Clinical trials: Allergy Drug
Anxiety/Depression and Asthma
The Impact of Anxiety/Depression on the Efficacy of Asthma Control Drugs and the Construction of a Predictive Model for the Risk of Acute Asthma Attacks
The goal of this clinical trial is to explore the impact of anxiety/depression on the efficacy of asthma controller medications and to develop a risk prediction model for asthma acute exacerbations in patients with asthma.
- Trial name
- NCT07679321
- Testing
- No intervention measures
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Xiangya Hospital of Central South University
Hand-Foot Syndrome
Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome
Hand foot skin reaction (HFS) from capecitabine is one of the most common adverse events from capecitabine. Urea cream has been proved its benefit to prevent HFS from sorafenib.
- Trial name
- NCT05348278
- Testing
- Urea cream
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Mahidol University
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
Stimulant Medication Effects on Auditory Sensitivity in Teens With ADHD
The aims of this study are to evaluate auditory sensitivity in teenagers with ADHD using acoustic reflex thresholds (ART) and to examine the effects of ADHD stimulant medication on ART.
- Conditions
- Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Attention Deficit Disorder With Hyperactivity
- Trial name
- NCT04577417
- Testing
- ADHD stimulants, for example, amphetamine, dexmethylphenidate, dextroamphetamine, methylphenidate
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Asthma
Adaptation of the Pediatric Asthma Control & Communication Instrument (PACCI) in a Pediatric Emergency Department
This study examined whether the Pediatric Asthma Control and Communication Instrument for the Emergency Department (PACCI-ED), a 12-item questionnaire, can help doctors in the emergency department accurately assess a child's…
- Trial name
- NCT01895478
- Testing
- PACCI-ED use
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Rhode Island Hospital
Sarcoidosis, Pulmonary
Atorvastatin to Treat Pulmonary Sarcoidosis
This study will determine if atorvastatin (Lipitor) can help patients with pulmonary (lung) sarcoidosis and replace or reduce the need for patients to take steroids, such as prednisone.
- Trial name
- NCT00279708
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hand-foot Syndrome, Hand-foot Skin Reaction
Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction
Hand-foot syndrome (HFS) is a side effect of chemotherapy. HFS is characterized by redness, swelling, and pain on the palms of the hands and/or soles of the feet, which can progress to blistering.
- Trial name
- DermLight (NCT04979078)
- Testing
- Photobiomodulation therapy (PBMT)
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Jessa Hospital
Dermatitis, Atopic, Dermatitis
Effect of Benralizumab in Atopic Dermatitis
Atopic Dermatitis (AD), also known as eczema, is a common skin disease characterized by itchy lesions. The prevalence of AD has increased over the past few decades, with 15-30% of children and 2-10%of adults being affected.
- Conditions
- Dermatitis, Atopic, Dermatitis, Eczema, Skin Diseases
- Trial name
- NCT03563066
- Testing
- Benralizumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Head and Neck Squamous Cell Carcinoma
PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC
This is a multi-center, open-label Phase 0 substudy designed to study the localized pharmacodynamics (PD) of TAK-676 alone or in combination with Carboplatin, 5-FU, or Paclitaxel within the tumor microenvironment (TME) when…
- Trial name
- NCT06062602
- Testing
- TAK-676, Carboplatin, 5-FU
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Presage Biosciences
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Bioequivalence Study of Budesonide/Formoterol Inhalation Powder in Healthy Participants
The goal of this study is to learn if a new formulation of Budesonide/Formoterol Inhalation Powder (160μg/4.5μg), manufactured by Shanghai New Huanghe Pharmaceutical Co., Ltd., works the same as the already approved reference…
- Trial name
- BF-BE (NCT07804303)
- Testing
- Budesonide and Formoterol Fumarate Powder for Inhalation (II) (Test), Budesonide and Formoterol Fumarate Powder for Inhalation (II) (Reference)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai Xin Huanghe Pharmaceutical Co., Ltd.
Chronic Conjunctivitis, Stevens-Johnson Syndrome
Clinical Trial to Evaluate Safety and Efficacy of Cell Therapy in Patients With Cicatricial Conjuntivitis.
A phase IIa, open label, non controlled clinical trial to assess the feasibility and safety of allogeneic adipose-derived mesenchymal stem cells (ASC) in the treatment of cicatricial conjunctivitis associated with Lyell's…
- Conditions
- Chronic Conjunctivitis, Stevens-Johnson Syndrome, Lyell Syndrome, Pemphigoid
- Trial name
- CELOPHIN (NCT05520086)
- Testing
- Single Dose, Double Dose
- Where
- 8 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Carcinoma, Non-Small-Cell Lung, Lung Neoplasms
Drug-Drug Interaction Study of TAK-788 and Midazolam in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)
The purpose of this study is to characterize the effect of repeated oral administration of TAK-788 160 milligram (mg) once daily on the single oral and intravenous dose pharmacokinetics (PK) of midazolam.
- Trial name
- NCT04051827
- Testing
- Midazolam, TAK-788
- Where
- 8 sites in Australia, Netherlands and 1 more
- Volunteers
- 26 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Asthma, Aspirin-Induced
The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases
The purpose of this study is to determine the effect of aspirin desensitization on symptoms and immunologic profile of patients with aspirin-exacerbated respiratory diseases (AERD).
- Trial name
- NCT01867281
- Testing
- aspirin
- Where
- Iran
- Volunteers
- 32 people
- Sponsor
- Tehran University of Medical Sciences
Anaphylactic Reaction, Anaphylaxis
Steroid Use in Treatment of Allergic Reactions to Food
In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary.
- Conditions
- Anaphylactic Reaction, Anaphylaxis, Allergy in Children, IgE Mediated Food Allergy
- Trial name
- SAFARI (NCT07341776)
- Testing
- Antihistamines, Systemic corticosteroids, Adrenaline (rescue medication)
- Where
- 2 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Johannes Trueck
Asthma, Chest Syndrome
Azithromycin Treatment for Non-eosinophilic Chest Tightness Variant Asthma
Bronchial asthma (abbr. asthma) is one of common airway chronic inflammatory disease which usually threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Azithromycin, Effect of Drug
- Trial name
- NCT05596721
- Testing
- Azithromycin, ICS/LABA
- Where
- 13 sites in China
- Volunteers
- 248 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atopic Dermatitis
Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis
The aim of the trial is to assess Adrenal Suppression potential when pediatric subjects are administered Product 0405 for the treatment of Atopic Dermatitis
- Trial name
- 0405-01-04 (NCT01232543)
- Testing
- Product 0405
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Fougera Pharmaceuticals Inc.
Asthma, Allergy
Treatment of Ragweed-Allergic Asthma With an Immunostimulatory Drug
This study will test the effectiveness of an investigational treatment for patients with ragweed-induced asthma, sometimes called fall seasonal asthma. The treatment being tested is a series of anti-ragweed shots.
- Conditions
- Asthma, Allergy, Allergic Rhinitis, Rhinitis, Allergic, Seasonal
- Trial name
- NCT00318747
- Testing
- Amb a 1-immunostimulatory oligodeoxyribonucleotide conjugate (AIC)
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Skin Inflammation, Allergic Contact Dermatitis
Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation
The purpose of this study is to answer: how do inflammation and anti-inflammatory skin therapies work in the skin? Inflammation is a protective response from the body's immune system to injury, disease, or irritation.
- Trial name
- NCT05535738
- Testing
- Squaric Acid Dibutyl Ester, Known patch test allergens, Dupilumab
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Wei-Che Ko
Gestational Diabetes, Glucose Tolerance Impaired in Pregnancy
Food Product for Management of Gestational Diabetes
The goal of this pilot open pre-post clinical trial is to test effects of a wholegrain product in patients with newly diagnosed gestational diabetes.
- Conditions
- Gestational Diabetes, Glucose Tolerance Impaired in Pregnancy, Glucose Tolerance Impaired, Pregnancy Related
- Trial name
- NCT05917808
- Testing
- Ready-to-eat wholegrain porridge
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Hereditary Angioedema (HAE)
A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) in the Kingdom of Saudi Arabia
Hereditary angioedema (HAE) is a rare condition. It causes sudden swelling under the skin and inside the body, like in the belly, throat, or genitals.
- Trial name
- NCT07263685
- Testing
- No intervention
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Takeda
Asthma
Prospective Clinical Study on the Clinical Efficacy and Prognostic Outcome of ICS/LABA Combined With Liqin Zhike Formula in the Treatment of Cough Variant Asthma
To investigate the impact of the combination of ICS/LABA and Liqin Zhike Formula on the clinical efficacy and prognostic outcomes of cough variant asthma.
- Trial name
- NCT07272278
- Testing
- ICS+LABA, Chinese Medicine Formula
- Volunteers
- 236 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine