investigators have identified areas of the brain that are activated in response to disease-related emotional information, following whole lung allergen challenge in asthma.
- Trial name
- MINA (NCT02764437)
- Testing
- Whole lung antigen challenge, segmental allergen challenge
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Wisconsin, Madison
Allergic Rhinitis
Effects of Multiple Nasal Exposures to House Dust Mite Allergen on Nasal and Body Inflammation and Airway Sensitivity
This study will evaluate whether multiple nasal antigen challenges with dust mite allergen produces increases in nasal symptoms and local allergic inflammatory cells in the nose and the blood.
- Trial name
- NCT00513487
- Testing
- Dust mite extract, Fluticasone, Methacholine
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Novartis
Allergic Asthma
Efficacy of Omalizumab in Adults (18-60 Years of Age) With Moderate-Severe, Persistent Allergic Asthma, Despite Receiving Inhaled Corticosteroids and Long Acting Beta-agonists
This study aims to investigate the effect of omalizumab on the number of tissue eosinophils and other markers of airway inflammation and remodeling, including thickness of the lamina reticularis, in moderate to severe asthmatics…
- Trial name
- eXplore (NCT00670930)
- Testing
- omalizumab at a dose of 0.016mg/kg/IU/mL
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Hayfever
Lactobacillus Acidophilus L92 on Markers of Allergic Inflammation by Nasal Provocation With Grass Pollen
This is a placebo controlled double-blind single center study initiated and sponsored by CALPIS, Inc., Japan, and CALPIS U.S.A., Inc., Torrance, CA.
- Trial name
- NCT00554736
- Testing
- Lactobacillus acidophilus L-92
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis