Clinical trials: Alzheimer Dementia
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Alzheimer Disease, Physical Activity
Inspiring Seniors Towards Exercise Promotion to Protect Cognition
The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults with subjective memory complaints.
- Trial name
- iSTEP+ (NCT06496425)
- Testing
- Beat-accentuated, personalized music stimulation (BMS), Strength Training (ST), Aerobic exercise (AE)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Alzheimer Disease
Alzheimer's Disease Acitretin Medication
The trials investigates the changes of cerebral spinal fluid (CSF) soluble alpha-secretase cleaved APP (APPsα) levels under oral therapy with acitretin 30mg daily in patients with mild to moderate Alzheimer's disease (AD).The…
- Trial name
- ADAM (NCT01078168)
- Testing
- Acitretin
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- K. Lieb
Alzheimer Disease
Neurofeedback in Alzheimer's Disease
This study will evaluate behavioral and electrophysiological changes in a sample of adults with possible or probable Alzheimer's disease (AD), before and after undergoing training using a brain-computer interface (BCI) system…
- Trial name
- NCT03790774
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Alzheimer Disease, Memory Complaint
Investigation of AlzHeimer's Predictors in Subjective Memory Complainers - Extension Study
A regional, single-center, prospective, observational academic cohort will follow subjects who previously participated in the INSIGHT study and who agree an extension of their follow-up in the INSIGHT-2 research for additional…
- Conditions
- Alzheimer Disease, Memory Complaint, Memory Disorders
- Trial name
- INSIGHT-2 (NCT05806697)
- Testing
- Electroencephalogram (EEG), Oculomotor tests, MRI
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dementia, Cognitive Decline
Investigating Neurocognitive Disorders Epidemiology
This is a prospective cohort study with the main purpose of predicting progression neurocognitive disorders in Thai population. The main predictor variables to be evaluated are plasma phosphorylated tau (p-tau) level and…
- Conditions
- Dementia, Cognitive Decline, Alzheimer Disease
- Trial name
- INDE (NCT06375213)
- Testing
- Plasma tau phosphorylated at Thr217, Neurocognitive examination
- Where
- Thailand
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Dementia
The Genetic Characterization of Dementia
Background: Researchers are interested in learning more about dementia and its causes. They want to look at the genetic basis of dementia.
- Trial name
- NCT01867359
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Dementia, Alzheimer Disease
Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA
The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- Tele-STELLA (NCT04627662)
- Testing
- Tele-STELLA
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Oregon Health and Science University
Blood Brain Barrier, Alzheimer Disease
The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease
This study attempts to replicate the findings published in Nature Medicine by Nation and colleagues (2019). By using a large observational cohort (DZNE - Longitudinal Cognitive Impairment and Dementia Study; DELCODE) consisting…
- Conditions
- Blood Brain Barrier, Alzheimer Disease, Cognitive Dysfunction, Dementia
- Trial name
- NCT04093882
- Testing
- Contrast agent enhanced MRI using Gadovist
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alzheimer Disease, Mild Cognitive Impairment
Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation
Presently, few studies have evaluated the clinical impact of rTMS in Alzheimer's disease. Though some studies have demonstrated an improvement, there have been conflicting results, as others do not seem to demonstrate beneficial…
- Trial name
- StimoLaMente (NCT04866979)
- Testing
- Experimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT).
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi di Trento
Mild Cognitive Impairment, Cognitive Change
Conversations as a Means to Delay the Onset of Alzheimer's Disease
Past epidemiological studies have demonstrated that larger social networks, or more frequent social interactions, could have potential protective effects on the incidence of Alzheimer's Disease (AD).
- Trial name
- conversation (NCT01571427)
- Testing
- Active social engagement group, Control group
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn
Alzheimer's Disease
Continuous Arterial Spin Labeling (CASL) MRI for Monitoring and Prediction of Drug Therapy in Alzheimers Disease (AD)
Examination of the correlation between the cerebral bloodflow and the clinical change under treatment with Reminyl retard® and the prediction of clinical change by measuring the cerebral bloodflow in patients with mild to…
- Trial name
- CASL-AD-01 (NCT00637442)
- Testing
- Reminyl retard
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Alzheimer's Disease
Telephone Resources and Assistance for Caregivers (TRAC)
The purpose of this randomized clinical trial is to test a 12-month multi-component health promotion intervention with home-based family caregivers of persons with Alzheimer's Disease and other related dementias.
- Trial name
- TRAC (NCT00721383)
- Testing
- Enhancing Physical Activity Intervention, CSBI
- Where
- 2 sites in United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Alzheimer's Disease, rTMS Stimulation
The Underlying Neural Mechanism of TMS in Improving the Imbalance of "Microbiota-brain-gut Axis" in Alzheimer 's Disease Population
What is this study about? This study focuses on Alzheimer's Disease (AD), a common neurodegenerative disease that affects memory, thinking, and daily life.
- Trial name
- NCT07346794
- Testing
- TMS
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
FTD, AD
Metabolic Characterization of Alzheimer's Disease and Frontotemporal Dementia by 23Na-MRI and FDG-PET
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common forms of neurodegenerative dementia. However, their differential and timely diagnosis can be challenging for clinicians, therefore often closing the…
- Conditions
- FTD, AD, Healthy Controls
- Trial name
- MetaAD_FTD (NCT07100470)
- Testing
- Sodium MRI
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Alzheimer's Disease (AD) and Related Disorders
Non-pharmacological Care of Alzheimer's Disease: Benefice of Musical Interventions
Cares of Alzheimer's disease (AD) and related disorders are presenting a real public health challenge. Because of the limited effectiveness of pharmacological treatments, there is a growing interest in care approach based on…
- Trial name
- MusicAlzheimer (NCT02833870)
- Testing
- Musical intervention, Non-musical (cooking) intervention, Control with no intervention
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Dementia, Undernutrition
nuTritiOn and deMentia AT hOme (TOMATO)
The purpose of this study is to refine, implement and assess the acceptability and feasibility of an existing nutrition intervention applied to people living with dementia receiving home care.
- Trial name
- TOMATO (NCT05866094)
- Testing
- Nutritional Intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 139 people
- Sponsor
- Bournemouth University
Alzheimer's Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
[18F]APN-1607 PET in Subjects With AD Compared to HC
The overall objective of this study is to compare the overall pattern of [18F]APN-1607 uptake in subjects with MCI, subjects with AD dementia, and healthy subjects.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment Due to Alzheimer's Disease, Healthy Volunteers
- Trial name
- NCT05542953
- Testing
- [18F]APN-1607
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- APRINOIA Therapeutics
Sedentary Behavior, Physical Inactivity
Promoting Physical Activity in Older Hispanic/Latino(a) Adults
In this randomized controlled trial, study staff will randomize 130 Hispanic/Latino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted…
- Conditions
- Sedentary Behavior, Physical Inactivity, Alzheimer Disease, Protection Against
- Trial name
- NCT06362824
- Testing
- De Pie Intervention, Active Comparison Group: Healthy Actions And Lifestyles To Avoid Dementia (HALT-AD)
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
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