Clinical trials: Allogenic Transfusion, active
Graft Failure, Sickle Cell Disease
Allo HSCT for High Risk Hemoglobinopathies
A single center, open label, interventional, phase II trial for donor transplant for high risk hemoglobinopathies and other red cell transfusion dependent disorders utilizing allogeneic hematopoietic stem cell transplantation…
- Conditions
- Graft Failure, Sickle Cell Disease, Hemoglobinopathies
- Trial name
- NCT06872333
- Testing
- Alemtuzumab, Total Body Irradiation, Cell Infusion
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Allogeneic Granulocyte Donation
Improving White Blood Cell Collection From Healthy Donors
Background: White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells.
- Trial name
- NCT01553214
- Testing
- Filgrastim, Dexamethasone
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiac Surgical Procedures, Blood Transfusion
Systematic Intraoperative Cell Salvage in On-Pump Cardiac Surgery Within a Mature Patient Blood Management Programme
The goal of this observational study is to learn if cell salvage lowers the need for donor blood in adults having planned heart surgery with a heart-lung machine.
- Conditions
- Cardiac Surgical Procedures, Blood Transfusion, Anemia, Postoperative Hemorrhage
- Trial name
- SPARE (NCT07922486)
- Testing
- Systematic intraoperative cell salvage
- Where
- Portugal
- Volunteers
- 657 people
- Sponsor
- Aveiro University
Bleeding, Platelets
Autologous Cold-stored Apheresis Platelets
The Auto-PLTS Study is a single-centre trial performed at Toronto General Hospital (TGH) that uses a randomized, patient preference design.
- Conditions
- Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- Auto-PLTS (NCT07064954)
- Testing
- Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Sickle Cell Disease
Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)
The investigators propose to determine the engraftment and transplant related morbidity and mortality after a non-myeloablative allogeneic hematopoietic stem cell transplant protocol using immune- suppressive agents and low-dose…
- Trial name
- NCT01499888
- Testing
- Allogeneic Non-Myeloablative Stem Cell Transplantation, Alemtuzumab, Sirolimus
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Illinois Chicago
Anemia, Iron Deficiency Anemia
The Effect of Combined Iron Protocols on Perioperative Allogeneic Transfusion
The goal of this clinical trial is to learn if a combined iron supplementation regimen can reduce the need for blood transfusions in adults with iron-deficiency anemia undergoing major elective cardiac surgery.
- Conditions
- Anemia, Iron Deficiency Anemia, Perioperative, Transfusion
- Trial name
- CIPAT (NCT06012760)
- Testing
- Iron sucrose, Human Erythropoietin Injection, Vitamin C, Standard Medical Care
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aplastic Anemia
CK0801 for Treatment of Aplastic Anemia
This Phase 2, multicenter, open-label study is evaluating CK0801 for the treatment of aplastic anemia in adults with persistent transfusion dependence after at least one prior line of therapy or intolerance to standard-of-care…
- Trial name
- NCT07499102
- Testing
- CK0801
- Volunteers
- 12 people
- Sponsor
- Cellenkos, Inc.
Spinal Injuries, Spinal Deformity
Tranexamic Acid to Reduce Blood Loss in Spine Surgery
This study is designed to evaluate the efficacy of topical tranexamic acid to reduce perioperative blood loss, reduction in postoperative drain output and allogenic transfusion requirements.
- Trial name
- NCT02314988
- Testing
- Tranexamic Acid
- Where
- 4 sites in United States
- Volunteers
- 252 people
- Sponsor
- Columbia University
Diabetic Wounds, Platelet Rich Plasma
Allogeneic vs Autologous PRP for Diabetic Wounds in Renal Dysfunction: a Randomized Controlled Trial
Diabetic wounds are difficult to heal. Autologous platelets in diabetic patients with renal insufficiency have poor function. Allogeneic platelet plasma has a promising application prospect.
- Conditions
- Diabetic Wounds, Platelet Rich Plasma, Allogeneic Blood Transfusions, Renal Dysfunction
- Trial name
- NCT07020559
- Testing
- allogeneic platelet plasma, autologous platelet plasma
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University Third Hospital
Platelets, Bleeding
Delayed Cold-Stored Platelets -PLTS-1
PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada.
- Conditions
- Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PLTS-1 (NCT06147531)
- Testing
- Delayed Cold-Stored Buffy Coat Platelets, Room Temperature Buffy Coat Platelets
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Cardiopulmonary Bypass, Obesity
Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
Standard Heparin management, based on total body weight, is not well established for obese patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Trial name
- NCT03302195
- Testing
- Heparin, cardiopulmonary bypass pump flow rate
- Where
- Canada
- Volunteers
- 410 people
- Sponsor
- Laval University
Kidney Cancer
Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer
The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT). The primary objective is to reduce the number of units of allogenic blood transfusion in locally advanced kidney cancer (≥ cT2).
- Trial name
- RESTRICT (NCT04922307)
- Testing
- Blood Sparing Protocol, Standard Blood Replacement
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanderbilt University Medical Center
Acute Normovolemic Hemodilution, Bone Tumor
The Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of intraoperative allogenetic blood transfusion has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone cancer surgery.
- Conditions
- Acute Normovolemic Hemodilution, Bone Tumor, Goal-Directed Fluid Therapy, Transfusion
- Trial name
- NCT06459141
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine