Clinical trials: Alveolar Hypoventilation
Obesity Hypoventilation Syndrome
Prevalence Rate, and Clinical Characteristics of Obesity Hypoventilation Syndrome Via Screening Patients Admitted to Medical Intensive Care Units
A prospective observation study to screen adult obese (BMI ≥30 kg/m2) patients who were newly admitted to the medical intensive care units and turned out to be diagnosed as Obesity hypoventilation syndrome(OHS).
- Trial name
- NCT02934581
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Distress Syndrome, Shock
Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
The objective of our study is to evaluate the efficacy of helmet ventilation as compared with Face mask in patients with respiratory failure.
- Conditions
- Acute Respiratory Distress Syndrome, Shock, Ventilatory Failure, Cardiogenic Pulmonary Edema
- Trial name
- NCT01680783
- Testing
- Non invasive ventilation using a helmet hyperbaric device, Noninvasive ventilation via facemask
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Chicago
Hypertension
Sympathetic and Blood Pressure Responses to Aerobic Exercise and Guided Respiration in Hypertensives
Hypertension is serious health problem in Brazil and affects almost 30%of adult population. It is known that there are pharmacologic and nonpharmacologic strategies for treating hypertension.
- Trial name
- NCT02608827
- Testing
- Resperate®-InterCure Ltda, Music group (GC)
- Volunteers
- 29 people
- Sponsor
- University of Sao Paulo General Hospital
Hypoventilation
Positive Pressure and Gravity Affect Volumetric Capnography
Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body…
- Trial name
- NCT03853057
- Testing
- body positions
- Where
- Argentina
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
COPD, Severe Early-Onset, Ventilatory Failure
Customized Masks in Non-Invasive Mechanical Ventilation
In non-invasive mechanical ventilation (NIMV), the interface is the primary determinant of success, as adherence and quality of therapy mainly depend on it.
- Conditions
- COPD, Severe Early-Onset, Ventilatory Failure, Als, Non Invasive Ventilation
- Trial name
- NCT06215391
- Testing
- 3d printed mask
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario 12 de Octubre
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure
To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Neuromuscular Diseases, Ventilatory Failure
- Trial name
- CRF-QoL (NCT04236726)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Congenital Central Hypoventilation Syndrome, Patients With Nocturnal Ventilatory Assistance
Evaluation of the Awakening Capability by a Vibrating Bracelet (BRASSARD)
As part of developing a relay alarm project, the aim of the study is to test a sleeper's capability to wake up via a vibrating alarm around the wrist (vibrating bracelet).
- Conditions
- Congenital Central Hypoventilation Syndrome, Patients With Nocturnal Ventilatory Assistance, Healthy Volunteers
- Trial name
- BRASSARD (NCT03053011)
- Testing
- Vibrating bracelet
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Fibromyalgia, Fibromyalgia Syndrome
Slow Breathing and Resistance Exercise in Fibromyalgia
This randomized controlled trial investigates whether slow breathing techniques influence heart rate variability, exercise self-efficacy, and resistance exercise performance in women with fibromyalgia.
- Trial name
- Breath-fibro (NCT07404384)
- Testing
- Slow Breathing with Visual Pacer, Slow Breathing without Visual Pacer, Spontaneous Breathing (Active Control)
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- University of Malaga
Respiratory Insufficiency, Obesity Hypoventilation Syndrome
Juno Perth Clinical Trial
This study is to evaluate the efficacy of a new therapy (Automatic Expiratory Positive Airway Pressure with intelligent Volume Assured Pressure Support (AutoEPAP iVAPS)) designed to treat respiratory insufficiency, respiratory…
- Conditions
- Respiratory Insufficiency, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Disease
- Trial name
- NCT02317042
- Testing
- Juno
- Where
- 2 sites in Australia
- Volunteers
- 25 people
- Sponsor
- ResMed
Hypercarbia
The Effect of Ketamine in the Prevention of Hypoventilation in Patients Undergoing Deep Sedation Using Propofol and Fentanyl
Procedures performed under sedation have the same severity in regards to morbidity and mortality as procedures performed under general anesthesia1.
- Trial name
- NCT01825083
- Testing
- Ketamine
- Where
- United States
- Sponsor
- Northwestern University
One-Lung Ventilation, Thoracic Surgery
Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups.
- Trial name
- NCT06505772
- Testing
- Dexmedetomidine, Normal saline
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus University
End of Life, Respiratory Failure
Feasibility of the Comfort Measures Only Time Out (CMOT)
Nearly 25% of Americans die in intensive care units (ICUs). Most deaths in ICUs are expected and involve the removal of ventilator support, or palliative withdrawal of mechanical ventilation (WMV).
- Conditions
- End of Life, Respiratory Failure, Ventilatory Failure, Coma
- Trial name
- NCT05861323
- Testing
- Comfort Measures Only Time out (CMOT)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Beth Israel Deaconess Medical Center
Congenital Central Hypoventilation Syndrome (CCHS)
Identifying Biomarkers & Dysregulated Biological Pathways in Blood and Urine of Congenital Central Hypoventilation Syndrome (CCHS) Patients
The CCHS study is a prospective, open-label, monocentric, interventional study with diagnostic and prognostic objectives, conducted in two phases.
- Trial name
- CCHSBiomarkers (NCT06997146)
- Testing
- Blood and Urine Sampling, Polysomnography, lung function tests
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoventilation
CPAP and Lateral Neck Rotation on Anesthetized Children
The primary aim of this study is to determine the changes in upper airway anatomy that occur during lateral neck rotation and subsequent administration of continuous positive airway pressure (CPAP) in anesthetized, spontaneously…
- Trial name
- NCT00592423
- Testing
- Continuous Positive Airway Pressure during MRI
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity Hypoventilation Syndrome
Obesity Hypoventilation Syndrome Prevalence Study
This is an observational study to characterize the prevalence of Obesity Hypoventilation Syndrome in patients referred to the sleep lab.
- Trial name
- NCT01964339
- Testing
- BMI greater than or equal to 30kg/m2 scheduled for PSG. Undergo blood draw (venous blood gas and metabolic panel) and data collection from PSG study., BMI greater than or equal to 30kg/m2 scheduled for PSG. Undergo blood draw (arterial blood gas and metabolic panel) and data collection from PSG study.
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Philips Respironics
Obesity Hypoventilation Syndrome
PAP Therapy in Patients With Obesity Hypoventilation Syndrome
The role of different levels of compliance and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depression and death rate in patients with obesity hypoventilation syndrome…
- Trial name
- NCT03449641
- Testing
- Positive airway pressure (PAP)
- Volunteers
- 252 people
- Sponsor
- University of Crete
Hypertension
Comparison of Breathing Exercise for Hypertensive Patients
To determine the Effectiveness of diaphragmatic breathing vs. slow breathing techniques on blood pressure and Quality of life in adults with stage 1 hypertension.
- Trial name
- NCT05158569
- Testing
- Slow breathing exercise group, Diaphragmatic breathing exercise group
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Obesity Hypoventilation Syndrome
A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)
Obesity is an escalating problem in the UK and a proportion of these patients have a condition known as Obesity Hypoventilation Syndrome (OHS).
- Trial name
- NCT01483716
- Testing
- Rehabilitation
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity Hypoventilation Syndrome (OHS)
HVNI Versus NIV In Management Of Acute Hypercapnic Respiratory Failure In OHS
1. Assessment of benefits of HVNI in management of obesity hypoventilation syndrome complicated with acute hypercapnic respiratory failure. 2.
- Trial name
- NCT05805293
- Testing
- High-Velocity Nasal Insufflation Therapy, Non-Invasive Ventilation
- Volunteers
- 56 people
- Sponsor
- Assiut University
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Patient -Ventilator Interaction in Chronic Respiratory Failure
To evaluate a novel advanced physiological monitoring system to improve nocturnal non-invasive ventilation (NIV) in Neuromuscular disease (NMD), Chest wall disease (CWD), Chronic Obstructive Pulmonary Disease (COPD) and Obesity…
- Conditions
- Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome, Neuromuscular Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01371149
- Testing
- Surface parasternal electromyography (EMG) set up
- Where
- 2 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- Michelle Ramsay