Clinical trials: Alzheimer's Disease - MCI
Alzheimer Disease, Mild Cognitive Impairment
COMMETS- Combination MCI Metabolic Syndrome
The investigators propose a proof of concept RCT (randomized clinical trial), testing the efficacy of intranasal insulin (INI) with semaglutide, a combination therapy with strong biological plausibility to benefit impaired…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Metabolic Syndrome
- Trial name
- NCT06072963
- Testing
- Semaglutide, Intranasal insulin
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Mild Cognitive Impairment
The Effect of a 36-week Tablet-based Intervention on Multiple Domains in Older Adults With Mild Cognitive Impairment
This is a pilot study to examine the feasibility of a formal 30-minute daily program on a tablet computer (simply a "tablet") in subjects with mild cognitive impairment (MCI).
- Trial name
- KodroSol (NCT02087618)
- Testing
- Kodro+, Kodro+D
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Alzheimer's Disease, Mild Cognitive Impairment
The Treatment of High Intensity Transcranial Current Stimulation for Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive dysfunction and behavioral impairment. It is currently the most common type of dementia in the old age.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06380725
- Testing
- Transcranial alternating current stimulation(real stimulation)
- Volunteers
- 60 people
- Sponsor
- Anhui Provincial Hospital
Alzheimer Disease
A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
The purpose of this study is to learn more about the safety, effectiveness and tolerability of the study drug called Benfotiamine which may delay or slow the progression of the symptoms of early Alzheimer's disease.
- Trial name
- NCT06223360
- Testing
- Low Dose Benfotiamine, High Dose Benfotiamine
- Where
- 47 sites in United States
- Volunteers
- 406 people
- Sponsor
- Weill Medical College of Cornell University
Mild Cognitive Impairment, Dementia
Implications for Management of PET Amyloid Classification Technology in the Imaging Dementia(IDEAS) Trial
The main purpose of this study is to build upon the evidence captured in the Imaging Dementia - Evidence for Amyloid Scanning (IDEAS; NCT02420756) trial to include valuable information regarding patient-reported outcomes and…
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer's Disease
- Trial name
- IMPACT2 (NCT02781220)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Utah
Alzheimer Disease, Dementia
BarcelonaBeta Dementia Prevention Research Clinic: a Study on Risk Factors Disclosure
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03847038
- Testing
- Preventive strategies advice and dementia risk estimate disclosure
- Where
- Spain
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Alzheimer's Disease (AD)
Biomarkers in a Candian Memory Clinic
This is a prospective, observational, case control study in a real-world cohort of patients referred by a primary care physician to a tertiary memory clinic for cognitive concerns.
- Trial name
- BioMIND (NCT06843109)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild Cognitive Impairment
Platform-based Mild Cognitive Impairment (MCI) Trial
The process of receiving a diagnosis of mild cognitive impairment (MCI) is recognized to induce behavioral responses that can be either adaptive or maladaptive.
- Trial name
- NCT03987464
- Testing
- Planning for the Future, Enhanced Medical Engagement, Confidence Building and Social Engagement
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Allison Gibson
Polypharmacy, Alzheimer's Disease and Related Dementias
ALIGN: Aligning Medications With What Matters Most (Demonstration)
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners.
- Conditions
- Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
- Trial name
- NCT06335953
- Testing
- Pharmacist-led deprescribing intervention
- Where
- United States
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Dementia
Detecting Probable Alzheimer's Disease From Speech Using Linguistical Analysis
The object of this study is to investigate the use of linguistic deficits from speech samples for the early detection of Mild Cognitive Impairment and probable Alzheimer's disease.
- Trial name
- NCT04041895
- Testing
- Audio speech recording
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- East Tennessee State University
Mild Cognitive Impairment, Alzheimer Disease (AD)
Microbiome in Aging of Gut and Brain
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Trial name
- MiaGB (NCT07799402)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alzheimer or Mild Cognitive Impairment
ARIADE : Augmented Reality for Improving Autonomy in Dementia
Navigating according to a specific goal is a common activity of everyday life. Spatial navigation requires the implementation of motor and perceptual functions (sight, walking, proprioception), but also various cognitive…
- Trial name
- ARIADE (NCT04742465)
- Testing
- Augmented reality technological assistance for the movements of people with Alzheimer's disease or MCI in a controlled environment.
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Rennes University Hospital
Cognitive Dysfunction
Integrative Therapy for Holistic, Natural Cognition and Lifestyle Rehabilitation
An observational study to determine outcomes of older adults who are under naturopathic medical care for cognitive complaints at a specific clinic in Southern California.
- Trial name
- ITHNCLR (NCT04284449)
- Testing
- Whole-practice cognitive optimization
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Alzheimer Disease, Mild Cognitive Impairment
Orientation in AD Patients: PET-MR Study
Despite the high prevalence of Alzheimer's disease (AD), its underlying mechanisms remain poorly understood. An emerging body of evidence supports disorientation as an early marker for AD-related neurodegeneration.
- Trial name
- NCT03030365
- Testing
- Siemens "Biograph mMR" PET-MR (3T)
- Volunteers
- 30 people
- Sponsor
- Assuta Medical Center
Subjective Cognitive Decline, Alzheimer Dementia
Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults
In this study the investigators explore a pragmatic strategy to increase cognitive screening rates in the community. The investigators will compare the monetary value of different combinations of SCD questionnaires, digital…
- Trial name
- NCT06191952
- Testing
- Cognigram, Subjective cognitive decline questionnaire (SCD-Q), blood-based biomarkers
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Mild Cognitive Impairment, Mild Dementia
Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
This study is a multicentre, randomized, double-blind, controlled trial that aims to investigate the efficacy of multi-domain life-style intervention including low inflammatory-index diet, exercise, and cognitive training in…
- Trial name
- SIM-2 (NCT05887674)
- Testing
- Diet intervention, Exercise, Cognitive training
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
Dementia, Alzheimer Disease
A Longitudinal Multidimensional Population Study on Brain Aging
Longitudinal observational study of cognitive functions, physical health and biological parameters in the whole population living in Abbiategrasso born between 1935 and 1939,1773 subjects, followed for six years in order to know…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- InveCeAb (NCT01345110)
- Where
- Italy
- Volunteers
- 1,321 people
- Sponsor
- Fondazione Golgi Cenci
Alzheimer's Disease, Mild Cognitive Impairment
Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)
The main purpose of this study is to assess the ability of a repeated high-frequency site-based computerized cognitive assessment to evaluate the potential treatment effects of donepezil (MK-0000) compared with placebo among…
- Trial name
- NCT04730635
- Testing
- Donepezil
- Where
- 10 sites in United States, Australia
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC