Clinical trials: Alzheimer Dementia
Alzheimer Disease
Evaluation of [123I] MNI-308 and SPECT as a Marker of Beta-amyloid Protein Deposition in AD Subjects Compared to HC
The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I MNI-308, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT)…
- Trial name
- NCT00544453
- Testing
- [123I] MNI-308
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Alzheimer Disease, Mild Cognitive Impairment
Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges
The objectives of this study are to demonstrate the feasibility of implementing a deprescribing nudge intervention using pragmatic methods, confirm that outcomes can be feasibly measured and evaluated at scale in a subsequent…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06347172
- Testing
- Nudge Intervention
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2
The Diabetes and Aquatic Training Study (DATS)
This study evaluates the effects of the combined exercise training (aerobic more resistance) and of the aerobic exercise training isolated compared to control group, which performed only stretching and relaxation, in the…
- Trial name
- DATS (NCT02612805)
- Testing
- Aerobic training, Combined training
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Dementia, Alzheimer s Disease
Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker.
- Trial name
- BWIBS-WM (NCT07673770)
- Testing
- EEG-triggered TMS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Alzheimer's Disease and Related Dementia
Alzheimer's Disease and Related Dementias (ADRD) Prevalence in American Samoa
The goal of this study is to learn about ADRD prevalence within the Samoan population. Participants will be administered a series of cognitive assessments to determine cognitive status and a population-based prevalence of Mild…
- Trial name
- NCT05924529
- Where
- 2 sites in American Samoa
- Volunteers
- 1,098 people
- Sponsor
- American Samoa Community Cancer Coalition
Mild Cognitive Impairment, Alzheimer Disease
Retinal Neuro-vascular Coupling in Patients With Neurodegenerative Disease
Alzheimer´s disease (AD) in one of the most important causes of dementia and poses a considerable challenge in health care. Today, criteria for the diagnosis and the follow up of patients with AD mainly rely either on subjective…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Healthy
- Trial name
- NCT02663531
- Testing
- DVA, FDOCT, Pattern ERG
- Where
- Austria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hydration
Feasibility of Using the Gatorade Sports Science Institute (GSSI) Labs App for Hydration Related Outcomes
This remote study will evaluate the feasibility of using the Gatorade Sports Science Institute (GSSI) Labs App for remotely collecting hydration related outcomes.
- Trial name
- NCT07005895
- Testing
- Hydration assessment via mobile app
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Alzheimer Disease
Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease
The effects of the medication, memantine, on brain functions and the symptoms of Alzheimer's Disease will be tested
- Trial name
- NCT03703856
- Testing
- Memantine
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, San Diego
Dementia, Dementia Alzheimers
Implementation of a Diagnostic Decision-aid for People With Memory Complaints and Their General Practitioners
In a mixed-methods design the investigators will study decision making processes and experiences regarding a diagnostic trajectory before and after the introduction of a patient decision aid for people with memory complaints…
- Conditions
- Dementia, Dementia Alzheimers, Dementia, Mild
- Trial name
- S-DeciDeD (NCT04531956)
- Testing
- Diagnostic decision aid s-decided
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
The proposed study is designed to evaluate the performance of the ALTOIDA™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Disorders, Cognitive Impairment
- Trial name
- AltoidaML (NCT02843529)
- Testing
- Altoida: neuropsychological, MRI, EEG and CSF biomarkers
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Altoida
Alzheimer Disease
Alzheimer's Registry
The design is an open-ended, prospective, observational, (non-interventional) registry for subjects with mild cognitive impairment (MCI), early symptomatic Alzheimer's disease, Alzheimer's disease, or dementia with clinical…
- Trial name
- ALZ (NCT07420075)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- CorEvitas
Mild Cognitive Impairment
Study of Intravenous Immunoglobulin in Amnestic Mild Cognitive Impairment
Patients with mild cognitive impairment (MCI) are a group recognized at being at high risk of progressing to Alzheimer disease. Treatment of MCI with immunotherapy with intravenous immunoglobulins (IVIG) could potentially reduce…
- Trial name
- MCI (NCT01300728)
- Testing
- NewGam 10% IVIG
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Sutter Health
Genetic Risk for Alzheimer's Disease
Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease
This study examines the sensitivity of functional MRI to detect brain changes caused by donepezil HCL (a cholinesterase inhibitor) in healthy older adults at genetic risk for Alzheimer's Disease.
- Trial name
- NCT02087865
- Testing
- donepezil HCL
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Alzheimer Disease
Oral Semaglutide in Patients With Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease and a major global healthcare burden. Currently, the disease is only treated symptomatically and an effective disease-modifying therapy (DMT) that may slow the…
- Trial name
- NCT07200622
- Testing
- Semaglutide (Rybelsus®)
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Alzheimer Dementia, Parkinson Disease
Assessment of Empathetic Process by Scanpath Study of an Artwork
Analysis of gaze patterns during social cognition tasks and standardised exploration of a specific artwork, between elderly subjects without cognitive disorders and subjects with neurodegenerative diseases such as Fronto-Temporal…
- Conditions
- Alzheimer Dementia, Parkinson Disease, Fronto-Temporal Dementia
- Trial name
- EYE-EMPATH (NCT04665622)
- Testing
- Eye-Tracking / Neuropsychological evaluations
- Where
- Monaco
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Princesse Grace
Alzheimer's Disease
A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)
This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of crenezumab versus placebo in participants with prodromal to mild AD.
- Trial name
- CREAD 2 (NCT03114657)
- Testing
- Crenezumab
- Where
- 211 sites in United States, Argentina and 25 more
- Volunteers
- 806 people
- Sponsor
- Hoffmann-La Roche
Alzheimer's Disease
Study Evaluating the Safety, Tolerability and Efficacy of PBT2 in Patients With Early Alzheimer's Disease
The purpose of the study is to determine the safety, tolerability and efficacy of 2 doses of PBT2 administered for 12 weeks compared to placebo in patients with early Alzheimer's disease treated with an acetylcholinesterase…
- Trial name
- NCT00471211
- Testing
- PBT2
- Where
- 15 sites in Australia, Sweden
- Volunteers
- 80 people
- Sponsor
- Prana Biotechnology Limited
Abdominal Aortic Aneurysm
Evaluation of the Impact of Prehabilitation on Recovery Following Open Surgery for Abdominal Aortic Aneurysm
This is a pilot, prospective, randomized control trial that aim to provide a first estimation of the 3-month post-operative variation in the functional recovery of patients who benefited from an outpatient pre-habilitation…
- Trial name
- EPOP-AORTA (NCT05375292)
- Testing
- PREHABILITATION
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Dementia, Cognitive Impairment
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Our study intends to offer 'real world' evidence of a viable, sustainable means to mobilize primary care via a comprehensive strategy for detecting cognitive impairment and dementias, advancing next steps for referral, and…
- Conditions
- Dementia, Cognitive Impairment, Cognitive Decline, Alzheimer Disease
- Trial name
- NCT05607732
- Testing
- MyCog
- Where
- United States
- Volunteers
- 57,589 people
- Sponsor
- Northwestern University
Alzheimer´s Disease
EEG-cholinergic Index and Clinical Response to Treatment With Cholinesterase Inhibitors
Drug treatment with cholinesterase inhibitors is indicated for treatment of Alzheimer´s disease and in most cases, one of these drugs is prescribed as soon as the diagnosis has been made.
- Trial name
- Cholindex (NCT02623764)
- Volunteers
- 218 people
- Sponsor
- Landspitali University Hospital
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