Clinical trials: Alzheimer' Disease
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer Disease, Mild Cognitive Impairment
Phenserine on the Alzheimer's Treatment Horizon, Study 1
The goal of this clinical trial is to evaluate if phenserine can treat early or mild Alzheimer's Disease (AD) by comparing it to donepezil.
- Trial name
- PATH-1 (NCT06774261)
- Testing
- Phenserine, Donepezil (Aricept®)
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Helse Stavanger HF
Alzheimer Disease and Related Dementias
Designing Care Management for Hospice Transitions for Persons Living With Advanced Dementia
This study will test a care management intervention to guide end-of-life care and hospice transitions for persons with dementia and their care partners receiving home healthcare and ascertain feasibility, acceptability, fidelity…
- Trial name
- ENGAGE-D (NCT07182357)
- Testing
- Dementia Care Management Checklist for Hospice Transitions
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- New York University
Alzheimer Disease, Positron Emission Tomography
Establishment of the Chinese Preclinical Alzheimer's Disease Study With Multiple Neuroimaging
The goal of this observational study is to investigate neuroimage and biomarkers in the Alzheimer's continuum in Chinese population.
- Trial name
- NCT06827678
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Alzheimer&Amp;Amp;#39;s Disease, Alzheimer Disease
Large-coil Parietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Alzheimer Disease (AD)
The goal of this clinical trial is to learn if using large-coil (or "deep") repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus and surrounding areas is feasible, tolerable, and potentially efficacious for…
- Conditions
- Alzheimer&Amp;Amp;#39;s Disease, Alzheimer Disease, Dementia Alzheimer Type, Mild Alzheimer&Amp;Amp;#39;s Disease
- Trial name
- PROMIS-AD (NCT06597942)
- Testing
- TMS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD)
Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study
Recent studies have identified an association between Alzheimer's Disease (AD) and an expansion of DNA content in the brain (prefrontal cortex).
- Trial name
- SONATAS (NCT07210528)
- Testing
- Emtricitabine (FTC), Descovy® (TAF/FTC)
- Where
- Singapore
- Volunteers
- 48 people
- Sponsor
- National University Hospital, Singapore
Alzheimer Disease
Wearables-and Blood-based Biomarkers-incorporated Modernisation of Circadian Rhythm Disruption Management in People Living With Alzheimer's Dementia: A Stepwise Study From Digital Inclusivity, Digital Therapy, to Digital Phenotyping and Biomarker Exploration
By 2025, Taiwan will become a super-aged society, with the number of Alzheimer's disease patients continuing to rise. However, the vast majority of dementia patients experience "behavioral and psychological symptoms of dementia"…
- Trial name
- NCT07222449
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
Mild Cognitive Impairment (MCI), Mild Dementia
Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease
A randomized, double-blind, placebo-controlled, dose-finding Phase 2a clinical trial will be conducted to evaluate the efficacy and safety of KDS2010 in patients with Mild Cognitive Impairment (MCI) due to Alzheimer's disease…
- Conditions
- Mild Cognitive Impairment (MCI), Mild Dementia, Alzheimer's Disease
- Trial name
- NCT07027072
- Testing
- KDS2010
- Where
- 8 sites in South Korea
- Volunteers
- 114 people
- Sponsor
- NeuroBiogen Co., Ltd
Alzheimer's Disease (AD)
VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in Participants With Early Alzheimer's Disease
This study is to be conducted in participants with early Alzheimer's Disease to test VY7523, a new drug being researched for treatment of Alzheimer's Disease.
- Trial name
- NCT06874621
- Testing
- VY7523
- Where
- 23 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- Voyager Therapeutics
Alzheimer's Disease (AD)
Radiolabeled TSPO Targeted Molecular Probe in Alzheimer's Disease.
Evaluate the clinical application value of the novel radiolabeled TSPO-targeted molecular probe Gallium [68Ga]-DOTA-HK-011 in neuroinflammation imaging of Alzheimer's disease.
- Trial name
- NCT07105956
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Mild Cognitive Impairment, Alzheimer's Disease
A Double-Blind, Placebo-Controlled, Dose Ranging Study of Xanamem® in Healthy Elderly Volunteers
Xanamem® is being developed as a potential drug for Mild Cognitive Impairment in Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain.
- Trial name
- XanaMIA-DR (NCT04983368)
- Testing
- Xanamem® 5 mg, Xanamem® 10 mg
- Where
- 5 sites in Australia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease
TMS for Cognitive Decline in Aging and Preclinical AD
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical…
- Conditions
- Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
- Trial name
- NCT06956300
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Caregivers of Alzheimer's Disease or Memory Problem Patients, Caregiver Wellbeing
Risk Screening & Primary Prevention of Elder Abuse in People Living With Dementia
The goal of this clinical trial is to test a risk assessment screening and intervention for caregivers of people with dementia. The main questions it aims to answer are: 1.
- Conditions
- Caregivers of Alzheimer's Disease or Memory Problem Patients, Caregiver Wellbeing, Elder Abuse
- Trial name
- WECARE (NCT07429591)
- Testing
- Risk Assessment Screening, Coach and Website Intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Southern California
Drug Drug Interaction (DDI)
A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates
The goal of this study is to learn if the investigational drug, BMS-984923 will impact the exposure and clearance of other medications when given together.
- Trial name
- NCT06632990
- Testing
- BMS-984923, Midazolam, Caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Allyx Therapeutics
Alzheimer Disease, Dementia Alzheimer Type
Cervical Lymphatico-Venous Bypass for Treatment of Alzheimer's Disease - Proof of Concept Study (CLyVeB-AD-1 Study)
Alzheimer's disease (AD), one of the most common causes of dementia in Singapore and the developed world, is a neurodegenerative disorder with high socioeconomic impact. Accumulation of neurotoxic proteins (ie.
- Conditions
- Alzheimer Disease, Dementia Alzheimer Type, Dementia Alzheimer's Type, Alzheimer's Disease
- Trial name
- CLyVeB-AD-1 (NCT06965062)
- Testing
- Deep cervical lymph node to venous bypass (DCLNV-BP)
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Vincent Tay Khwee Soon
Dementia, Physical Activity
Co-design and Pilot Study in VR-based Physical Activity and Cognitive Training
Physical activity and reminiscence therapy alone have been studied with no clear effectiveness in Alzheimer's disease, but their combined intervention remains unknown.
- Conditions
- Dementia, Physical Activity, Reminiscence Therapy, Co-design
- Trial name
- NCT06982170
- Testing
- A physical activity and reminiscence therapy
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Alzheimer&Amp;#39;s Disease (AD)
Clinical Study on Lymphaticovenous Anastomosis（LVA） for the Treatment of Alzheimer's Disease（AD）
The goal of this clinical trial is to explore the safety and efficacy of Lymphaticovenous Anastomosis (LVA) for the Treatment of Alzheimer's Disease (AD). The main questions it aims to answer are: 1.
- Trial name
- LVA; AD (NCT06918145)
- Testing
- Lymphaticovenous Anastomosis
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Alzheimer Disease, Alzheimer Disease With Delusions
Tau Networks in Psychotic Alzheimer's Disease
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology.
- Conditions
- Alzheimer Disease, Alzheimer Disease With Delusions, Alzheimer Disease With Psychosis
- Trial name
- NCT05847192
- Testing
- [18F]-PI2620 PET scan
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Alzheimer's Disease
Clinical Study on Deep Cervical Lymphatic Trunk Decompression Combined With Mid-Cervical Deep Lymph Node-External Jugular Vein Anastomosis for Alzheimer's Disease Treatment
The aim of this study is to evaluate the feasibility, safety, and efficacy of bilateral deep cervical lymphatic trunk decompression combined with mid and deep cervical lymph node-extracervical vein anastomosis in the treatment of…
- Trial name
- NCT06936514
- Testing
- Bilateral Cervical Deep Lymphatic Trunk Decompression Combined with Mid-Cervical Deep Lymph Node-External Jugular Vein Anastomosis for Alzheimer's Disease
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team