Clinical trials: Allogenic Transfusion
Arthroplasty, Replacement, Knee, Blood Transfusion, Autologous
A Clinical Study to Investigate if Transfusion of Patients Own Shed Blood Improves the Immunological Status in Comparison to Transfusion of Donor Blood ("Bank Blood")
The primary objective of the study is to compare the immunological status after either autologous blood transfusion as administered by Bellovac® ABT or allogenic blood transfusion, with regards to change in Natural Killer (NK)…
- Conditions
- Arthroplasty, Replacement, Knee, Blood Transfusion, Autologous, Blood Transfusion
- Trial name
- NCT00839241
- Testing
- Bellovac ABT, Allogenic Blood Transfusion
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Wellspect HealthCare
Coagulation Disorder, Blood
Blood Transfusion and Postoperative Outcome Before and After Implementing a Coagulation Management Algorithm
Implementing coagulation management algorithms based on Point-of-care (POC) testing devices such as thromboelastography (TEG) or rotational thromboelastometry (ROTEM) have been shown to reduce transfusion rates and the occurrence…
- Trial name
- SONALG (NCT03482128)
- Testing
- Coagulation management guided by SONOCLOT, Standard coagulation management
- Where
- Switzerland
- Volunteers
- 1,754 people
- Sponsor
- Triemli Hospital
Allogeneic Granulocyte Donation
Improving White Blood Cell Collection From Healthy Donors
Background: White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells.
- Trial name
- NCT01553214
- Testing
- Filgrastim, Dexamethasone
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Anemia, Iron Deficiency Anemia
The Effect of Combined Iron Protocols on Perioperative Allogeneic Transfusion
The goal of this clinical trial is to learn if a combined iron supplementation regimen can reduce the need for blood transfusions in adults with iron-deficiency anemia undergoing major elective cardiac surgery.
- Conditions
- Anemia, Iron Deficiency Anemia, Perioperative, Transfusion
- Trial name
- CIPAT (NCT06012760)
- Testing
- Iron sucrose, Human Erythropoietin Injection, Vitamin C, Standard Medical Care
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sickle Cell Disease, Hemoglobin SC
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOP
Patients are being asked to participate in this study because they have severe sickle cell anemia (SCD) with or without the beta thalassemia trait.
- Trial name
- SCALLOP (NCT00578344)
- Testing
- Busulfan, Campath 1H, Cyclophosphamide and MESNA
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Tami D. John
Hemostasis
Three Dose Regimen of Tranexamic Acid in Cardiac Surgery
Tranexamic acid is thought to be a promising substitute for aprotinin when the latter has seceded in 2007. Yet the ideal dosage and dosing regimen of tranexamic acid in cardiopulmonary bypass cardiac surgery in Chinese population…
- Trial name
- NCT01060176
- Testing
- Tranexamic Acid, Saline Solution
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cardiopulmonary Bypass, Obesity
Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
Standard Heparin management, based on total body weight, is not well established for obese patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Trial name
- NCT03302195
- Testing
- Heparin, cardiopulmonary bypass pump flow rate
- Where
- Canada
- Volunteers
- 410 people
- Sponsor
- Laval University
Anemia of Prematurity
Autologous Cord Blood Transfusion in Preterm Infants
The purpose of this study is to investigate the efficacy and safety of autologous cord blood transfusions in very-low-birth-weight premature infants, and to evaluate the developmental outcomes of the infants who received…
- Trial name
- NCT02101086
- Testing
- Blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Ankara University
Cancer, Surgery
Unmodified Versus Leuko-reduced Allogeneic Red Blood Cells Transfusion in Cancer Patients
There is evidence to suggest that red blood cell concentrate (RBC) transfusion may have immunomodulatory effects. The aim of this randomized single-center trial is to compare immune responses in patients undergoing cancer surgery…
- Trial name
- NCT00180869
- Testing
- transfusion of allogeneic red blood cell concentrate, transfusion of leuko-reduced red blood cell concentrate
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Complications
Effect of Intravenous Iron Supplementation in Reducing Allogenic Blood Transfusion
A total of 80 patients will be randomly allocated into 2 groups, group A and placebo group using concealed envelope method.Group A patients (n= 40)will receive single dose intravenous infusions of iron isomaltoside 1000 mg over…
- Trial name
- NCT04061655
- Testing
- Iron Isomaltoside 1000
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
MDS-EB
Allogenic NK Cell Transfusion Azacitidine MDS-EB
The aim of this investigation was to assess safety and efficacy of allogenic NK cells therapy for refractory MDS-EB.
- Trial name
- NCT04599426
- Testing
- Allogeneic NK cell regimen group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Second Hospital of Shandong University
Surgery
Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs In Laparotomy
This study is aimed to determine if acute normovolemic hemodilution (ANH), an established blood conservation technique, reduces the requirement for allogeneic blood transfusion in operations with prediction of surgical bleeding…
- Trial name
- ANH (NCT02290964)
- Testing
- ANH
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Padjadjaran
Cerebral Palsy
Allogenic Cord Blood Transfusion in Patients With Cerebral Palsy
Cerebral palsy is a disorder of movement and posture resulted from a non-progressive lesion or injury of the immature brain. It is a leading cause of childhood onset disability.
- Trial name
- NCT03826498
- Testing
- CP CB-MNC injection, Standard therapy
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Revision Total Hip Arthroplasty (RTHA)
Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty
Sixty patients aged between 60 and 75 years old of both sex of ASA physical status I and II were included in this randomized study who were divided into the study group of 30 patients who had been transfused autologous blood and…
- Trial name
- NCT02747615
- Testing
- transfused pre-operatively donated autologous blood., intravenous tranexamic acid (TXA) infusion, transfused only allogeneic blood.
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Aplastic Anemia
CK0801 for Treatment of Aplastic Anemia
This Phase 2, multicenter, open-label study is evaluating CK0801 for the treatment of aplastic anemia in adults with persistent transfusion dependence after at least one prior line of therapy or intolerance to standard-of-care…
- Trial name
- NCT07499102
- Testing
- CK0801
- Volunteers
- 12 people
- Sponsor
- Cellenkos, Inc.
Myeloid Malignancy, Bone Marrow Failure Syndrome
Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation
The purpose of this study is to find out what effects, good and/or bad, the addition of clofarabine, a new chemotherapy agent, to a standard busulfan and fludarabine conditioning treatment has.
- Conditions
- Myeloid Malignancy, Bone Marrow Failure Syndrome, Transfusion-dependent Red Blood Cell (RBC) Defect, Congenital Immunodeficiency
- Trial name
- NCT01596699
- Testing
- Alemtuzumab, Busulfan, Fludarabine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Infections
Stored RBC Transfusion and Immonomodulation
Transfusion of RBC is associated with post operative infections. Our hypothesis is that stored blood could be related with increased post operative infection risk.
- Trial name
- NCT01976234
- Testing
- Fresh RBC, Old RBC
- Where
- Italy
- Volunteers
- 181 people
- Sponsor
- Università degli Studi di Ferrara
Hemoglobinopathies, Sickle Cell Disease
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies
The purpose of this study is to determine if treatment with reduced-dose busulfex, fludarabine and alemtuzumab (CAMPATH) followed by sten cell infusion will allow for donor stem cells to grow in patients with hemoglobinopathies…
- Conditions
- Hemoglobinopathies, Sickle Cell Disease, Thalassemia
- Trial name
- NCT00153985
- Testing
- Busulfex, Fludarabine, Alemtuzumab
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Dana-Farber Cancer Institute
Coronary Artery Disease, Coronary Artery Bypass
Impact of Fluid Restriction Policy in Reducing the Use of Red Cells in Cardiac Surgery
The investigators' hypothesis is that restriction of circulating fluids in comparison to a liberal fluid administration policy would lead to a reduction of allogenic red blood cells exposure in patients undergoing cardiopulmonary…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Erythrocyte Transfusion
- Trial name
- NCT00600704
- Testing
- Fluid Restriction Policy, Free fluid infusion
- Where
- Greece
- Volunteers
- 192 people
- Sponsor
- Larissa University Hospital
Coxarthrosis
Effects of the Sangvia Blood Collection System on Postoperative Infections in Orthopedic Patients
The purpose of this study is to compare the infection rate in patients receiving/not receiving their own blood, collected during surgery, during and after orthopedic surgery.
- Trial name
- NCT01725724
- Testing
- Autologous blood transfusion, Allogeneic blood transfusion
- Where
- 4 sites in Norway
- Volunteers
- 162 people
- Sponsor
- Haukeland University Hospital