Clinical trials: Alzheimer Dementia
Alzheimer Disease
Open Label Study of ATH-1017 for Treatment of Mild to Moderate Alzheimer's Disease
The objective of this study is to determine the safety and tolerability of fosgonimeton (ATH-1017) in subjects with mild to moderate Alzheimer's disease who completed the 26-week randomized treatment in Study ATH-1017-AD-0201 or…
- Trial name
- NCT04886063
- Testing
- ATH-1017
- Where
- United States
- Volunteers
- 423 people
- Sponsor
- LeonaBio
Alzheimer Disease
Deep Brain Stimulation of the Pedunculopontine Nucleus for Alzheimer's Disease
Alzheimer's disease (AD) is a brain disorder that gradually impacts cognitive functions such as memory, thinking, and daily functioning.
- Trial name
- DBS-PPN-AD (NCT06936124)
- Testing
- Deep Brain Stimulation of the Pedunculopontine Nucleus
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Healthy Volunteers
A Study to Assess the Adverse Events and How Oral ABBV-552 Capsules Moves Through the Body of Healthy Adult Japanese and Han Chinese Participants
This study will assess how safe ABBV-552 is and how ABBV-552 moves through the body of adult healthy Japanese and Han Chinese participants. Adverse Events will be assessed.
- Trial name
- NCT05686980
- Testing
- ABBV-552
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AbbVie
Alzheimer's Disease
Project ACT: Advancing Caregiving Techniques
The specific aims of this study are to: 1. Test the immediate effectiveness of the intervention to reduce caregiver upset with targeted disruptive behaviors (primary outcome).
- Trial name
- NCT00259480
- Testing
- Home Based Intervention
- Where
- United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Alzheimer Disease, Dementia
Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers
There is a need for caregiver-initiated and -implemented non-pharmacological interventions directly to and for the person with dementia, including environmental assessment and modification, as first-line treatments for behavioral…
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05202223
- Testing
- Harmony at HOME (H@H)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Elizabeth K Rhodus
Alzheimer Disease
Information About Alzheimer's Disease for Latinos in New York City
This study will assess the psychosocial and behavioral impacts of receiving Alzheimer's disease genetic risk assessment incorporating APOE genotypes among Latinos in northern Manhattan.
- Trial name
- IDEAL (NCT04471779)
- Testing
- Disclosure of APOE genotype
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Columbia University
Alzheimer Type Dementia
Efficacy and Safety of DMB-I (INN: Latrepirdine) in Patients With Alzheimer Type Dementia
The goal of this clinical study is to learn if the study drug DMB-I (INN: Latrepirdine) works to treat Alzheimer type dementia in adults. It will also learn about the safety of DMB-I (INN: Latrepirdine).
- Trial name
- NCT07251023
- Testing
- DMB-I (INN: Latrepirdine), Memantine Hydrochloride 20 MG
- Where
- 12 sites in Russia
- Volunteers
- 450 people
- Sponsor
- Bigespas LTD
Decision Making
Alzheimer's Family Research
This is a research study about how family members make research participation decisions for a relative with Alzheimer's or a related dementia.
- Trial name
- NCT00878059
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer Disease, Preclinical Alzheimer
β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline
The overall (cross-sectional) objective of this study is to detect and describe the profile of AD-related blood biomarkers in a population with SCD (including individuals with MCI) with the ultimate goal of investigating their…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer, Mild Cognitive Impairment
- Trial name
- β-AARC (NCT04935372)
- Testing
- Observational
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Alzheimer's Disease
A Study of PRX-03140 in Subjects With Alzheimer's Disease Receiving a Stable Dose of Donepezil
A randomized placebo-controlled study to evaluate the efficacy of PRX-03140 in subjects with Alzheimer's Disease receiving a stable dose of donepezil. The study consists of a 26-week double-blind treatment period.
- Trial name
- NCT00672945
- Testing
- PRX-03140
- Where
- 38 sites in United States
- Volunteers
- 420 people
- Sponsor
- Epix Pharmaceuticals, Inc.
Alzheimer Disease
Safety, Tolerability, and Pharmacokinetics Study of NDX-1017
This Phase 1 randomized, placebo-controlled, double-blinded, first-in-human study will evaluate safety, tolerability, and pharmacokinetics of single and multiple ascending doses of NDX-1017 in healthy young and elderly subjects…
- Trial name
- NCT03298672
- Testing
- NDX-1017
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- LeonaBio
Alzheimer Disease, Dementia
An Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease
The goal of this Phase 2 Open Label study is to evaluate long-term safety, tolerability, and efficacy of XPro1595 on measures of cognition, function and brain quality in individuals with Alzheimer's Disease.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05522387
- Testing
- XPro1595
- Where
- 4 sites in Australia
- Volunteers
- 11 people
- Sponsor
- Inmune Bio, Inc.
Parkinson Disease, Epilepsy
In Vivo Imaging of Therapeutic Electric Current Flow
The purpose of this research study is to measure current flow inside the head using magnetic resonance imaging (MRI). The data from this study will be used to map the current flow caused from the electrical stimulation inside the…
- Conditions
- Parkinson Disease, Epilepsy, Alzheimer's Disease, Stroke
- Trial name
- tDCS (NCT02453763)
- Testing
- Transcranial direct current stimulation, MRI
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer's Disease, Gait Apraxia
Alzheimer's Disease and Related Disorders
The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild…
- Conditions
- Alzheimer's Disease, Gait Apraxia, Impaired Cognition
- Trial name
- MERE (NCT01315704)
- Testing
- Drug intervention
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Anxiety, Depression
Remember Stuff: A Dyadic-focused Technology to Support Persons With Alzheimer's Disease in the Community
Test the usability, perceptions and acceptability of a computer monitor for participant diagnosed with ADRD and their caregiver who will program the applications specifically for each individual to help them remember activities…
- Conditions
- Anxiety, Depression, Caregiver Burnout, Anxiety Generalized
- Trial name
- R/S (NCT04626804)
- Testing
- Remember Stuff: A Dyadic-focused Technology to Support Persons with Alzheimer's Disease in the Community
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Alzheimer's Type Dementia
Intensive Instruction on the Use of Aricept
The purpose of this study is to examine the influence of the instruction on the use of Aricept with educational brochure on the 48-week medication persistence and to assess the reasons for discontinuation.
- Trial name
- NCT01972204
- Testing
- Intensive adherence instruction, Control
- Where
- Japan
- Volunteers
- 125 people
- Sponsor
- Mirai Iryo Research Center, Inc.
Alzheimer Disease
A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers
The objective of this study is to compare the effectiveness of 2 intervention delivery strategies for increasing moderate physical activity (MPA), real-time group video conferencing (RGV) vs.
- Trial name
- NCT04102514
- Testing
- Real-time Group Video, Enhanced Usual Care
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- University of Kansas
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute
Amnestic Mild Cognitive Impairment - aMCI, AD-MCI
Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment
This study aims to evaluate the efficacy and safety of temporal interference stimulation (TIS), a non-invasive neuromodulation technique, in improving cognitive function in patients with cognitive impairment.
- Conditions
- Amnestic Mild Cognitive Impairment - aMCI, AD-MCI, AD - Alzheimer's Disease, FTD
- Trial name
- TIS (NCT07643363)
- Testing
- Temporal Interference Stimulation, Targeted Cognitive Training, General Cognitive Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Alzheimer's Disease
Can the Assessment of the Subhippocampal Region Contribute to the Detection of Early Diagnosis of Alzheimer's Disease? A Validation Study Using PET With Florbetapir (AV-45).
Reliable diagnosis of Alzheimer's Disease (AD) at the predementia stage is currently considered to be a priority for research, as disease modifying therapies are being evaluated.
- Trial name
- NCT01746706
- Testing
- PET amyloid tracer (Florbetapir F18 AV45 F18
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
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