Clinical trials: Alteration of Cognitive Function, open to volunteers
Aging, Alzheimer Disease
Exercise to Improve Brain Health in Older African Americans
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.
- Conditions
- Aging, Alzheimer Disease, Healthy Aging, Cognitive Change
- Trial name
- NCT05597124
- Testing
- Cardio-Dance Fitness, Strength, Flexibility & Balance
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cognitive Change, Metabolic Syndrome, Protection Against
Nutritional Intervention for Sustaining Health (NURISH) Trial
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in…
- Conditions
- Cognitive Change, Metabolic Syndrome, Protection Against, Diet, Healthy
- Trial name
- NCT06437860
- Testing
- MIND Diet, Control Diet
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
PARKINSON DISEASE (Disorder)
Whole-Body Photobiomodulation for Motor and Cognitive Changes in Parkinson's Disease
This study aims to exploratorily evaluate the extent of motor and cognitive changes, as well as the safety, resulting from approximately 10 weeks of whole-body photobiomodulation (PBM) therapy (about three sessions per week, once…
- Trial name
- PBM (NCT07271927)
- Testing
- Photobiomodulation
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Pusan National University Yangsan Hospital
Cognitive Change
Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations.
- Trial name
- NCT05303428
- Testing
- Neuromodulation with low-intensity focused ultrasound
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Multiple Sclerosis, Cognitive Change
Remote Evaluation of MIND Diet
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in…
- Conditions
- Multiple Sclerosis, Cognitive Change, Nutrition, Healthy
- Trial name
- REMIND (NCT06450977)
- Testing
- MIND Diet, Control Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois at Urbana-Champaign
Cognition Disorder, Alzheimer Disease
REPAIR Sleep Study
The goal of this study is to learn whether a videoconference-delivered CBT-I program (REPAIR Sleep) can improve sleep and psychological well-being in caregiver-PLwD dyads.
- Trial name
- NCT07572565
- Testing
- REPAIR Sleep, Healthy Living
- Volunteers
- 120 people
- Sponsor
- Emory University
Schizophrenia and Related Disorders, Sleep Disturbance
SPARK Healthy Sleep
SPARK-Healthy Sleep is a digital mental health intervention designed to help college students who may be at risk for psychosis and experience sleep problems.
- Trial name
- SPARK (NCT07119268)
- Testing
- SPARK Healthy Sleep
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Indiana University
Heat Stress, Physiological Stress
Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults
While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289/EHP11651), this guideline has not been verified in young, habitually active adults.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07267598
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Obstructive Sleep Apnea, Sleep Disorder
Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy
This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder, Well-Being, Psychological, Cognitive Impairment
- Trial name
- MULTI-OSAS (NCT06312956)
- Testing
- Continuous Positive Airway Pressure Ventilotherapy
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Istituto Auxologico Italiano
Cognitive Change
COgnitive Dynamics in Early Childhood
The goal of this accelerated longitudinal observational cohort study is to advance our understanding of cognitive variability in children aged 7 to 10 at first measurement.
- Trial name
- CODEC (NCT06330090)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Microbial Colonization, Atopic Dermatitis
Nationwide Research on the Rewilding of Kindergarten Yards
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.
- Conditions
- Microbial Colonization, Atopic Dermatitis, Asthma in Children, Allergy
- Trial name
- Vahvistu (NCT06390878)
- Testing
- Biodiversity, Playground equipment
- Where
- 2 sites in Finland
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Ovarian Cancer, Cognitive Change
Cognitive Impact of Neoadjuvant Chemotherapy for Gynecologic Cancers
The purpose of this research is to assess several components of cognition in patients recently diagnosed with advanced epithelial ovarian cancer and who will be undergoing neoadjuvant chemotherapy for treatment of the cancer.
- Trial name
- NCT07125209
- Testing
- Patient Reported Outcomes Assessment, Cognitive and General Health Assessments
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Wisconsin, Madison
Cancer, Cachexia
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aims to answer are: 1.
- Conditions
- Cancer, Cachexia, Cachexia-Anorexia Syndrome, Appetite Loss
- Trial name
- CANCOG (NCT06112964)
- Testing
- MRI/ Functional MRI, Self-reported questionnaires, Computer based tasks
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Dementia Prevention, Subjective Cognitive Impairment
The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia
This study will recruit participants at risk for dementia to participate in an online educational program called Brain Health PRO (BHPro).
- Conditions
- Dementia Prevention, Subjective Cognitive Impairment, Mild Cognitive Impairment, Cognitive Change
- Trial name
- BHPROOF (NCT07364019)
- Testing
- Brain Health PRO
- Where
- Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Heat Stress, Physiological Stress
Heat Stress in Individuals With Schizophrenia
Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07383324
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa