Clinical trials: Alzheimer Dementia
Parkinson Disease, Alzheimer Disease
Application of AI Technology for the Diagnosis and Treatment of Geriatric Diseases
1) Characteristics of handwriting, gait, speech, eye movements, biological samples (blood, urine, stool, saliva, etc.), images, EEG, and other relevant markers in patients with Alzheimer's disease.
- Conditions
- Parkinson Disease, Alzheimer Disease, Nervous System Diseases, Geriatric Diseases
- Trial name
- NCT06295263
- Testing
- Handwriting, gait, speech, eye movements, biological samples (blood, urine, stool, saliva, etc.), images, EEG, and other relevant markers
- Where
- China
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Alzheimer Disease
ADDIA Chronobiological Study
The present single center clinical chronobiological study on 24 subjects (12 patients with mild to moderate form of Alzheimer's disease and 12 Healthy subjects) aims at characterizing the ADDIA biomarkers: a) blood cell-based…
- Trial name
- NCT02973971
- Testing
- volumeric MRI
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging
High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease
This completed randomized trial evaluated the clinical and neural effects of high-definition transcranial direct current stimulation (HD-tDCS) combined with computerized cognitive training in patients with Alzheimer's disease.
- Conditions
- Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging, Early Alzheimer's Disease
- Trial name
- HD-tDCS (NCT04599764)
- Testing
- HD-tDCS, computer-based cognitive training, Control cognitive training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Alzheimer Disease
Feasibility and Efficacy of the Ketogenic Diet in Alzheimer's Disease
The purpose of the KDRAFT study is to assess the feasibility and preliminary cognitive efficacy of a ketogenic diet therapy in patients with Alzheimer's disease.
- Trial name
- KDRAFT (NCT03690193)
- Testing
- Ketogenic Diet
- Volunteers
- 15 people
- Sponsor
- University of Kansas Medical Center
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimers Disease, Mild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor…
- Trial name
- NCT06484244
- Testing
- 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Alzheimer's Disease
Safety Study of PPI-1019 in Subjects With Mild-Moderate Alzheimer's Disease
This is a single-center, double-blind, inpatient study followed by an outpatient, placebo-controlled, multiple-IV injection evaluation of the safety and tolerability of PPI-1019 in subjects with mild-moderate Alzheimer's disease…
- Trial name
- NCT00100334
- Testing
- PPI-1019 (APAN)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- PRAECIS Pharmaceuticals Inc.
Depression
Prevention of Depression in Spouses of People With Cognitive Impairment
This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia.
- Trial name
- NCT00321971
- Testing
- PST-MCI/AD Caregiving, NT-MCI/AD Caregiving
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Individuals (Controls), Parkinson Disease
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases.
- Conditions
- Healthy Individuals (Controls), Parkinson Disease, Multiple Sclerosis, Alzheimer Disease
- Trial name
- Allena-mente (NCT07066137)
- Testing
- CAREN, Control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Dementia, Dementia Alzheimers
Implementing Dementia Care Management Into Routine Care in the Region Siegen-Wittgenstein
Dementia Care Management (DeCM) is an evidence-based model of care in Germany. It has proven its efficacy and cost-effectiveness. However it has not been implemented into routine care so far.
- Conditions
- Dementia, Dementia Alzheimers, Mild Cognitive Impairment, Care Management
- Trial name
- RoutineDeCM (NCT05529277)
- Testing
- Dementia Care Management
- Where
- 6 sites in Germany
- Volunteers
- 93 people
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Alzheimer Disease, Agitation,Psychomotor
Clinical Trial on Agitation in Alzheimer's Dementia
The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from…
- Conditions
- Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
- Trial name
- CALMA (NCT05543681)
- Testing
- IGC-AD1-Active
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 164 people
- Sponsor
- IGC Pharma, LLC
Down Syndrome, Alzheimer Disease
Vitamin E in Aging Persons With Down Syndrome
The goal of this study is to determine the safety and efficacy of the administration of vitamin E, which has been shown to delay the progression of Alzheimer's disease, in slowing the rate of cognitive/functional decline in older…
- Trial name
- NCT00056329
- Testing
- Vitamin E, multivitamin
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 350 people
- Sponsor
- New York State Institute for Basic Research
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Alzheimer's Disease
Study of Octagam (Intravenous Immunoglobulin [IVIG]) 10% on the Treatment of Mild to Moderate Alzheimer's Disease
This study evaluated the effect of 6 or 12 infusions of different doses of octagam (intravenous immunoglobulin [IVIG]) 10% on the reduction of amyloid beta peptide (Aβ) in cerebral spinal fluid (CSF) and on the increase of Aβ in…
- Trial name
- NCT00812565
- Testing
- octagam 10%
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Octapharma
Alzheimer's Disease
Lomecel-B Infusion Versus Placebo in Patients With Alzheimer's Disease
This is a Phase I, prospective, randomized, placebo-controlled, double-blinded study designed to test the safety and efficacy of LMSCs (Longeveron Mesenchymal Stem Cells) for the treatment of subjects with clinically diagnosed…
- Trial name
- NCT02600130
- Testing
- Longeveron Mesenchymal Stem Cells
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Longeveron Inc.
Dementia
Old SCHOOL Hip-Hop: Improve Alzheimer's Disease Knowledge
The purpose of this research study is to evaluate the knowledge of parents and children with respect to dementia symptoms, risk factors, and response before and after an interactive dementia education program that uses music and…
- Trial name
- NCT03284112
- Testing
- Old SCHOOL Hip-Hop, My Plate
- Where
- United States
- Volunteers
- 2,244 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alzheimer Dementia, Late Onset Alzheimer Disease
Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease
A phase 2, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety and efficacy of Allopregnanolone as a regenerative therapeutic for Alzheimer's disease.
- Conditions
- Alzheimer Dementia, Late Onset Alzheimer Disease, Neurodegenerative Diseases
- Trial name
- REGEN-BRAIN© (NCT04838301)
- Testing
- Allopregnanolone
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Alzheimer's Disease
Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of Age
The study determined the safety of CNP520 in healthy elderly over 3 months. Data relevant for Pharmacokinetic/Pharmacodynamic modeling were obtained in order to define the target dose in subsequent efficacy studies.
- Trial name
- NCT02576639
- Testing
- CNP520
- Where
- 11 sites in United States, Belgium and 3 more
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Alzheimer Disease
Alzheimer's Disease and Precision Medicine Research Among Native People
This project intends to address the gaps in Alzheimer's disease (AD) and precision medicine (PM) research in American Indian and Alaska Native (AI/AN) populations by comparing written and video-based materials for recruitment…
- Trial name
- NCT03448601
- Testing
- Culturally tailored brochure intervention group, Culturally tailored video intervention group
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease, Mild Cognitive Impairment
Adaptango Performance PRocess for Older Adults Community reHabilitation
This study is being done to answer the question: How do people with Parkinson's disease, people with Mild Cognitive Impairment, and younger people process difficult topics in conversation? It will also explore themes related to…
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
- Trial name
- APPROACH (NCT07824128)
- Testing
- Adaptango Performance Process (APP) program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
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