Clinical trials: Alzheimer Dementia
Stroke, Stroke, Acute
Impact of COVID-19 Vaccines on Cerebrovascular Health
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Dementia
- Trial name
- NCT04992195
- Testing
- Laboratory tests and Montreal Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Alzheimer's Disease
Screening and Evaluation of Patients With Signs and Symptoms of Alzheimer's Disease
Background: Individuals who demonstrate symptoms of Alzheimer s disease, such as progressive memory loss, may be eligible to participate in National Institutes of Health research studies.
- Trial name
- NCT00955422
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease
Digital Reminiscence Therapy for Alzheimer's in Institutionalized People
Digital reminiscence therapy (DRT) is an innovative intervention designed to enhance the psychological health of institutionalized seniors with Alzheimer's disease.
- Trial name
- NCT06666075
- Testing
- Digital and Interactive Reminiscence
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- University of Jaén
Breast Cancer, Colorectal Cancer
Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté
Medical progress and modification of lifestyles have prolonged life expectancy, despite the development of chronic diseases. The support and care are often provided by a network of informal caregivers composed of family, friends…
- Conditions
- Breast Cancer, Colorectal Cancer, Prostate Cancer, Alzheimer Disease
- Trial name
- ICE (NCT02626377)
- Testing
- Support provided by social worker, Information booklet receipt
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Alzheimer's Disease and Related Dementias
Reducing Behavioral and Psychological Symptoms of Dementia: Hospital Caregivers (Aim 2)
Persons with Alzheimer's Disease and Related Dementias (ADRD) account for 3.2 million hospital admissions per year and have over three times more hospitalizations than those without cognitive impairment, yet hospital caregivers…
- Trial name
- NCT04179721
- Testing
- PES-4-BPSD Model, The attention control condition
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Alzheimer Disease and Related Dementias (ADRD), Mild Cognitive Impairment (MCI)
Remote Sensing for ADRD-Specific Activities Identification in Older Adults
The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities among older adults, with the goal of early symptom…
- Trial name
- NCT07120347
- Testing
- Remote Ambient Sensor System
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Memory Disorders, Alzheimer's Disease
Amyloid Plaque and Tangle Imaging in Aging and Dementia
Amyloid senile plaques (SPs) and neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) that also accumulate in key brain regions in association with normal aging.
- Trial name
- NCT00355498
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
MCI
BRain Energy Activation With Ketones to Prevent Alzheimer's Disease
A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS).
- Trial name
- BREAK-AD (NCT04466735)
- Testing
- Active group
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Alzheimer's Disease, Aging
aeRobic Exercise and Cognitive Health
The purpose of the aeRobic Exercise and Cognitive Health (REACH) study is to understand how an aerobic exercise intervention might help promote brain health and cognition, thereby delaying the onset of clinical symptoms of…
- Trial name
- REACH (NCT02384993)
- Testing
- Enhanced Physical Activity
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease, Dementia
IONA Longitudinal Cohort Study
Understanding more about how diseases that cause dementia develop is critical as the number of people living with, or affected by, dementia in Scotland continues to grow.
- Trial name
- IONA LCS (NCT05892952)
- Where
- United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- Brain Health Scotland Life Sciences Ltd
Mild Cognitive Impairment Due to Alzheimer's Disease
AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease
The purpose of this study is to evaluate the effect of pioglitazone at 24 months compared with placebo on cognitive decline in high-risk participants who have completed the AD-4833/TOMM40_301 study [NCT01931566] with an…
- Trial name
- NCT02284906
- Testing
- Pioglitazone
- Where
- 43 sites in United States, Australia and 2 more
- Volunteers
- 40 people
- Sponsor
- Takeda
Alzheimer Disease, Dementia
Developing a Communication Intervention for People With Memory Challenges and Their Care Partners
The proposed research is consistent with broader public health goals focused on improving communication regarding end-of-life care and the Centers for Medicare and Medicaid Services' (CMS) call for increased patient engagement in…
- Trial name
- NCT05143255
- Testing
- KNOW
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Dementia of Alzheimer Type
CST-HK for Cognition and Well-being in People With Dementia
This cluster wait-list randomized controlled study investigates the effectiveness of Cognitive Stimulation Therapy (Hong Kong version) delivered by trained supportive staff and volunteers for people in maintaining the quality of…
- Trial name
- NCT05394584
- Testing
- Cognitive Stimulation Therapy
- Where
- Hong Kong
- Volunteers
- 129 people
- Sponsor
- The University of Hong Kong
Alzheimer's Disease
Multi-centre Study of HTL0018318 in Patients as an add-on to Standard-of-care
Multi-centre study of HTL0018318 in patients with Alzheimer's disease as an add-on to standard-of-care
- Trial name
- NCT03456349
- Testing
- HTL0018318
- Where
- 4 sites in Czechia, Poland and 2 more
- Volunteers
- 60 people
- Sponsor
- Nxera Pharma UK Limited
Alzheimer Disease, Dementia Disorder
The Protective Effect of Omega-3 Fatty Acid on Cognitive Function Among Patients With Mild Dementia
Background： Dementia is a progressive, devastating, and fatal neurodegenerative disorder. Alzheimer's disease (AD) is the most common cause of dementia, accounting for more than 50% of patients with dementia.
- Trial name
- NCT04972643
- Testing
- EPA, DHA
- Where
- Taiwan
- Volunteers
- 163 people
- Sponsor
- Taichung Veterans General Hospital
Alzheimer Disease, Alzheimer's Disease (Incl Subtypes)
Prediction of Amyloid and Mild Cognitive Impairment in Early Stage Alzheimer's Disease From Remote Speech Phenotyping
The S22 study investigates, in a cross-sectional study, the ability of algorithms that analyse acoustic and linguistic patterns of spoken language to predict the presence of amyloid positivity in early stage Alzheimer's disease…
- Conditions
- Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Mild Cognitive Impairment
- Trial name
- EARS (NCT04928690)
- Volunteers
- 140 people
- Sponsor
- Novoic Limited
Alzheimer's Disease
Normative Values for Cognitive Testing and Alzheimer's Imaging Biomarkers in Young Adults
Biomarkers of Alzheimer's disease (AD) occupy an essential place in recently formulated diagnostic criteria for AD where their role is to identify the pathophysiological processes underlying cognitive impairment or to predict…
- Trial name
- NCT01609335
- Testing
- F-18 FDG, C-11 PiB
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alzheimer Disease, Musculoskeletal Pain
At-Home Telehealth Yoga for Treating Chronic Pain in People With Alzheimer's Disease and Their Caregiver's
This feasibility study will evaluate yoga as a treatment for chronic pain in people living with Alzheimer's disease, and their Caregivers.
- Conditions
- Alzheimer Disease, Musculoskeletal Pain, Chronic Pain
- Trial name
- NCT04512040
- Testing
- At-Home Yoga
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Palo Alto Veterans Institute for Research
Alzheimer's Disease
The Safety and Efficacy of Neramexane in Patients With Moderate to Severe Alzheimer's Disease
Memory loss and difficulties with thinking associated with Alzheimer's disease may be due to chronic release of a brain chemical called glutamate.
- Trial name
- NCT00090116
- Testing
- Neramexane
- Where
- 34 sites in United States
- Volunteers
- 400 people
- Sponsor
- Forest Laboratories
Alzheimer Disease
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
This AR1001-ADP3-US01 protocol is a double-blind, randomized, placebo-controlled, multi- center, parallel-group comparison pivotal Phase 3 study to evaluate the efficacy and safety of AR1001 for the treatment of participants with…
- Trial name
- NCT05531526
- Testing
- AR1001
- Where
- 198 sites in United States, Canada and 11 more
- Volunteers
- 1,535 people
- Sponsor
- AriBio Co., Ltd.
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