Clinical trials: Allogeneic Blood Transfusions
Anemia
HBOC-201 Expanded Access Protocol for Life-threatening Anemia for Whom Allogeneic Blood Transfusion is Not an Option
The purpose of this protocol is to provide treatment with HBOC-201 to patients with life-threatening anemia for whom blood is not an option.
- Trial name
- NCT02934282
- Testing
- HBOC-201
- Where
- United States
- Sponsor
- Mauricio Lynn
Blood Loss, Surgical
Evaluation of Thromboelastometry (ROTEM) During Spinal Surgery
The purpose of this study is to determine whether the use of ROTEM, during spinal surgery is effective on diminishing the total blood loss and the risk of Allogenic Transfusion of Blood Products vs control cases without ROTEM…
- Trial name
- ROTEM_SPINE (NCT02740374)
- Testing
- ROTEM, Standard of Care
- Volunteers
- 112 people
- Sponsor
- Ohio State University
Spinal Injuries, Spinal Deformity
Tranexamic Acid to Reduce Blood Loss in Spine Surgery
This study is designed to evaluate the efficacy of topical tranexamic acid to reduce perioperative blood loss, reduction in postoperative drain output and allogenic transfusion requirements.
- Trial name
- NCT02314988
- Testing
- Tranexamic Acid
- Where
- 4 sites in United States
- Volunteers
- 252 people
- Sponsor
- Columbia University
Coronary Artery Disease, Coronary Artery Bypass
Impact of Fluid Restriction Policy in Reducing the Use of Red Cells in Cardiac Surgery
The investigators' hypothesis is that restriction of circulating fluids in comparison to a liberal fluid administration policy would lead to a reduction of allogenic red blood cells exposure in patients undergoing cardiopulmonary…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Erythrocyte Transfusion
- Trial name
- NCT00600704
- Testing
- Fluid Restriction Policy, Free fluid infusion
- Where
- Greece
- Volunteers
- 192 people
- Sponsor
- Larissa University Hospital
Blood Transfusion, Cardiac Surgery
ICU Cell Saver to Reduce Blood Transfusions in Cardiac
PURPOSE: Autotransfusion devices may be employed in cardiac surgery to decrease allogenic blood requirements. Limitations of previous trials include the use of cell saver systems in selected high risk patients only or the lack of…
- Trial name
- NCT00950547
- Testing
- CARDIOPAT, Traditional Chest Drains
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Cardiochirurgia E.H.
Blood Transfusion
Allogenic Blood Transfusion During Elective Open Abdominal Aortic Surgery
Open surgery on the abdominal aorta is a high risk procedure associated with an intravascular volume blood loss and thereby, with high requirement for blood and blood product transfusion.
- Trial name
- NCT03891303
- Testing
- Allogenic blood transfusion (ABT)
- Volunteers
- 426 people
- Sponsor
- Clinic for Cardiovascular Diseases Magdalena
Cancer, Surgery
Unmodified Versus Leuko-reduced Allogeneic Red Blood Cells Transfusion in Cancer Patients
There is evidence to suggest that red blood cell concentrate (RBC) transfusion may have immunomodulatory effects. The aim of this randomized single-center trial is to compare immune responses in patients undergoing cancer surgery…
- Trial name
- NCT00180869
- Testing
- transfusion of allogeneic red blood cell concentrate, transfusion of leuko-reduced red blood cell concentrate
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Spinal Fusion, Transfusion
Effect of Intraoperative Allogeneic Blood Transfusion on Postoperative Pulmonary Complications
Elective spine surgery is associated with a high incidence of perioperative complications, including peri- and postoperative pulmonary complications (PPCs), which occur in nearly 4% of patients.
- Conditions
- Spinal Fusion, Transfusion, Pulmonary Complication
- Trial name
- NCT05661838
- Testing
- transfusion
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Transfusion
Use of Cell Salvage Post-operatively in Infants to Decrease Use of Allogeneic Blood Product Transfusions
Transfusion of washed intra-operative cell salvage post-operatively in the PCICU can be performed safely without increased risk of bleeding or release of inflammatory mediators.
- Trial name
- cell salvage (NCT01211366)
- Testing
- Cell Saver RBCs, Conventional volume infusion
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Rochester
Platelets, Bleeding
Delayed Cold-Stored Platelets -PLTS-1
PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada.
- Conditions
- Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PLTS-1 (NCT06147531)
- Testing
- Delayed Cold-Stored Buffy Coat Platelets, Room Temperature Buffy Coat Platelets
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Incompatible Blood Transfusion, Immune Defect
Immunomodulation Effect of Blood Transfusion
An increasing number of publications have demonstrated that homologous (allogeneic) blood transfusion impairs outcome in cancer and non-cancer patients.
- Conditions
- Incompatible Blood Transfusion, Immune Defect, Surgery
- Trial name
- NCT02140216
- Testing
- No blood transfusion, Day 0 blood transfusion, Day 1 or 2 blood transfusion
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Complications
Effect of Intravenous Iron Supplementation in Reducing Allogenic Blood Transfusion
A total of 80 patients will be randomly allocated into 2 groups, group A and placebo group using concealed envelope method.Group A patients (n= 40)will receive single dose intravenous infusions of iron isomaltoside 1000 mg over…
- Trial name
- NCT04061655
- Testing
- Iron Isomaltoside 1000
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Liver Transplant; Complications, Bleeding
Viscoelastic Tests-Guided Therapy In Liver Transplantation
BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation.
- Conditions
- Liver Transplant; Complications, Bleeding, Hemostatic Disorder
- Trial name
- VETLT (NCT03756948)
- Testing
- Usual Care, Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates
- Volunteers
- 237 people
- Sponsor
- Hospital Israelita Albert Einstein
Allogenic Transfusion, Perioperative Anaemia
Cross Iron (Comparative Randomized Oral Versus Systemic IRON)
Patients were recruited at the scheduled preoperative visit for hip or knee arthroplasty. If the haemoglobin (Hb) level was below 13 g/dl with no contraindication to iron supplementation the patients were randomized to the oral…
- Conditions
- Allogenic Transfusion, Perioperative Anaemia, Knee Arthroplasty, Hip Arthroplasty
- Trial name
- Cross Iron (NCT02496377)
- Testing
- ferrous glycine sulfate Tardyferon, Epoetin Alfa, ferric carboxymaltose Ferinject
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Kidney Cancer
Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer
The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT). The primary objective is to reduce the number of units of allogenic blood transfusion in locally advanced kidney cancer (≥ cT2).
- Trial name
- RESTRICT (NCT04922307)
- Testing
- Blood Sparing Protocol, Standard Blood Replacement
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanderbilt University Medical Center
Cardiac Arrest
Goal-orientated Coagulation Management in Hypothermic Cardiac Arrest Surgery
Cardiac surgery including hypothermic cardiac arrest (HCA) commonly involves perioperative transfusion of allogeneic blood products which is associated with increased morbidity and mortality.
- Trial name
- NCT01446354
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Scoliosis; Adolescence, Bleeding
The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery
Allogeneic blood products transfusions are often necessary to treat perioperative bleeding in patients undergoing complex scoliosis surgeries.
- Conditions
- Scoliosis; Adolescence, Bleeding, Surgery
- Trial name
- NCT03183479
- Testing
- Fibrinogen Concentrate Human, Normal saline
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Peking Union Medical College Hospital
Platelet Aggregation, Blood Transfusion
Validation of a Red Blood Cell Transfusion Prediction Model in a Low Transfusion Rate Population.
The transfusion risk and clinical knowledge (TRACK) allogeneic blood transfusion prediction model was developed more than ten years ago and demonstrated good discriminative ability in patients with increased risk for allogeneic…
- Trial name
- TRACK-TCT (NCT05581238)
- Testing
- TRACK-TCT
- Where
- Netherlands
- Volunteers
- 6,428 people, healthy volunteers welcome
- Sponsor
- Medisch Spectrum Twente
Myocardial Injury, Acuter Kidney Injury
Impact of Perioperative Allogeneic Red Blood Cell Transfusion on Postoperative Myocardial Injury After Liver Resection
We aimed to explore the influence of ABT on the incidence of MINS, AKI, and overall prognosis among advanced-age HCC patients who underwent hepatectomy
- Trial name
- NCT07125612
- Volunteers
- 487 people
- Sponsor
- Hao Li
Revision Total Hip Arthroplasty (RTHA)
Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty
Sixty patients aged between 60 and 75 years old of both sex of ASA physical status I and II were included in this randomized study who were divided into the study group of 30 patients who had been transfused autologous blood and…
- Trial name
- NCT02747615
- Testing
- transfused pre-operatively donated autologous blood., intravenous tranexamic acid (TXA) infusion, transfused only allogeneic blood.
- Volunteers
- 60 people
- Sponsor
- Ain Shams University