Clinical trials: Alzheimer's Disease Prevention
Depression
Personalized Prevention of Depression in the Workplace (e-pD-Work)
The main goal is to design, develop and evaluate a personalized intervention to prevent depression in the workplace, based on Information and Communication Technologies (ICTs), predictive risk algorithms and decision support…
- Trial name
- e-pD-Work (NCT04858737)
- Testing
- e-predictD-Work intervention, Brief psychoeducational messages
- Where
- Spain
- Volunteers
- 1,054 people
- Sponsor
- The Mediterranean Institute for the Advance of Biotechnology and Health Research
Subjective Cognitive Decline (SCD)
Personalized Brain Health Service and Dementia Prevention
This study evaluates the feasibility of implementing a Brain Health Service (BHS) to assess and reduce dementia risk in individuals with Subjective Cognitive Decline (SCD).
- Trial name
- B-HEALTH (NCT07698431)
- Testing
- Multimodal Lifestyle Intervention, Lifestyle Recommendations and Counseling
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Alzheimer's Disease, Dementia
Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies
The Alzheimer's Prevention Registry (www.endALZnow.org) will collect contact and demographic information on individuals. The objective is to provide information the latest news and advances in Alzheimer's prevention research, and…
- Trial name
- APR (NCT02022943)
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Banner Health
Alzheimer Disease, Mild Cognitive Impairment
The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition
The PREVENTION Trial is a 12-month, two-arm randomized clinical trial (RCT) in adults 50-80 years old experiencing cognitive decline.
- Trial name
- PREVENTION (NCT04082611)
- Testing
- Data-Driven Clinical Recommendations, Coached Data-Driven Clinical Recommendations
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Saint John's Cancer Institute
Dementia, Alzheimer Type
Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"
The RAATE proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group.
- Trial name
- RAATE (NCT03890861)
- Testing
- Physical activity, Successful Aging
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer Disease
Epidemiology and Biomarker Study in Alzheimer's Disease
Study AACU determines rates of cognitive worsening in participants within elevated and not elevated plasma P-tau217 cohorts. Participation in AACU will last approximately 7 years.
- Trial name
- ANCHOR-AD (NCT07142954)
- Testing
- P-tau217 Test
- Where
- 4 sites in United States, Japan
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alzheimer Disease, Preclinical Alzheimer's Disease
AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)
This is a Phase 1, multicenter, randomized, double-blind, placebo-controlled, multiple-dose-escalation study evaluating the safety, tolerability, and immunogenicity of AV-1980R, an investigational vaccine targeting pathological…
- Trial name
- TAURUS-1980 (NCT07158905)
- Testing
- AV-1980R 20 µg, AV-1980R 60 µg, AV-1980R 180 µg
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Institute for Molecular Medicine
Alzheimer Disease (AD)
Daridorexant for Alzheimer Disease Prevention
This study will evaluate whether daridorexant, a DORA sleep medication, can support brain health by promoting the clearance of proteins linked to the development and progression of Alzheimer's disease.
- Trial name
- PAD-DORA (NCT07213349)
- Testing
- Daridorexant 50 mg
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Cognitive Impairment, Dementia
Randomized Trial of Exercise and Social Interaction in a Community-Based Sample of Non-Demented Chinese Elders
A pilot randomized clinical trial was conducted in a random sample of 120 non-demented Chinese elders (ages 60-79) living in a defined community in Shanghai, China to compare the effects of interventions (fast walking, Tai Chi…
- Conditions
- Cognitive Impairment, Dementia, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- SCIBHI (NCT01696019)
- Testing
- Fast walking, Tai Chi, Intellectual stimulation
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alzheimer Disease, Cognitive Decline
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Alzheimer's disease (AD) neuropathology is characterized by deposits of insoluble amyloid β-peptide (Aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles.
- Trial name
- (PENSA) (NCT03978052)
- Testing
- EGCG, Healthy lifestyle recommendations, Multimodal lifestyle intervention
- Where
- 2 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Physical Inactivity
Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease
This is a four-week pilot randomized controlled trial of a behavioral intervention in older adults at risk for Alzheimer's disease. Older participants are a subgroup from the PREVENT-AD longitudinal cohort.
- Trial name
- HABS (NCT06038643)
- Testing
- Motivational behavioural intervention and daily activities monitoring, Active Control
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Aging, Alzheimer Disease
The Nightlight Falls Prevention Study
This project will test the effectiveness of a novel intervention consisting of unobtrusive, low-intensity, horizontal and vertical lights that outline the bathroom or entry way doorframe in residents' rooms and provide visual…
- Conditions
- Aging, Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
- Trial name
- NCT05973448
- Testing
- Novel Lighting Condition, Control Lighting Condition
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- University of North Carolina, Chapel Hill
Alzheimer Disease, Glucose Metabolism
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence.
- Trial name
- KetoHome (NCT05642052)
- Testing
- low carb diet, Regular diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Alzheimer Disease or Associated Disorder, Mild to Moderately Severe Dementia
Effectiveness of Care Management in Alzheimer Patients
Context: The French Alzheimer plan 2008-2012 includes the implementation of "disease managers" or social workers, from the onset of the disease, for every patient with a diagnosis of Alzheimer disease or associated disorder.
- Trial name
- AIDALZ (NCT01081743)
- Testing
- Intervention of the social worker
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Institut de Sante Publique, d'Epidemiologie et de Developpement
Dementia
Handwriting as an Objective Tool to Support the Identification of People With Alzheimer's Disease
Alzheimer's disease (AD) is the most common of dementia, and has associated cognitive and motor disorders, with consequences on daily activities, including handwriting.
- Trial name
- HAD (NCT06483438)
- Where
- 3 sites in Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Évora
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Low Back Pain
Internet App to Self-Manage Occasional Low Back Pain
Nonspecific low back pain (NLBP) is the diagnosis for 85% of low back pain sufferers with no underlying medical cause (e.g., herniated disc, spinal stenosis) that requires physician care.
- Trial name
- BackPain2 (NCT01950091)
- Testing
- FitBack on-line intervention, Alternative Website Control
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Sexually Transmitted Diseases, Safe Sex
P3 (Prepared, Protected, emPowered)
P3 (Prepared, Protected, emPowered) is an interactive smartphone app for HIV-uninfected YMSM and YTW that utilizes social networking and game-based mechanics as well as a comprehensive understanding of what constitutes "best…
- Conditions
- Sexually Transmitted Diseases, Safe Sex, Adherence, Medication
- Trial name
- P3 (NCT03320512)
- Testing
- P3, P3+, Control
- Where
- 9 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression
Personalized Prevention of Depression in Primary Care
The main goal is to design, develop and evaluate a personalized intervention to prevent the onset of depression based on Information and Communications Technology (ICTs), risk predictive algorithms and decision support systems…
- Trial name
- NCT03990792
- Testing
- e-predictD intervention, Brief psychoeducational intervention
- Where
- 6 sites in Spain
- Volunteers
- 663 people
- Sponsor
- The Mediterranean Institute for the Advance of Biotechnology and Health Research