Clinical trials: Alzheimer Dementia
Alzheimer's Disease
Efficacy and Safety of MNI-672 SPECT for Detection/Exclusion of Cerebral B-amyloid in AD Subjects Compared to HVs.
This is a Phase 1, single center, open-label, non-randomized, clinical study in probable AD patients and HVs to evaluate the efficacy, safety and tolerability of a single dose of MNI-672.
- Trial name
- NCT01859767
- Testing
- [123I]MNI-672 SPECT
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Familial Alzheimer Disease (FAD), PSEN1 Mutation
Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease
The goal of this clinical trial is to learn about safety and efficacy of bromocriptine in familial Alzheimer's disease with presenilin 1 mutations.
- Trial name
- REBRAnD (NCT04413344)
- Testing
- Bromocriptine Mesilate
- Where
- 8 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Kyoto University
Alzheimer Disease, Mild Cognitive Impairment
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment.
- Trial name
- BEAT-AD (NCT03472664)
- Testing
- low carbohydrate/high fat diet, low fat/high carbohydrate diet
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Wake Forest University Health Sciences
Dementia
D-CARE - The Dementia Care Study: A Pragmatic Clinical Trial of Health System-Based Versus Community-Based Dementia Care
D-CARE: The Dementia Care Study This pragmatic randomized clinical trial of 2150 persons with dementia and their caregivers, at four diverse clinical trial sites in the United States, compares the effectiveness and…
- Trial name
- D-CARE (NCT03786471)
- Testing
- Health System-based Dementia Care, Community-based Dementia Care, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 2,176 people
- Sponsor
- University of California, Los Angeles
Alzheimer's Disease
Open-label Extension Study in Participants With Early Alzheimer's Disease
The study medicine GSK4527226 is being studied in participants with Alzheimer's Disease (AD) in study 219867 (the parent study, NCT06079190).
- Trial name
- NCT07105709
- Testing
- GSK4527226
- Where
- 33 sites in United States, Argentina and 9 more
- Volunteers
- 220 people
- Sponsor
- GlaxoSmithKline
Alzheimer Disease
Study Evaluating Lecozotan SR in Mild to Moderate Alzheimer's Disease (AD)
The purpose of this study is determine the safety, tolerability, and efficacy of 3 doses of lecozotan SR in patients with mild to moderate Alzheimer's Disease over 12 weeks.
- Trial name
- NCT00151398
- Testing
- lecozotan SR, Donepezil
- Where
- 56 sites in United States, Argentina and 3 more
- Volunteers
- 229 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Alzheimer Disease, Dementia Frontal
Evidence Amyloid Scan EEG Study
The Evidence Amyloid Study EEG (EASE) establishes an open-label, longitudinal cohort study to measure of neurological functioning during the onset and progression of cognitive decline in preclinical Alzheimer's patients using…
- Conditions
- Alzheimer Disease, Dementia Frontal, Mild Cognitive Impairment
- Trial name
- EASES (NCT03644043)
- Testing
- EEG scan
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Metabolic Therapy Inc.
Alzheimer Disease, Dementia
Moving Together: An Online Group Movement Program for People Living With Memory Loss and Caregivers
To determine whether Moving Together improves quality of life in people with memory loss (PWML) and caregivers (CG) by performing a randomized, controlled trial (RCT) with a waitlist control group in 224 dyads.
- Trial name
- NCT04621448
- Testing
- Moving Together
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of California, San Francisco
Mild to Moderate Alzheimer's Disease
The Effect of CB-Exo-A600 in Mild to Moderate Alzheimer's Disease
This study is divided into two phases: a dose-escalation phase and an expansion cohort phase. The dose-escalation phase is a single-center study, while the expansion cohort phase is a multicenter, prospective, randomized…
- Trial name
- CB-EXOAD (NCT07457125)
- Testing
- Exosomes derived from umbilical cord mesenchymal stem cell for intranasal drop
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer's Disease
Alzheimer's Disease Biomarkers in Cerebrospinal Fluid in Insulin-resistant Men
Type 2 diabetes mellitus has been associated with an about 2-fold increase in risk of Alzheimer's disease (AD). Patients with AD have been reported to have reduced insulin sensitivity.
- Trial name
- ADDM (NCT02010476)
- Where
- Finland
- Volunteers
- 58 people
- Sponsor
- University of Eastern Finland
Dementia, Alzheimer Disease
Volumetric Magnetic Resonance Imaging in Dementia
Dementia is a term for the impaired ability to remember, think, or make decisions that interferes with doing everyday activities. Alzheimer's disease is the most common type of dementia.
- Trial name
- NCT05119114
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Cognitive Impairment, Alzheimer Disease
A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dement
- Trial name
- HERITAGE (NCT05886114)
- Testing
- Structured Multi-domain Intervention, Self-Guided Intervention
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Diet Modification, Cognitive Decline
Multicultural Healthy Diet to Reduce Cognitive Decline
This is a pilot randomized controlled clinical trial is designed to investigate whether the Multicultural Healthy Diet (MHD), an anti-Inflammatory diet tailored to a multi-cultural population, can improve cognitive functioning in…
- Conditions
- Diet Modification, Cognitive Decline, Cognitive Change
- Trial name
- MHD (NCT03240406)
- Testing
- Multicultural Healthy Diet, Usual Diet plus Self-Care
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
A Pilot Study to Examine the Effect of Egb761 on Plasma Biomarker Levels and on Cognitive Function in Patients With MCI
The goal of this clinical trial is to learn if the drug Egb761, produced from Ginkgo Biloba extract, works to improve the blood level of a biomarker of Alzheimer's disease, called phosphorylated-tau217 (p-tau217), which serves as…
- Trial name
- NCT07287852
- Testing
- Ginkgo Biloba Extract 761
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Alzheimer Disease
A Study to Evaluate the Efficacy and Safety of Brain Polypeptide Solution in Mild Alzheimer's Disease
In recent years, reduced levels of brain-derived neurotrophic factor (BDNF) have been found in dementia patients. BDNF reduces amyloid precursor protein (APP) fragments via the Trk signaling pathway, and the expression of…
- Trial name
- NCT03978338
- Testing
- brain polypeptide solution
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Alzheimer Disease, Telerehabilitation
Comparison of the Effect of Online Physical Exercise and Computerized Cognitive Stimulation in Patients With Alzheimer's Disease
Our aim has been determined to investigate the effect of physical exercise alone and in combination with cognitive exercise, on cognitive, physical function and quality of life in individuals with Alzheimer's Disease during the…
- Conditions
- Alzheimer Disease, Telerehabilitation, Online Physical Exercise, Computerized Cognitive Stimulation
- Trial name
- NCT04842734
- Testing
- Physical exercise, Physical exercise and computerized cognitive training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yeditepe University
Alzheimer's Disease, Dementia
LifeZig Personalized Reminiscence Video With Slideshows and Music for Individuals With Alzheimer's and Dementia
The LifeZig Project is a research study of a new reminiscence activity for individuals with Alzheimer's Disease (AD) and other types of dementia, based on the LifeZig system, with personalized video channels containing old…
- Trial name
- Lifezig (NCT00759863)
- Testing
- Lifezig
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Photozig, Inc.
Mild Cognitive Impairment, Alzheimer Disease
Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study
850,000 people live with dementia in the UK, with that number expected to rise to more than 1 million within the next 5 years. The most common type of dementia (55%) is Alzheimer's dementia, and vascular dementia is the second…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Vascular Dementia, Healthy Controls
- Trial name
- NCT03134963
- Testing
- Transcranial doppler ultrasonography, Blood pressure monitoring, Heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Alzheimer's Disease
AZD3293 Thorough QT Study in Healthy Male Volunteers
A thorough QT study of AZD3293
- Trial name
- AZD3293TQT (NCT02040987)
- Testing
- AZD3293, Moxifloxacin
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mild Cognitive Impairment
An Observational Study for Analysis of Mortality in Participants Who Participated in Previous 3 Studies of Galantamine
The purpose of the study is to collect data of patients who were randomized (assignment of study medication by chance) and treated in 3 previous studies of galantamine (CR003145, CR002014 and CR005947) for the treatment of mild…
- Trial name
- NCT00297414
- Testing
- No intervention
- Where
- 144 sites in United States, Argentina and 14 more
- Volunteers
- 1,083 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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