Clinical trials: Alzheimer Dementia
Alzheimer Disease, Memory Loss
Home-based Brain Stimulation for Memory
The proposed project aims to systematically examine the feasibility of remote, caregiver-led tACS for older adults who are vulnerable to memory decline.
- Trial name
- MemStim-home (NCT04783350)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Alzheimer's Disease
Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease
In this explorative longitudinal study 50 patients with Alzheimer's disease (AD) and 50 age-matched control subjects will be recruited for their 2 years follow-ups and undergo extensive cognitive testing and quantitative 3 Tesla…
- Trial name
- NCT02752750
- Testing
- MRI
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Alzheimer Disease, Benson's Disease
Tau Brain Imaging in Typical and Atypical Alzheimer's Disease (AD)
Recently revised Alzheimer Disease (AD) diagnostic1described nonamnestic presentations: 1/ language presentation (logopenic progressive aphasia) 2/ visuospatial presentation (posterior cortical atrophy or PCA) and 3/ executive…
- Trial name
- TEPTAU (NCT03022968)
- Testing
- [18F]T807 PET
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Alzheimer Disease, Mild Cognitive Impairment
Clinical Evaluation of Florbetapir F 18 (18F-AV-45)
This protocol is designed to standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden in subjects participating in other studies (companion protocol) such as longitudinal studies of aging…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neurodegenerative Diseases
- Trial name
- NCT01518374
- Testing
- Florbetapir F 18
- Where
- 26 sites in United States
- Volunteers
- 1,768 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Dementia of Alzheimer Type
THE EFFECT OF REMOTE NURSING INTERVENTIONS BASED ON THE EMPOWERMENT PROCESS MODEL ON PEOPLE WITH DEMENTIA AND THEIR FAMILY CAREGIVERS
In this study, it is planned to evaluate the effect of remote nursing interventions based on the empowerment model on individuals with dementia and family caregivers. It was designed as a mixed method research.
- Trial name
- NCT07010874
- Testing
- REMOTE NURSING INTERVENTIONS BASED ON THE EMPOWERMENT PROCESS MODEL
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Alzheimer Disease
An Exploratory Study of Near-infrared Light Therapy for Mild to Moderate Alzheimer's Disease
This is an exploratory clinical study to evaluate the efficacy and safety of near-infrared light therapeutics in the treatment of mild to moderate Alzheimer's disease.
- Trial name
- NCT06836180
- Testing
- Near infrared light therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer's Disease
A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD).
This randomized, double-blind, placebo-controlled, parallel group study will evaluate the efficacy and safety of crenezumab versus placebo in participants with prodromal to mild AD.
- Trial name
- CREAD (NCT02670083)
- Testing
- Crenezumab
- Where
- 196 sites in United States, Australia and 28 more
- Volunteers
- 813 people
- Sponsor
- Hoffmann-La Roche
Dementia, Alzheimer Disease
Systematic Multi-domain Alzheimer's Risk Reduction Trial
The primary goal of this randomized controlled trial (RCT) is to pilot-test a personalized, pragmatic, multi-domain Alzheimer's disease risk reduction intervention in a U.S. integrated healthcare delivery system.
- Trial name
- SMARRT (NCT03683394)
- Testing
- SMARRT Intervention, Health Education Intervention
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Kaiser Permanente
Alzheimer Disease, Dementia
A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease
The purpose of this study is to collect and compare information regarding the treatment and outcome of patients diagnosed with Alzheimer's disease who are receiving either drug or nondrug treatment.
- Conditions
- Alzheimer Disease, Dementia, Nervous System Diseases, Mental Disorders
- Trial name
- NCT00291421
- Volunteers
- 2,360 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Alzheimer Disease, Mild Cognitive Impairment
COMMETS- Combination MCI Metabolic Syndrome
The investigators propose a proof of concept RCT (randomized clinical trial), testing the efficacy of intranasal insulin (INI) with semaglutide, a combination therapy with strong biological plausibility to benefit impaired…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Metabolic Syndrome
- Trial name
- NCT06072963
- Testing
- Semaglutide, Intranasal insulin
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Mild Cognitive Impairment, Early Alzheimer's Disease
Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease
The purpose of this study is to determine whether daily treatment with this new treatment approach, called COT would be effective in protecting the memory and brain regions of people who are already showing signs of memory loss.
- Conditions
- Mild Cognitive Impairment, Early Alzheimer's Disease, Memory Impairment
- Trial name
- NCT05122598
- Testing
- COT
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Evon Medics LLC
Alzheimer's Disease
Evaluate the Safety and Efficacy of AD-35 Tablet in Subjects With Mild to Moderate Alzheimer's Disease
Brief summary: This is a phase II study to investigate the safety, preliminary efficacy and pharmacokinetics of AD-35 tablet in patients with mild to moderate Alzheimer's Disease.
- Trial name
- WAY (NCT03790982)
- Testing
- AD-35 60 mg
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Healthy Aging
Modulating the Locus Coeruleus Function
The purpose of this study is to investigate the impact of transcutaneous vagus nerve stimulation (tVNS) on specific brain regions involved in memory and attention processes.
- Trial name
- NCT04877782
- Testing
- Transcutaneous vagus verne stimulation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Alzheimer's Disease
Alzheimer's Disease Long-term Follow-up Study (ALF Study)
Open study for efficacy and safety of donepezil treatment during 48 weeks
- Trial name
- NCT00165724
- Testing
- Donepezil Hydrochloride
- Where
- 7 sites in South Korea
- Volunteers
- 114 people
- Sponsor
- Eisai Korea Inc.
Dementia, Dementia, Vascular
Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia
This international study evaluates the impact of home-based caregiver-delivered music and reading interventions for people with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia, Mixed
- Trial name
- HOMESIDE (NCT03907748)
- Testing
- Music Intervention, Reading Intervention
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 864 people
- Sponsor
- Anglia Ruskin University
Alzheimer Disease, Cognitive Function
A Based on PEEG and PET Study of Anxiolytic Treatment to Improve Cognitive Function in Patients With Alzheimer Disease
Objective: Evaluation the improvement of the cognitive function of tandospirone add-on treatment on patients with AD comorbid anxiety.
- Trial name
- NCT03151382
- Testing
- Tandospirone Citrate, Donepezil Hydrochloride
- Volunteers
- 30 people
- Sponsor
- Zhejiang Provincial People's Hospital
Alzheimer Disease
Assessment of Initial Efficacy and Safety of High Intensity Focused Ultrasound 'ExAblate 4000 Type 2' for Blood Brain Barrier Disruption in Patients With Alzheimer's Disease
The proposed study is to evaluate initial efficacy and safety of the BBB disruption with transcranial MRI-guided focused ultrasound (ExAblate 4000 type 2.0) in patients with Alzheimer's disease.
- Trial name
- NCT04526262
- Testing
- transcranial magnetic resonance guided focused ultrasound BBB disruption
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Yonsei University
Memory Disorders, Alzheimer Disease
Memory Problems Perceptions Among Patients and Accompaniers During Diagnosis Process :
This study aims to prospectively examine the memory problem perceptions of patients with memory complaints [MCs] and their accompaniers during the diagnostic process.
- Trial name
- REMAD (NCT02299154)
- Testing
- Psychological questionnaires
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Alzheimer's Disease
Clinical Safety and Efficacy Evaluation of NanoLithium® NP03 in Patients With Mild-to-severe Alzheimer's Disease
This proof-of-concept study will assess safety, tolerance, and efficacy of NanoLithium® NP03 in patients with mild-to-severe Alzheimer's Disease (AD).
- Trial name
- NanoLi®_AD (NCT05423522)
- Testing
- NanoLithium® NP03
- Where
- 8 sites in France
- Volunteers
- 72 people
- Sponsor
- Medesis Pharma SA
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