Clinical trials: Altitude Hypoxia
Pulmonary Hypertension
Acute Excposure of High Altitude on ECG and Non-invasive Blood Pressure.
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response of High Altitude (Säntis, 2500m above sea level) on ECG repolarizations and non-invasive blood pressure measurements by…
- Trial name
- NCT03593083
- Testing
- Low altitude: 470m above sea level, Säntis; 2500m above sea Level
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Hypoxia, Altitude, Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Altitude, Hypoxia, Normobaric Hypoxia, Right Ventricular Function
- Trial name
- RIVER-Asthma (NCT07431580)
- Testing
- Normobaric Hypoxia
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Mona Lichtblau
High Altitude Headache
Intracranial Pressure in Experimental Models of Headache
The purpose of this study is to determine whether increased pressure in the head is elevated in people who suffer from High Altitude Headache.
- Trial name
- NCT01288781
- Testing
- Acetazolamide, Lactose monohydrate
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Hypoxia, Altitude
Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.
Hypoxic Challenge Testing (HCT) is the recommended method for inflight hypoxia risk assessment. Onboard oxygen administration remains controversial.
- Trial name
- NCT03976986
- Testing
- continuous-flow portable oxygen concentrator (cPOC), pulsed-flow portable oxygen concentrator (pPOC)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Son Espases
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Cystic Fibrosis
Pre-flight Evaluation of Adult Patients With Cystic Fibrosis
The purpose of the study is to investigate the relationship between hypoxemia achieved during Hypoxia Altitude Simulation test and sea level values of pulmonary function, arterial blood gases, pulse oximetry and cardiopulmonary…
- Trial name
- NCT01569880
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Hypoxia, Altitude, Cold Exposure
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the…
- Conditions
- Hypoxia, Altitude, Cold Exposure, Heat Exposure
- Trial name
- NCT06159374
- Testing
- exercise and environmental conditions
- Where
- Poland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
High Altitude Pulmonary Hypertension, Sleep Apnea
Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary…
- Trial name
- NCT01621061
- Where
- Kyrgyzstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep-related Respiratory Disturbance
Effects of Mild Hypobaric Hypoxia on Oxygen Saturation During Sleep
Ascent to altitude lowers oxygen saturation. In addition, sleep lowers oxygen saturation at any altitude. In a prior study, we observed that sleep at 8000 feet resulted in pronounced reduction in oxygen saturation, but did not…
- Trial name
- NCT00659009
- Testing
- Reduced barometric pressure, Sea level equivalent barometric pressure
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Boeing Company
Iron-deficiency, Ventricular Function
Iron Status and Cardiopulmonary Physiology
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
- Conditions
- Iron-deficiency, Ventricular Function, Pulmonary Vascular Resistance Abnormality, Altitude Hypoxia
- Trial name
- NCT03707249
- Testing
- Ferric Carboxymaltose Injectable Product, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
Altitude Hypoxia, Perfusion; Complications
The Pre-acclimatization Augmented Extreme Altitude Expedition
The aim of this study is to investigate the effect of pre-acclimatization in a nitrogen tent at home, ventilated with a slightly increased nitrogen percentage, in preparation for an expedition at extreme altitude.
- Trial name
- PRAGMAX (NCT05517044)
- Testing
- Nitrogen tent preacclimatization to high altitude
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altitude Sickness, Hypertension, Pulmonary
AZ, MZ, and the Pulmonary System Response to Hypoxia
The purpose of this proposal is to compare the physiological effects of acetazolamide (AZ) and methazolamide (MZ) on the control of breathing and hypoxic pulmonary vasoconstriction.
- Trial name
- NCT02760121
- Testing
- Acetazolamide, Methazolamide
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Altitude Hypoxia
The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks
The purpose of this study is to investigate which physiological process that controls normal human body homeostasis is affected by low levels of acute hypoxic exposure and whether there is a difference in those physiological…
- Trial name
- NCT05867719
- Testing
- Hypoxic breathing conditions
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Hypoxia, Altitude
Cocoa Flavanol Intake and Exercise in Hypoxia
Not uncommonly, sports events take place or finish at high altitude, where physical and cognitive (e.g. decision-making, motor control) performance in hypoxia is determining the outcome of sports performance.
- Trial name
- NCT03135314
- Testing
- cocoa flavanol
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Hypobaric Hypoxia, Metabolomics
Oxidative Stress in Hypobaric Hypoxia
The trial investigates changes in metabolism during high altitude expedition up to 6865m. A mass-spectrometry based platform is used to detect different oxidative stress related metabolites.
- Conditions
- Hypobaric Hypoxia, Metabolomics, Oxidative Stress, Acute Mountain Sickness
- Trial name
- NCT01436383
- Testing
- Hypoxic exposure
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern