Clinical trials: Altered Taste
Healthy Diet
Monell USDA Taste Test Study
Overconsumption of carbohydrates has been implicated as a cause of significant public health problems including obesity and diabetes. The most effective approach to alter dietary pattern and improve public health is unknown.
- Trial name
- MUTT (NCT04079855)
- Testing
- Diet composition 1, Diet composition 2, Diet composition 3
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- David Baer
Head and Neck Cancer
Therapy-Associated Saliva and Taste Change Evaluation (TASTE) in Head & Neck Cancer Patients Undergoing Radiotherapy
One of the main side effects of radiation therapy to the head and neck region is altered taste sensation. This causes significant morbidity and has profound effects on the quality of life (QoL) of patients.
- Trial name
- TASTE (NCT06444776)
- Testing
- Repetitive (semi-)objective and subjective taste, smell, and saliva analysis
- Where
- 3 sites in Switzerland
- Volunteers
- 150 people
- Sponsor
- Sonja Stieb, MD
PCOS, Semaglutide
The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity
The purpose of the study is to explore the effects of GLP-1 receptor agonist (GLP-1 RA) semaglutide on modulation of taste sensitivity, tongue tissue transcriptome, modulation of neural response in central reward processing…
- Conditions
- PCOS, Semaglutide, Taste, Altered, Tongue Tissue Transcriptome
- Trial name
- NCT04263415
- Testing
- Semaglutide
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Taste Disorders, Orthodontic Appliance Complication
Evaluation of Taste Sensation Changes During Fixed Orthodontic Treatment
The aim of this study is to determine the changes in taste perception that may occur before and after the initiation of treatment in patients undergoing fixed orthodontic treatment.
- Conditions
- Taste Disorders, Orthodontic Appliance Complication, Malocclusion
- Trial name
- TASTEFIXED (NCT06989736)
- Testing
- Taste Test
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Biruni University
Cancer, Anorexia
Orexigenic Therapy With Delta-9-tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study
To investigate delta-9-tetrahydrocannabinol's (THC) ability to increase food intake and improve food enjoyment for advanced cancer patients with taste and/or smell (chemosensory) abnormalities.
- Conditions
- Cancer, Anorexia, Taste Disorders, Olfactory Disorders
- Trial name
- NCT00316563
- Testing
- Marinol (Dronabinol)
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Alberta Health services
Pediatric Obesity
Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children
This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.
- Trial name
- NCT04600648
- Testing
- Serum insulin level, Serum Leptin test
- Sponsor
- State University of New York at Buffalo
Dysphagia, Stroke
Changes in Sensitivity, Taste and Smell in Stroke Patients
This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients.
- Trial name
- 5S (NCT03240965)
- Testing
- FEES (flexible endoscopic evaluation of swallowing), Sensitivity threshold, Taste-/smell-test
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Cancer Patients, Taste Disorders
New Food Solutions for Cancer Patients
The ONCOFOOD project aims to design and develop new innovative food solutions for cancer patients, taking into account not only their nutritional requirements but also their sensory changes, promoting eating pleasure and…
- Conditions
- Cancer Patients, Taste Disorders, Food Selection
- Trial name
- Oncofood (NCT04302792)
- Testing
- Texture-modified foods for cancer patients (Stage 2), Taste-optimised foods for cancer patients (Stage 3)
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Reading
COVID-19, Anosmia
Finding Out if COVID-19 Infection Can be pREdicted by ChAnges in Smell and/or Taste
The FORECAST Study is an observational cohort study looking at two cohorts of patients presenting with COVID-19: a general public cohort, aiming to investigate if new loss or reduced sense of smell and/or taste are early signs of…
- Trial name
- FORECAST (NCT04377815)
- Testing
- General Public cohort
- Where
- 2 sites in United Kingdom
- Volunteers
- 569 people, healthy volunteers welcome
- Sponsor
- University College, London
Taste, Altered
Flavoring Oral Contrast for MR Enterography
To determine if patient satisfaction, participation, and image quality improves with flavored oral contrast for MR enterography.
- Trial name
- NCT02617576
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Taste, Altered
Relationship Between MUC1 Expression and Gustatory Function in Postmenopausal Females
50 females will be included in this study. they will be divided into 2 groups (study group which will include 25 postmenopausal females - and control group which will include premenopausal females) For testing gustatory function…
- Trial name
- NCT04606524
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- October 6 University
Taste Disorders
Changes in Sense of Taste of Patients Submitted to Hematopoietic Stem Cell Transplantation
During conditioning with chemotherapy and radiotherapy for the transplantation of hematopoietic stem cells (HSCT), oral changes, such as mucositis, xerostomia infections and dysgeusia may occur.
- Trial name
- NCT03498950
- Testing
- laser therapy
- Volunteers
- 80 people
- Sponsor
- Fernanda de Paula Eduardo
Lean Body Mass, Cannabis
The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy
An intervention study on the effect of cannabidiol on lean body mass in cancer patients receiving chemotherapy, at the department of Clinical Oncology at Zealand University Hospital, Roskilde, Denmark.
- Conditions
- Lean Body Mass, Cannabis, Cancer, Nausea
- Trial name
- NCT04585841
- Testing
- Cannabidiol
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Copenhagen
Taste, Altered
Interaction of Inflammation, Taste Perception and Preferences As a Function of Physical Activity and Body Composition
The aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity.
- Trial name
- NCT06384365
- Testing
- Physical activity
- Where
- Austria
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Diet, Healthy, Obesity
Olfactory and Taste Changes During Fasting Mimicking Diet (FMD)
Literature experiences demonstrated the impact of medically-assisted pulsed fasting on olfactory behavior in both the animal and human models and - conversely - the lack of homogeneous results linked - up to now - to…
- Conditions
- Diet, Healthy, Obesity, Olfaction Disorders
- Trial name
- FMD1 (NCT04529161)
- Testing
- Fasting Mimicking Diet (FMD), Routinary diet habits
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Uniter Onlus
Multiple Myeloma
LI-TASTE Study: Light for Taste
Rationale: In 2020, 115,000 Dutch patients were diagnosed with cancer. Up to 85% of patients treated with radiotherapy involving the head and neck, chemotherapy or stem-celltransplantation (SCT) suffer from taste disorders…
- Trial name
- LI-TASTE (NCT06258096)
- Testing
- LX2.3 Laser and LED Photobiomodulation System
- Volunteers
- 52 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Taste, Altered
Fatty Acid Taste Rating With or Without Sour Taste Adaptation
We are trying to figure out whether the fatty acid taste is differentiated from sour taste.
- Trial name
- NCT04248374
- Testing
- Taste Intensity
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Purdue University
Genetics, Taste, Altered
Genetics of Bitter and Fat Taste
Obesity is an increasing problem for adults in the UK. Diets high in fat and sugar are the major contributors to weight gain. Individual differences in taste perception are a crucial factor in determining the investigator's…
- Conditions
- Genetics, Taste, Altered, Diet Habit, Obesity
- Trial name
- NCT04038281
- Testing
- Sensory tests
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Taste Alterations, Smell Disorder
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents
Childhood cancer is a serious and life-changing disease that affects thousands of children every year worldwide. In addition to the disease itself, cancer treatments such as chemotherapy often cause difficult side effects.
- Conditions
- Taste Alterations, Smell Disorder, Eating Behavior Changes
- Trial name
- QUALISENS (NCT07490093)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Leon Berard
Epilepsy
An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Nasal Spray.
This study will assess long-term safety and tolerability of repeat dose diazepam nasal spray in adolescents and adults with cluster seizures, with a focus on potential local effects (changes in nasal mucosa, olfaction, and taste).
- Trial name
- NCT02316847
- Testing
- diazepam nasal spray
- Where
- 33 sites in United States
- Volunteers
- 126 people
- Sponsor
- Acorda Therapeutics