Clinical trials: Altitude Hypoxia
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude Pulmonary Hypertension, Sleep Apnea
Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT03165019
- Where
- Kyrgyzstan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Right Ventricular Function During Exercise in Highlanders/Lowlanders
The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by…
- Trial name
- NCT03165032
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Right Ventricular Function at Rest in Highlanders/Lowlanders
The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.
- Trial name
- NCT03165656
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Cerebral Tissue Oxygenation in Highlanders/Lowlanders
The purpose of the current study is to evaluate the cerebral tissue oxygenation of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT03172429
- Where
- Kyrgyzstan
- Volunteers
- 79 people
- Sponsor
- University of Zurich
Intermittent Hypoxia
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Trial name
- NCT03588676
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Robert L. Owens
Hypoxia, Altitude
Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.
Hypoxic Challenge Testing (HCT) is the recommended method for inflight hypoxia risk assessment. Onboard oxygen administration remains controversial.
- Trial name
- NCT03976986
- Testing
- continuous-flow portable oxygen concentrator (cPOC), pulsed-flow portable oxygen concentrator (pPOC)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Son Espases
Altitude Hypoxia, Ventilation
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Conditions
- Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress
- Trial name
- NCT03368352
- Testing
- Melatonin, Hypoxia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Effects of High Altitude
Acclimatization of Healthy Subjects During a Stay at 3200 m
The study evaluates respiratory acclimatization in healthy lowlanders staying for 3 weeks at 3200 m.
- Trial name
- NCT02451020
- Testing
- Altitude exposure
- Where
- Kyrgyzstan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Iron-deficiency, Ventricular Function
Iron Status and Cardiopulmonary Physiology
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
- Conditions
- Iron-deficiency, Ventricular Function, Pulmonary Vascular Resistance Abnormality, Altitude Hypoxia
- Trial name
- NCT03707249
- Testing
- Ferric Carboxymaltose Injectable Product, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
Altitude, Hypoxia
Endurance Performance at Altitude
The degree to which endurance exercise performance is diminished in acute hypoxia is variable and appears to be the result of several different physiological processes, however this research focuses on hypoxic pulmonary…
- Conditions
- Altitude, Hypoxia, Sildenafil, Exercise
- Trial name
- NCT03710369
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypoxia, Altitude, Brain
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not…
- Trial name
- NCT03541993
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
ARDS, Hypoxia, Altitude
Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome
The purpose of this piece of research is to assess the effect of altitude on the clinical evolution of ARDS. For this purpose, patients who live and receive care at sea level are compared with those who live and receive care at…
- Conditions
- ARDS, Hypoxia, Altitude, Altitude Sickness/Epidemiology
- Trial name
- NCT02871063
- Volunteers
- 170 people
- Sponsor
- Guillermo Ortiz Ruiz
Hypoxia, Altitude
Cocoa Flavanol Intake and Exercise in Hypoxia
Not uncommonly, sports events take place or finish at high altitude, where physical and cognitive (e.g. decision-making, motor control) performance in hypoxia is determining the outcome of sports performance.
- Trial name
- NCT03135314
- Testing
- cocoa flavanol
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Hypertension, Pulmonary
Study of the Effects of Iron on Lung Blood Pressure at High Altitude
Body iron levels may be important in determining how the blood pressure in the lungs changes in response to low oxygen levels. At high altitude, where oxygen levels are low, some patients develop elevated lung blood pressure.
- Trial name
- NCT00960921
- Testing
- Iron sucrose, Normal saline
- Where
- Kyrgyzstan
- Sponsor
- University of Oxford
Hypoxia
MEDEX Hidden Valley 2008
During a multi-week expedition to the Himalaya, we aim to investigate i) whether dietary supplementation with carbohydrate drinks and gels can improve physical performance; and ii) the underlying mechanisms for any observed…
- Trial name
- NCT00731510
- Testing
- Carbohydrate energy drink, Aspartame
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical Expeditions Ltd
Acute Mountain Sickness
Inhaled Budesonide and Acute Mountain Sickness
The primary objective of the study is to investigate the effect of inhaled budesonide on the incidence of AMS. The primary study question to ask is: 1.
- Trial name
- NCT02811016
- Testing
- Budesonide 200, Budesonide 800
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Hypoxia, Altitude Sickness
Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely
This project will consist of two studies, each investigating resting and exercise cardio-respiratory responses during exposure to hypoxia in individuals born prematurely and individuals born at full term of two different age…
- Conditions
- Hypoxia, Altitude Sickness, Tolerance
- Trial name
- PreTerm (NCT02780908)
- Testing
- Graded exercise testing, Resting testing
- Where
- 2 sites in Slovenia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Altitude, Hypoxia
Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance
Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep.
- Conditions
- Altitude, Hypoxia, Environmental Sleep Disorder
- Trial name
- NCT00498563
- Testing
- altitude exposure in hypobaric chamber
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Acute Mountain Sickness
Acclimatization Mechanisms During Ascent to 7500m
The trial evaluates the role of ascent protocol on acute mountain sickness and cardio-respiratory physiology during an ascent to Muztagh Ata (7546m).
- Trial name
- NCT00603122
- Testing
- ascent protocol
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Zurich