Clinical trials: Allergic Inflammation
Infection, Inflammation
Understanding Childhood Infection, Inflammation and Allergy
This proposal represents a unified programme supported by both clinical and academic staff in the Departments of Paediatrics at Imperial College and St Mary's Hospital, Southampton Hospital and John Radcliffe Hospital (Oxford).
- Conditions
- Infection, Inflammation, Allergy, Children
- Trial name
- NCT01022268
- Where
- United Kingdom
- Volunteers
- 902 people
- Sponsor
- Imperial College London
Conjunctivitis, Allergic
OJO-miR: microRNA Expression in Allergic Conjunctivitis.
Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life.
- Trial name
- OJO-miR (NCT07385495)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Dermatophagoides Farinae Allergy, Asthma
Evaluation of a Nasal Allergen Challenge Procedure Using Dust Mite Extract
The purpose of this study is to serve as a pilot safety study for nasal allergen challenges.
- Conditions
- Dermatophagoides Farinae Allergy, Asthma, Healthy
- Trial name
- Dusty (NCT00927329)
- Testing
- dust mite inhalation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hayfever
Lactobacillus Acidophilus L92 on Markers of Allergic Inflammation by Nasal Provocation With Grass Pollen
This is a placebo controlled double-blind single center study initiated and sponsored by CALPIS, Inc., Japan, and CALPIS U.S.A., Inc., Torrance, CA.
- Trial name
- NCT00554736
- Testing
- Lactobacillus acidophilus L-92
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Severe Asthma
Trial of Simvastatin for the Treatment of Severe Asthma
This purpose of this clinical trial is to determine if a statin drug, Simvastatin, added to inhaled corticosteroids and bronchodilators can reduce systemic and airway inflammation, improve lung function and symptoms, and reduce…
- Trial name
- NCT02433535
- Testing
- Simvastatin
- Where
- United States
- Sponsor
- University of California, Davis
Grass Pollen Allergic Rhinitis
Resolution of Allergic Inflammation
After an allergen challenge, the allergic inflammatory response disappears spontaneously. The initiation of the resolution of the inflammatory response is now recognized as a dynamic process, involving active biochemical programs…
- Trial name
- NCT01992835
- Testing
- Grass pollen allergen extract
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Seasonal Allergic Rhinitis
Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis
The aim of this study is to compare the effect of montelukast and cetirizine on allergic inflammation measured by exhaled nitric oxide concentration in children with seasonal allergic rhinitis.
- Trial name
- NCT00488176
- Testing
- montelukast, cetirizine, montelukast and cetirizine
- Where
- Poland
- Volunteers
- 116 people
- Sponsor
- Medical University of Lodz
Asthma
Induced Sputum Study (0000-065)
The primary goals of this study will be to implement innovative processing and detection assays to qualify induced sputum measurements of markers of allergen-induced airway inflammation.
- Trial name
- NCT00623714
- Testing
- Comparator: fluticasone
- Volunteers
- 13 people
- Sponsor
- Merck Sharp & Dohme LLC
Airway Inflammation, Allergic Asthma
To Identify Persons Who Are Susceptible to WSP-induced Inflammation and Examine the Role of GSTM1 and Other Factors in This Susceptibility
Purpose: This screening protocol is designed to assess PMN (neutrophil) responsiveness to wood smoke particles (WSP) and the effect of the GSTM1 null genotype on this response.
- Trial name
- SmokeScreen (NCT02767973)
- Testing
- Wood Smoke Particles (WSP)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Ocular Surface Allergy, Conjunctivitis, Allergic
Treatment of Ocular Surface Inflammations
The goal of this clinical trial is to learn if topical Cyclosporine 1% works to treat severe allergic ocular surface inflammation in pediatric population.
- Conditions
- Ocular Surface Allergy, Conjunctivitis, Allergic, Blepharoconjunctivitis
- Trial name
- NCT07732855
- Testing
- Topical Cyclosporine 1%
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Allergic Conjunctivitis
AL-38583 Ophthalmic Solution for Allergic Conjunctivitis Associated Inflammation
The purpose of this study is to assess the safety and efficacy of AL-38583 in the treatment of the signs of inflammation associated with allergic conjunctivitis.
- Trial name
- NCT01001091
- Testing
- AL-38583 ophthalmic solution, AL-38583 ophthalmic solution vehicle, Dexamethasone ophthalmic suspension, 0.1%
- Volunteers
- 312 people
- Sponsor
- Alcon Research
Allergic Rhinitis, Asthma
Allergic Inflammation in Rhinitis Patients Following Nasal Allergen Challenge
Allergic rhinitis is a common condition caused by inflammation of nasal mucosa. The study was performed to gain information on this inflammation, including effect of intranasal corticosteroid treatment hereupon and potential…
- Trial name
- NCT01657097
- Testing
- INCS
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Allergic Asthma
A Study to Evaluate the Effect of Roflumilast on Airway Inflammation and Function Following Allergen Challenge in Subjects With Allergic Asthma
The study was a double-blind, placebo-controlled, crossover study to evaluate the efficacy of roflumilast on airway inflammation and function in patients with allergen-induced asthma.
- Trial name
- NCT01365533
- Testing
- Roflumilast
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- AstraZeneca
Asthma Patients
ICS+LABA Vs. ICS+LABA+Omalizumab: Impact on Asthma Control and Gene Expression
Asthma is a chronic respiratory disease characterized by airway inflammation and obstruction, leading to wheezing, breathlessness, chest tightness, and coughing.
- Trial name
- NCT06869382
- Testing
- Foster BDP/Formoterol, Omalizimab
- Where
- Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Rhinitis, Allergic, Nasal Allergy
Mometasone Furoate Nasal Spray in Italian Children
Objective Seasonal allergic rhinitis (SAR) is a common disease in childhood and characterized by type 2 inflammation, bothersome symptoms, and impaired quality of life (QoL).
- Conditions
- Rhinitis, Allergic, Nasal Allergy, Allergy Pollen, Nasal, Cytology
- Trial name
- NCT05301647
- Testing
- Nasal cytology, The validated Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ), Total symptom score (TSS)
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Rhinitis, Allergic, Seasonal, Seasonal Allergic Rhinitis
Trial With Rhinitic Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber
This study is in patients with seasonal allergic rhinitis(SAR)and will compare the effect versus placebo of repeat doses of intranasal GSK256066 using the Vienna Challenge Chamber.
- Trial name
- NCT00377728
- Testing
- GSK256066
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- GlaxoSmithKline
Airways Allergic Inflammation of Asthmatic Children
Beneficial Effects of Lactobacillus Reuteri DSM 17938 Supplementation on Asthmatic Children
Objective The aim of the trial is to evaluate the beneficial effects of the oral administration of the probiotic L. Reuteri (Reuterin®) on the airways allergic inflammation in children with mild to moderate persistent asthma.
- Trial name
- NCT01241084
- Testing
- Antileukotrienes + Lactobacillus reuteri
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Asthma, Allergic, Rhinitis,Allergic
Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis
Single centre, double-blind, placebo controlled, adaptive design, cross-over trial. The primary objective is to assess the additive effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on airway…
- Conditions
- Asthma, Allergic, Rhinitis,Allergic, Allergy
- Trial name
- MAN06 (NCT02953106)
- Testing
- Azelastine-Fluticasone Nasal
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Dundee
Allergic Rhinitis
An Exploratory Study of the Effects of a Single Dose of QAX576 (an Interleukin-13 Monoclonal Antibody) on Simulated Hayfever
This study will investigate whether a single dose QAX576 (an interleukin-13 monoclonal antibody) gives protection against a model of hayfever
- Trial name
- NCT00584584
- Testing
- QAX576
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Novartis