Clinical trials: Altitude Sickness
Hypoxia, Altitude Hypoxia
The Psychophysiological Effect of Simulated and Terrestrial Altitude
The aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.
- Conditions
- Hypoxia, Altitude Hypoxia, Altitude Sickness, Altitude
- Trial name
- Hypoxia (NCT04075565)
- Testing
- Terrestrial altitude, Cloud 9
- Where
- 3 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Pregnancy, IUGR
Effects of High Altitude on AMPK Activation
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE).
- Conditions
- Pregnancy, IUGR, Preeclampsia
- Trial name
- NCT02391519
- Testing
- Collection of myometrial, cord blood, and placental tissue samples
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypothermia, Hypoxia
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
Warfighter Performance Optimization in Extreme Environments remains an area of important and intense investigation, with the following goals: (1) Optimize, sustain and augment medical readiness and physiological/ psychological…
- Conditions
- Hypothermia, Hypoxia, Mountain Sickness
- Trial name
- PhITHy-Ho (NCT06129825)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), 6MWT Assessed at High Altitude (3200m) vs Low Altitude (760m)
To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD)
- Trial name
- NCT06489691
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), SDB Assessed at HA (3200 m) vs LA (760 m)
To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live >2500m on sleep disordered breathing
- Trial name
- NCT06489717
- Testing
- SDB assessment
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP)
- Trial name
- NCT06489704
- Testing
- Echocardiography
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Highlanders With High Altitude Pulmonary Hypertension (HAPH), 6 Minute Walk Distance (6MWD) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD) assessed at 3200m.
- Trial name
- NCT06489743
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Hypoxia, Mental Disorder
Going to Altitude With Anxious-depressive Symptoms
Introduction: Currently, there is a lack of international guidelines or clinical recommendations for individuals with mental illnesses (i.e., bipolar disorder, posttraumatic stress disorder) going on high altitude sojourns.
- Trial name
- Psychoxie (NCT05323864)
- Testing
- Hypoxia
- Where
- Austria
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitaet Innsbruck
High Altitude Pulmonary Hypertension
Highlanders With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Arterial Pressure (PAP) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on pulmonary arterial pressure (PAP) assessed at 3200 m.
- Trial name
- NCT06489756
- Testing
- Echocardiography
- Where
- Kyrgyzstan
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Altitude Edema
Advair HFA in Healthy and HAPE Predisposed Subjects
The current protocol is composed of two studies. The first study is designed to carefully evaluate the safety of high-dose salmeterol/fluticasone (Advair HFA) versus placebo (hydrofluoroalkane, HFA) administration over 7 days, as…
- Trial name
- SWIFTARC (NCT06040268)
- Testing
- Advair HFA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Mountain Sickness (AMS)
Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness
This pilot study aims to evaluate the efficacy of positive expiratory pressure (PEP) therapy at 10 cmH₂O in improving peripheral oxygen saturation (SpO₂) and mitigating symptoms of acute mountain sickness (AMS) in healthy…
- Trial name
- NCT07148674
- Testing
- Positive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- BiALP - Alpine, Disaster and Wilderness Medicine
Acute Mountain Sickness
Voluntary Isocapnic Hyperpnea in Hypoxia to Mitigate Acute Mountain Sickness
This study investigates the effects of a brief Voluntary Isocapnic Hyperpnoea (VIH) on Acute Mountain Sickness (AMS) symptoms, SpO₂, blood pressure, and blood gas homeostasis in normobaric hypoxia, to evaluate whether such…
- Trial name
- NCT07126834
- Testing
- VIH
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Sport - National Research Institute, Poland
High Altitude Effects, High Altitude Hypoxia
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
Each year, millions of people living at low altitude (< 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities.
- Conditions
- High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS), Plasma Volume
- Trial name
- NCT07118462
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Hypoxia, Altitude
Treatment of Chronic Mountain Sickness
This study aims to assess the effect of two drugs for the treatment of chronic mountain sickness in highlanders.
- Trial name
- Exp5300 (NCT04251364)
- Testing
- Acetazolamide, Atorvastatin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Negative Air Ions, Altitude Sickness
The Effects of Artificial Air Negative Ions on High-Altitude Acclimatization, Serum HIF1, and PWC170 Index
To explore the effects of negative ions generated by an ion converter on the high-altitude acclimatization of healthy populations and their impact on serum HIF1 (hypoxia-inducible factor 1) and PWC170 index after entering…
- Conditions
- Negative Air Ions, Altitude Sickness, High-altitude Adaptation
- Trial name
- 2022JW (NCT07056751)
- Testing
- Air negative ion intervention study, No air negative ion intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Putian City, Putian, Fujian
Extracorporeal Membrane Oxygenation, Membrane Lung Function
Evaluation of Membrane Lung Function in High-altitude Regions
Over the last 20 years, extracorporeal membrane oxygenation (ECMO) has been used to support adult patients with respiratory or cardiac failure who are unlikely to survive conventional treatment methods.
- Conditions
- Extracorporeal Membrane Oxygenation, Membrane Lung Function, High Altitude
- Trial name
- NCT06152744
- Testing
- Monitoring membrane lung function at different altitudes
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Chao Yang Hospital
Hypoxia, Altitude Sickness
Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement
The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm…
- Trial name
- NCT07018817
- Testing
- motor execution motor imagery
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
High Altitude
The Study of Personalized Health Check-up Programs and Standards for High-altitude Migrant Populations
By using wearable devices to monitor and record the physiological data changes and health outcomes (incidence and severity of high-altitude illnesses) of high-altitude migrants at different stages (pre-entry, acute/chronic…
- Trial name
- NCT07018193
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
High Altitude
High Altitude Muscle Recovery
To understand alterations in glycogen and molecular regulation of skeletal muscle glucose uptake, glycogen synthesis, and muscle protein recovery when consuming CHO (glucose) or CHO+PRO (glucose + whey) post-exercise during…
- Trial name
- HAMR (NCT06392373)
- Testing
- CHO+PRO, CHO
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine