Clinical trials: Alzheimer Dementia
Alzheimer's Disease
AIDMA: A Psycho-educational Program Designed to Support and Train Carers of Alzheimer's Disease (AD) Patients
The aim of the project is to demonstrate that a psycho-educational programme designed to support and train carers of Alzheimer's disease (AD) patients induces a significantly higher benefit than anticholinesterase drug treatment…
- Trial name
- NCT00190372
- Testing
- Controlled diet, Self-hypnotic relaxation
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease, Dementia
A Study of the Safety and Effectiveness of Galantamine in Patients With Alzheimer's Disease
The purpose of this study is to evaluate the long-term efficacy and safety of galantamine in patients with Alzheimer's disease.
- Conditions
- Alzheimer Disease, Dementia, Mental Disorders, Brain Diseases
- Trial name
- NCT00216502
- Testing
- galantamine hydrobromide
- Volunteers
- 254 people
- Sponsor
- Janssen-Cilag S.p.A.
Dementia Alzheimers
Surface EMG to Measure Paratonia in Dementia
Rationale: A prominent and degenerative motor symptom of dementia is paratonia that heavily affects quality of life. However, paratonia is poorly recognized and the diagnosis yet relies on subjective evaluation by caregivers.
- Trial name
- NCT05606445
- Testing
- Elbow movement
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Alzheimer s Disease
Deep Cervical Lymphovenous Anastomosis for Severe Alzheimer's Disease
Alzheimer's disease (AD) is a severe neurodegenerative disease with heavy social burden. Current drugs cannot reverse disease progression.
- Trial name
- DCLVA-AD (NCT07669272)
- Testing
- Deep Cervical Lymphovenous Anastomosis, Routine Treatment
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Southwest Hospital, China
Amputation, Traumatic, Pain, Phantom
Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA)
In Ukraine, since the beginning of the full-scale war on February 24, 2022, a large number of individuals have lost a limb(s). Many of these amputees cannot access appropriate care in terms of pain management and rehabilitation.
- Conditions
- Amputation, Traumatic, Pain, Phantom, Pain, Acute, Pain, Chronic
- Trial name
- PAMELA (NCT06604507)
- Testing
- non-pharmacological app
- Where
- 5 sites in Ukraine
- Volunteers
- 200 people
- Sponsor
- Winfried Meißner
Dementia, Alzheimer Disease
Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing…
- Conditions
- Dementia, Alzheimer Disease, Infections
- Trial name
- TRAIN-AD 2 (NCT05950607)
- Testing
- TRAIN AD 2.0
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Hebrew SeniorLife
Dementia, Alzheimer Disease
Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
The goal of this clinical trial is to evaluate Kinto's Care Coaching intervention for dementia caregivers. The main questions it aims to answer are: Does the intervention help caregivers to address their general caregiving goals…
- Conditions
- Dementia, Alzheimer Disease, Lewy Body Disease, Vascular Dementia
- Trial name
- NCT05916664
- Testing
- Kinto Care Coaching
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Kinto
Alzheimer Disease
A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01
This is a Phase Ia/Ib, two-part, randomized, placebo-controlled, double-blinded, first in human(FIH) study to evaluate the safety, tolerability, PK, and PD of ADEL-Y01 in healthy participants in Part 1 and participants with MCI…
- Trial name
- NCT06247345
- Testing
- ADEL-Y01 - healty participants, ADEL-Y01 - MCI/AD
- Where
- 6 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Expert Lab (ADEL), Inc.
Alzheimer's Disease
Effects of LY450139, on the Progression of Alzheimer's Disease as Compared With Placebo
Alzheimer's disease (AD) is a fatal degenerative disease of the brain for which there is no cure. AD causes brain cells to die. AD is thought to be caused by an excess of beta amyloid (β-amyloid), a sticky protein in the brain…
- Trial name
- IDENTITY-2 (NCT00762411)
- Testing
- LY450139
- Where
- 91 sites in United States, Brazil and 16 more
- Volunteers
- 1,111 people
- Sponsor
- Eli Lilly and Company
Late Onset Epilepsy, Alzheimer Disease
Discard the Curative Causes of Late Onset Epilepsy: the Role of Brain 18F-FDG PET
Etiology and cognitive prognosis in late onset epilepsy differ from young adults epilepsy. At the epilepsy onset, this is crucial to detect potential curative/treatable brain disorders.
- Trial name
- EPITEP (NCT05831371)
- Testing
- TEP FDG
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Central Hospital, Nancy, France
Diabetes, Alzheimer Disease
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for…
- Conditions
- Diabetes, Alzheimer Disease, Dementia, Vascular, Dementia
- Trial name
- DPPOS-4 (NCT05704309)
- Where
- 27 sites in United States
- Volunteers
- 1,976 people, healthy volunteers welcome
- Sponsor
- Marinella Temprosa
Alzheimer Disease
Synbiotic Formula (SCV09) in Alzheimer's Disease Patients
In recent years, emerging studies have revealed the role of gut microbiota in human health and diseases, including AD and other neurodegenerative conditions5.
- Trial name
- NCT06948929
- Testing
- SCV09
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Neurodegenerative Disorders, Parkinson Disease
An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy
The aim of the study is to validate a salivary test that allows for rapid and accurate objective diagnosis in the context of neurodegenerative diseases, a complex of diseases that includes Alzheimer's Dementia, Frontotemporal…
- Conditions
- Neurodegenerative Disorders, Parkinson Disease, Alzheimer Disease, Parkinsonian Disorders
- Trial name
- SANDY (NCT06875739)
- Where
- 4 sites in Italy
- Volunteers
- 310 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Alzheimer Disease
Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and Apathy
The objective of this study is to demonstrate the impact of a socially assistive robot system on reducing apathy among cognitively impaired older adults residing in long term care facilities.
- Trial name
- NCT05178992
- Testing
- Socially Assistive Robot Activity
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Vanderbilt University
Alzheimer Disease, Subjective Cognitive Impairment
Comfortage - AD Prevention Strategies
Study is Interventional, cross-sectional, clinical trial without drug and without device
- Conditions
- Alzheimer Disease, Subjective Cognitive Impairment, Mild Cognitive Impairment
- Trial name
- Comfortage-P4 (NCT06896201)
- Testing
- Neuropsychological Assessments and Other Questionnaires, Blood Exams, Fluid Biomarkers, Genetics, Connectivity Analysis
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alzheimer's Disease
Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease
The primary objective of the study is to evaluate the efficacy of T-817MA in AD patients to treat dementia. Efficacy will be cognitive function, as measured by the ADAS-cog cognitive assessment.
- Trial name
- NCT00663936
- Testing
- T-817MA
- Where
- 35 sites in United States, Canada
- Volunteers
- 373 people
- Sponsor
- FUJIFILM Toyama Chemical Co., Ltd.
Alzheimer Disease
Assessment of Sleep Disturbance in Alzheimer Disease
The purpose of this study is to study circadian rhythms, or daily cycles of sleep, wake, and activity. The investigators hope to learn how disturbed sleep in Alzheimer's Disease relates to changes in activity cycles, and how…
- Trial name
- NCT00831298
- Testing
- Analysis of sleep disturbance
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Alzheimer Dementia, Parkinson Disease
Assessment of Empathetic Process by Scanpath Study of an Artwork
Analysis of gaze patterns during social cognition tasks and standardised exploration of a specific artwork, between elderly subjects without cognitive disorders and subjects with neurodegenerative diseases such as Fronto-Temporal…
- Conditions
- Alzheimer Dementia, Parkinson Disease, Fronto-Temporal Dementia
- Trial name
- EYE-EMPATH (NCT04665622)
- Testing
- Eye-Tracking / Neuropsychological evaluations
- Where
- Monaco
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Princesse Grace
Alzheimer Disease, CVA (Cerebrovascular Accident)
Open Label Trial of Rivastigmine Patch in Subjects With Mild to Moderate Stage AD Having Coexisting svCVD
Rivastigmine, an acetylcholinesterase inhibitor which has been approved by FDA \& HSA, is authorized for use in the treatment of mild to moderate dementia of the Alzheimer's type.
- Trial name
- NCT02444637
- Testing
- Rivastigmine
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National Neuroscience Institute
Covid19
Clinical Trial of the Immunogenicity, Safety, and Efficacy of the Gam-COVID-Vac Vaccine Against COVID-19 in Venezuela
Randomized, double-blind, placebo controlled clinical trial of immunogenicity, safety and efficacy of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults.
- Trial name
- VENEZUELA (NCT04642339)
- Testing
- Gam-COVID-Vac
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
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