Clinical trials: Alzheimer Dementia
Alzheimer Disease
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the…
- Trial name
- AMPAlz (NCT06880406)
- Testing
- MMSE and blood draw
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Suspected Non-Alzheimer Disease Pathophysiology (SNAP)
Cognitive Effects of Theta-burst Stimulation (TBS) in Suspected Non-Alzheimer Disease Pathophysiology (SNAP)
This is a pilot study to identify a homogeneous cohort of pathologically specific dementia with SNAP for clinical trial of brain stimulation.
- Trial name
- SNAP (NCT05440110)
- Testing
- active and active TBS
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- Chang Gung Memorial Hospital
Caregiver Burden, Alzheimer Disease
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms in Hispanic Individuals
This study is a randomized, controlled trial (RCT) to evaluate usability and acceptability, and met and unmet needs from a caregiver intervention app, Brain CareNotes, among unpaid Hispanic caregivers of patients with dementia.
- Trial name
- NCT06099197
- Testing
- Brain CareNotes, Dementia Guide Expert
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Indiana University
Dementia Alzheimers
Assessing an Intergenerational Music Program Delivered by Adolescents to Older Adults With Declining Cognition
Intergenerational music programming has been shown to benefit both young people and older adults in terms of quality of life, social connection, and promotion of positive cross-age attitudes.
- Trial name
- NCT04645017
- Testing
- Intergenerational Music Program
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Cognitive Decline, Cognitive Dysfunction
Brain Vascular and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of transcranial photobiomodulation on indices of cerebral vascular health and neurocognitive function.
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
- Trial name
- NCT06497413
- Testing
- Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Alzheimer's Disease
Trial of Rifaximin in Probable Alzheimer's Disease
This study aims to improve cognition and function in patients with Alzheimer's Disease (AD) by administering the oral antibiotic, Rifaximin.
- Trial name
- NCT03856359
- Testing
- Rifaximin 550 milligrams (MG)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Alzheimer Dementia, Alzheimer Disease
Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy
The goal of this clinical trial is to determine if utilizing the Quest AD-Detect blood test, while patient's are hospitalized for a cognitive diagnosis (such as delirium or encephalopathy), will result in an earlier diagnosis of…
- Conditions
- Alzheimer Dementia, Alzheimer Disease, Delirium Confusional State, Encephalopathy
- Trial name
- NCT07222280
- Testing
- Quest AD-Detect blood test
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Covenant Health, US
Alzheimer s Disease, Occupational Therapy
Multisensory Environment-Based Occupational Therapy for Alzheimer's Patients
This study aims to examine the effects of a multisensory environment-based occupational therapy intervention on sensory processing, cognitive functions, behavioral and psychological symptoms, and caregiver burden in individuals…
- Conditions
- Alzheimer s Disease, Occupational Therapy, Rehabilitation, Caregiver Burnout
- Trial name
- NCT07279103
- Testing
- Multisensory Environment-Based Occupational Therapy, Occupational therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Mild to Moderate Alzheimer Disease, Cognitive Impairment
An Efficacy and Safety Study of Sodium Oligo-mannurarate (GV-971) Capsule for the Treatment of Alzheimer's Disease
The primary purpose of this study is to determine the efficacy and safety of Sodium Oligo-mannurarate (GV-971) in 36-week treatment of mild to moderate Alzheimer's disease.
- Trial name
- NCT02293915
- Testing
- Sodium oligo-mannurarate 900mg
- Where
- 16 sites in China
- Volunteers
- 818 people
- Sponsor
- Shanghai Greenvalley Pharmaceutical Co., Ltd.
Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia
Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and…
- Conditions
- Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Non Pharmacological Intervention
- Trial name
- MUSENGAGE (NCT06688968)
- Testing
- neuropsychologist interview, questionnaire
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cognitive Impairment
Ascending Dose Study of CT1812 in Healthy Volunteers
This is a double-blind, placebo controlled, ascending dose, multi-cohort trial. The study will be conducted in two phases: a single ascending dose (SAD) phase "Part A", followed by a multiple ascending dose (MAD) phase "Part B".
- Trial name
- NCT02570997
- Testing
- CT1812
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cognition Therapeutics
Alzheimer's Disease
Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease
This is a global Phase III, randomized, double-blinded, placebo-controlled study for subjects with evidence of early AD. The protocol is designed to determine whether ALZT-OP1 combination treatment (ALZT-OP1a + ALZT-OP1b) will…
- Trial name
- COGNITE (NCT02547818)
- Testing
- ALZT-OP1a, ALZT-OP1b
- Where
- 121 sites in United States, Australia and 5 more
- Volunteers
- 620 people
- Sponsor
- AZTherapies, Inc.
Alzheimer's Disease
A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in participants with mild to moderate Alzheimer's disease.
- Trial name
- NCT00566397
- Testing
- PF-04494700
- Where
- 62 sites in United States
- Volunteers
- 402 people
- Sponsor
- Pfizer
Alzheimer Disease
Study Evaluating the Safety, Tolerability, and Efficacy of Lecozotan SR in Outpatients With Alzheimer's Disease
The purpose of the study is to determine the safety, tolerability, and efficacy of 3 doses of lecozotan in combination with a cholinesterase inhibitor in patients with mild to moderate Alzheimer's disease (AD).
- Trial name
- NCT00277810
- Testing
- lecozotan SR (SRA-333)
- Where
- 83 sites in United States, Argentina and 9 more
- Volunteers
- 250 people
- Sponsor
- Pfizer
Dementia, Alzheimer's Disease
Virtual Reality Intervention for the Reduction of Behavioral and Psychological Symptoms of Dementia
Alzheimer's disease and related disorders (AD2) are characterised by cognitive changes and Behavioural and Psychological Symptoms of Dementia (BPSD).
- Conditions
- Dementia, Alzheimer's Disease, Neurocognitive Disorders
- Trial name
- LUMEENCOMPAD (NCT04769024)
- Testing
- LUMEEN Virtual Reality sessions, Control/non-digital stimulation sessions
- Where
- 6 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Traumas, Brain, Alzheimer Disease
The COACH Project: Combined Online Assistance for Caregiver Health
This study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for Veterans with a TBI or dementia.
- Conditions
- Traumas, Brain, Alzheimer Disease, Dementia, Head Injury
- Trial name
- COACH (NCT03123224)
- Testing
- Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Alzheimer's Disease, Mild Cognitive Impairment
Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)
The main purpose of this study is to assess the ability of a repeated high-frequency site-based computerized cognitive assessment to evaluate the potential treatment effects of donepezil (MK-0000) compared with placebo among…
- Trial name
- NCT04730635
- Testing
- Donepezil
- Where
- 10 sites in United States, Australia
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease
Escitalopram for the Treatment of Depression in Alzheimer's Disease
Purpose : to Evaluation of the Efficacy of Escitalopram for the Treatment of Depression in Alzheimer's Disease Trial Design : A 12-week, randomized, double-blind, parallel-group, placebo-controlled trial with an open-label…
- Trial name
- Escitalopram (NCT01841125)
- Testing
- escitalopram
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Konkuk University Medical Center
Alzheimer Disease, Dementia
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
The reason for this study is to assess the safety and efficacy of donanemab in participants with early Alzheimer's disease. The study duration including screening and follow-up is up to 93 weeks.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05508789
- Testing
- Donanemab
- Where
- 141 sites in Argentina, Australia and 6 more
- Volunteers
- 1,500 people
- Sponsor
- Eli Lilly and Company
Alzheimer's Disease
A Study Assessing Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease
This is a randomized double-blind placebo-controlled study comparing different doses of bryostatin for the treatment of moderately severe to severe Alzheimer's disease.
- Trial name
- NCT02431468
- Testing
- Bryostatin 1
- Where
- 29 sites in United States
- Volunteers
- 147 people
- Sponsor
- Neurotrope Bioscience, Inc.
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