Clinical trials: Altitude Hypoxia
ARDS, Hypoxia, Altitude
Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome
The purpose of this piece of research is to assess the effect of altitude on the clinical evolution of ARDS. For this purpose, patients who live and receive care at sea level are compared with those who live and receive care at…
- Conditions
- ARDS, Hypoxia, Altitude, Altitude Sickness/Epidemiology
- Trial name
- NCT02871063
- Volunteers
- 170 people
- Sponsor
- Guillermo Ortiz Ruiz
Hypoxia
Intravenous Iron Effects on Performance at High Altitude
To compare the effects of IV iron versus placebo (saline) injection on arterial oxygen saturation, submaximal exercise responses, and 2-mile treadmill time-trial performance during acute exposure to hypobaric hypoxia (430 mmHg…
- Trial name
- NCT06686693
- Testing
- Injectafer
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Pulmonary Hypertension
Acute Exposure to High Altitude on Symptoms
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in altitude related symptoms
- Trial name
- NCT03593005
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Pulmonary Edema
Pulmonary Function at High-Altitude
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE).
- Trial name
- NCT00604227
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Diabetes
Altitude, Exercise and Glucose Metabolism in Pre-diabetic Men
Concentric (CE) and eccentric (EE) exercises may differently affect glucose metabolism which may be additionally modified when exercises are performed in hypoxia, e.g.
- Trial name
- NCT01890876
- Testing
- Walking uphill, Walking downhill
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Universitaet Innsbruck
Altitude Edema
Advair HFA in Healthy and HAPE Predisposed Subjects
The current protocol is composed of two studies. The first study is designed to carefully evaluate the safety of high-dose salmeterol/fluticasone (Advair HFA) versus placebo (hydrofluoroalkane, HFA) administration over 7 days, as…
- Trial name
- SWIFTARC (NCT06040268)
- Testing
- Advair HFA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypobaric Hypoxia, Hypobaric Normoxia
Cognition at Altitude in HEMS - Part II
The aim of the current study is to evaluate under blinded conditions, both in a simulated environment and during helicopter flight, the effect of a rapid (within 20 minutes) exposure to altitude (4000 m asl) on physiological…
- Conditions
- Hypobaric Hypoxia, Hypobaric Normoxia, Cognitive Performance, Emergency Medicine
- Trial name
- HEMS II (NCT05073406)
- Testing
- Altitude exposure in hypobaric normoxic condition, Altitude exposure in hypobaric hypoxic condition
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Hypoxia
Effect of Short-term Simulated Altitude Exposure on Cardiopulmonary Functional Capacity
To determine if exposure of older volunteers, age 50-70y, who are healthy, but not physically active, to 7 days of mild hypoxia (15% oxygen, equivalent 2440m) will improve cardiopulmonary functional capacity.
- Trial name
- NCT02523716
- Testing
- Hypoxia, Normoxia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Healthy
Biovitals Analytics Engine - Altitude Study
Unexpected adverse health events resulting in a hospital admission can be potentially avoided by leveraging novel physiological sensors combined with advanced computational techniques to predict changes in physiology prior to the…
- Trial name
- NCT03661606
- Testing
- Simulated Altitude Chamber
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Biofourmis Singapore Pte Ltd.
High Altitude Pulmonary Hypertension, Sleep Apnea
HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT06489730
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Sleep
Nocturnal Oxygenation and Sleep-related Breathing Disorders During the First Night of a Stay at 2500m of High Altitude in Patients With Precapillary Pulmonary Hypertension
The impact of hypoxia at 2500m of high altitude on sleep in patients with precapillary pulmonary hypertension
- Trial name
- NCT05089487
- Testing
- Nocturnal rest (sleep study)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Altitude Hypoxia, Perfusion; Complications
The Pre-acclimatization Augmented Extreme Altitude Expedition
The aim of this study is to investigate the effect of pre-acclimatization in a nitrogen tent at home, ventilated with a slightly increased nitrogen percentage, in preparation for an expedition at extreme altitude.
- Trial name
- PRAGMAX (NCT05517044)
- Testing
- Nitrogen tent preacclimatization to high altitude
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neuromuscular Diseases, High Altitude Hypoxia
Assessing Air Travel Safety in Neuromuscular Dystrophy: Standard Versus Prolonged High Altitude Simulation Tests
To determine if a prolonged high altitude simulation test (HAST) lasting two hours, identifies more patients at risk of respiratory failure than the standard HAST lasting 20 minutes, in patients with neuromuscular disease (NMD)…
- Trial name
- NCT03312361
- Testing
- 15% oxygen
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- The Hospital for Sick Children
Altitude Intolerance, High-Altitude Illness
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex.
- Trial name
- NCT00202683
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Société Française de Cardiologie
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pulmonary Hypertension
Acute Exposure to Simulated Hypoxia on Exercise Capacity
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) in constant loaded exercise capacity.
- Trial name
- NCT03592927
- Testing
- Simulated Altitude (FiO2: 15.1%)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Healthy
Identifying Biological Markers for Altitude Exposure and Use of Recombinant Human Erythropoietin (rHuEPO)
The project represents a well powered study of the human response to altitude exposure combined with rHuEPO treatment. A total of 20 male and 20 female non-competing athletes will participate.
- Trial name
- NCT04227665
- Testing
- Sea level, Altitude
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cystic Fibrosis
Pre-flight Evaluation of Adult Patients With Cystic Fibrosis
The purpose of the study is to investigate the relationship between hypoxemia achieved during Hypoxia Altitude Simulation test and sea level values of pulmonary function, arterial blood gases, pulse oximetry and cardiopulmonary…
- Trial name
- NCT01569880
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Body Temperature Changes, Heat Stress
Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07664462
- Testing
- Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Ottawa
High Altitude Pulmonary Hypertension
Right Ventricular Function During Exercise in Highlanders/Lowlanders
The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by…
- Trial name
- NCT03165032
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich