Clinical trials: Als
Amyotrophic Lateral Sclerosis
A New Eye-based Communication Device for ALS Patients
Eighteen ALS patients will be trained to control a new communication device (Eye On Line: EOL) that permit over smooth eye movements to generate digits, letters, words or drawing at will.
- Trial name
- ELY-SLA (NCT02313402)
- Testing
- EOL (Eye On Line)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis
Electrophysiology and Ultrasound of Respiratory Muscles and Respective Nerves to Predict Respiratory Insufficiency in ALS
Respiratory insufficiency is a common complication in amyotrophic lateral sclerosis (ALS). Survival can be prolonged with noninvasive ventilation (NIV).
- Trial name
- NCT06841341
- Testing
- electromyography, ultrasonography, Arterial blood gas analysis
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Jagiellonian University
Amyotrophic Lateral Sclerosis
A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)
The purpose of this study is to assess the long-term safety and tolerability of reldesemtiv in patients with ALS who have successfully completed dosing in the Phase 3 clinical trial, CY 5031 (also known as COURAGE-ALS)
- Trial name
- NCT05442775
- Testing
- Reldesemtiv
- Where
- 41 sites in United States, Australia and 7 more
- Volunteers
- 71 people
- Sponsor
- Cytokinetics
ALS
Evaluation of Metabolomic Analysis in Early Diagnosis of ALS
This project is expected to answer the question of interest assays of metabolites in the CSF as a tool for early diagnosis and should show whether it is possible or not to use such markers in the blood or urine.
- Trial name
- METABALS (NCT01962311)
- Testing
- lumbar puncture
- Where
- 6 sites in France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis, Nervous System Diseases
A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers
The purpose of this study is to collect biofluid samples for the banking and usage in ALS research. Through comparison of these samples, the researchers hope to learn more about the underlying cause of ALS, as well as find unique…
- Conditions
- Amyotrophic Lateral Sclerosis, Nervous System Diseases, Sclerosis, Motor Neuron Disease
- Trial name
- NCT01495390
- Where
- 6 sites in United States
- Volunteers
- 139 people
- Sponsor
- Massachusetts General Hospital
Amyotrophic Lateral Sclerosis
Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis
The purpose of the study is to determine whether lithium is safe and effective in the treatment of ALS
- Trial name
- LISLA (NCT00925847)
- Testing
- lithium
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis
In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS)
The investigators aim at exploring the differential/topographical in-situ expression of cytokines in the central nervous system (CNS) of patients who died with amyotrophic lateral sclerosis (ALS), using archived histopathology…
- Trial name
- NCT02582385
- Testing
- in-situ cytokine expression
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Brugmann University Hospital
Amyotrophic Lateral Sclerosis (ALS)
Personalized Antisense Oligonucleotide Therapy for Participants With TARDBP ALS
This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for participants with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in TARDBP.
- Trial name
- NCT07743268
- Testing
- nL-TARDB-006
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- n-Lorem Foundation
Radiation Induced Dermatitis
Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer
The standard treatment for early-stage breast cancer is breast-conserving surgery followed by adjuvant radiation therapy to the whole breast.
- Trial name
- NCT01513278
- Testing
- APN201
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Apeiron Biologics
Superoxide Dismutase 1-Amyotropic Lateral Sclerosis
Expanded Access Program for Tofersen in Participants With Superoxide Dismutase 1-Amyotropic Lateral Sclerosis
The objective of this early access program (EAP) is to provide access to tofersen to eligible participants with amyotrophic lateral sclerosis (ALS) associated with a mutation in the superoxide dismutase 1 (SOD1) gene prior to an…
- Trial name
- NCT04972487
- Testing
- Tofersen
- Where
- 19 sites in United States
- Sponsor
- Biogen
Amyotrophic Lateral Sclerosis
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial
The purpose of this multicenter study is to determine if insulin-like growth factor-1 (IGF-I) slows the progressive weakness in amyotrophic lateral sclerosis (ALS) patients.
- Trial name
- NCT00035815
- Testing
- Insulin like growth factor, type 1
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 330 people
- Sponsor
- Mayo Clinic
Amyotrophic Lateral Sclerosis, Neurodegenerative Disease
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular condition characterized by weakness, muscle wasting, fasciculations and increased reflexes.
- Conditions
- Amyotrophic Lateral Sclerosis, Neurodegenerative Disease, Motor Neuron Disease
- Trial name
- BCI (NCT00718458)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Amyotrophic Lateral Sclerosis, Lou Gehrig Disease
MRG-001 in Patients With Amyotrophic Lateral Sclerosis
The proposed study is an Open-Label, Single-Dose Study to Assess the Safety, and Pharmacodynamics (PD) signals of MRG-001 in Patients with Amyotrophic Lateral Sclerosis (ALS).
- Conditions
- Amyotrophic Lateral Sclerosis, Lou Gehrig Disease, Motor Neuron Disease, Motor Neuron Atrophy
- Trial name
- NCT06315608
- Testing
- MRG-001
- Volunteers
- 10 people
- Sponsor
- MedRegen LLC
ALS (Amyotrophic Lateral Sclerosis)
Extended Study of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation
This study primarily evaluates the safety, tolerability, and efficacy of RAG - 17 in adult ALS patients with SOD1 - mutated genes in the real - world setting.
- Trial name
- NCT07077668
- Testing
- A sterile aqueous solution of RAG - 17 preparation (sodium salt)
- Volunteers
- 10 people
- Sponsor
- Beijing Tiantan Hospital
Spinal Cord Injury, ALS (Amyotrophic Lateral Sclerosis)
Clinical Outcome Assessment for AT & BCI
Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers.
- Trial name
- NCT07407725
- Testing
- Eye Tracker, Mouth Operated Joystick, Non-invasive electroencephalogram (EEG) Headset
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Amyotrophic Lateral Sclerosis
Quantitative Analysis of Precise Brain Volume in Amyotrophic Lateral Sclerosis
Using the original MRI images of 16 ALS patients and 16 normal controls matched by gender, age and education level in the previous study, the differences of brain volume in different parts of ALS patients and normal controls, and…
- Trial name
- NCT04952025
- Testing
- Diagnostic criteria
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking University Third Hospital
Amyotrophic Lateral Sclerosis
Growth Hormone in Amyotrophic Lateral Sclerosis
Several drugs have been proposed for ALS. These drugs included: Topiramate, Lamotrigine, creatine, Vit. E, Pentoxifylline, etc. Although most of the trials showed a positive trend, none of them reached a statistically significant…
- Trial name
- NCT00635960
- Testing
- Growth Hormone (Somatropin)
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
ALS, Amyotrophic Lateral Sclerosis
Cortex Changes in Real/Imagined Movements in Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to track areas of the brain, via functional magnetic resonance imaging (fMRI), that retain structural and functional integrity throughout the lifespan of people with amyotrophic lateral sclerosis…
- Trial name
- NCT00809224
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Amyotrophic Lateral Sclerosis ALS
ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments
GenieUs developed an analysis platform that will be tested to separate study participants with ALS into four categories based on blood work.
- Trial name
- NCT06429059
- Testing
- Astaxanthin, Protandim, Melatonin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Amyotrophic Lateral Sclerosis, Dietary Habits
Evaluating the Potential of the Diet as Disease Modifier in Amyotrophic Lateral Sclerosis (JERN_ALS)
The proposed observational trial will collect substantial data concerning dietary intake documented by ALS patients complemented by the analysis of fatty acid distribution in erythrocyte lipids.
- Conditions
- Amyotrophic Lateral Sclerosis, Dietary Habits, Disorder of Fatty Acid Metabolism
- Trial name
- JERN_ALS (NCT02572479)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Jena