Clinical trials: Alzheimer Dementia
Stroke
Clinical Effect Size of an Educational Intervention in the Home and Compliance on People Who Suffer From Stroke
Background. Cognitive, communication and physical weakness combined with environmental changes frequently cause changes in roles, routines and daily occupations.
- Trial name
- NCT01980641
- Testing
- Educational intervention, Smartphone-based application
- Where
- 2 sites in Spain
- Volunteers
- 34 people
- Sponsor
- University of Malaga
Alzheimer Disease
Improving Access to Care for Veterans With Memory Loss
This study evaluates a care delivery protocol to improve access to care for Veterans with Alzheimer's Disease and Related Disorders (ADRD).
- Trial name
- NCT07117162
- Testing
- ADRD Care Delivery Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Pittsburgh Healthcare System
Alzheimer Disease
A Study of LY3439539 in Participants With Alzheimer's Disease
The purpose of this study is to see how LY3439539 affects certain proteins found in the spinal fluid of participants with Alzheimer's disease.
- Trial name
- NCT07598370
- Testing
- LY3439539
- Where
- 15 sites in United States, Australia and 2 more
- Volunteers
- 30 people
- Sponsor
- Eli Lilly and Company
Obesity
Personalized Nutrition and eHealth: Lifestyle Intervention (LION) Study for Weight Loss Maintenance
Despite standardized intervention strategies, weight loss and weight loss maintenance largely differ from person to person. Factors which may contribute to these individual differences is current object of research.
- Trial name
- LION (NCT04023942)
- Testing
- Weight maintenance intervention
- Where
- Germany
- Volunteers
- 272 people
- Sponsor
- Technical University of Munich
Alzheimer Disease
Evaluation of 3APS in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this Phase III study is to evaluate the efficacy and safety of 3APS compared to placebo (inactive substance pill) in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00088673
- Testing
- 3APS
- Where
- 67 sites in United States, Canada
- Volunteers
- 950 people
- Sponsor
- Bellus Health Inc. - a GSK company
Alzheimer Disease
Dementia-specific Intervention of Advance Care Planning
This is a pilot study that aims to create a dementia-specific intervention of advance care planning (ACP) and test its feasibility and acceptance with min 20 max 30 patient-relative dyads.
- Trial name
- ADIA (NCT03615027)
- Testing
- Dementia-specific advance care planning
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Alzheimer's Disease
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
The purpose of this study is to: Evaluate the safety and tolerability of intrathecal (IT) ALN-5288 in patients with Alzheimer's Disease (AD) Evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ALN-5288 after…
- Trial name
- NCT07214727
- Testing
- ALN-5288
- Where
- 13 sites in Canada, Netherlands and 2 more
- Volunteers
- 50 people
- Sponsor
- Alnylam Pharmaceuticals
Major Depressive Disorder
Pathophysiology of Neurodegeneration in Late-life Depression (AV45+THK)
Late-life depression has been frequently associated with cognitive impairment. Several meta-analyses consistently suggested that a history of depression approximately doubles an individual's risk for developing dementia later in…
- Trial name
- NCT03430869
- Testing
- F-18 AV-45, F-18-THK-5351
- Where
- Taiwan
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer Disease
Pharmacokinetics of Tricaprilin Including Food Effect on Ketone Body Production
This is a Phase I, single center, open label, fixed-order, crossover, food-effect, pharmacokinetic (PK) study recruiting healthy, adult, male subjects.
- Trial name
- NCT03551769
- Testing
- tricaprilin, standard meal, high-fat meal
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cerecin
Alzheimer Disease
Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab versus placebo in participants with early (prodromal to mild) AD.
- Trial name
- NCT03444870
- Testing
- Gantenerumab
- Where
- 172 sites in United States, Australia and 13 more
- Volunteers
- 1,053 people
- Sponsor
- Hoffmann-La Roche
Insomnia, Sleep Initiation and Maintenance Disorders
Modafinil Treatment for Sleep/Wake Disturbances in Older Adults
Modafinil, trade named Provigil, is a medication approved by the Food and Drug Administration for the treatment of narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder.
- Conditions
- Insomnia, Sleep Initiation and Maintenance Disorders, Alzheimer Disease
- Trial name
- NCT00626210
- Testing
- modafinil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Palo Alto Health Care System
Alzheimer Disease
A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease
The purpose of this study is to assess the safety, tolerability and effect of study drug LY3372689 in participants with early symptomatic Alzheimer's Disease
- Trial name
- NCT05063539
- Testing
- LY3372689
- Where
- 69 sites in United States, Australia and 3 more
- Volunteers
- 327 people
- Sponsor
- Eli Lilly and Company
Mild to Moderate Alzheimer's Disease
4 Week, Safety and Tolerability Study in Patients With Mild to Moderate Alzheimer's Disease
The primary purpose of the study is to determine the safety and tolerability of AZD1446 vs Placebo given as an add-on treatment to Donepezil for 4 weeks in patients with mild to moderate Alzheimer's disease.
- Trial name
- ROBIN (NCT01039701)
- Testing
- AZD1446
- Where
- 12 sites in Czechia, Hungary and 1 more
- Volunteers
- 99 people
- Sponsor
- AstraZeneca
Alzheimer's Disease
Project TAP: Tailored Activities Project
Specific Aims 1. Establish a preliminary effect size for the impact of the intervention on depressive affect and agitated behaviors in persons with dementia in 4 months 2.
- Trial name
- NCT00259467
- Testing
- Home-Based Behavorial Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Dementia, Alzheimer Disease, Pain
Pain Management and Behavioral Outcomes in Patients With Dementia
Dementia illness often co-exists with painful medical conditions associated with aging (e.g., degenerative joint disease, osteoarthritis, skin ulcers, back pain, headaches, cancer, or angina).
- Conditions
- Dementia, Alzheimer Disease, Pain, Behavior, Agitation
- Trial name
- NCT00012857
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- US Department of Veterans Affairs
Alzheimer's Disease
Development of Multimodal Fusion Warning System and Non-invasive Techniques for Early Alzheimer's Detection.
Developing and validating an early digitalized recognition device and multimodal warning model for Alzheimer's disease, and establishing a precision transcranial ultrasound stimulation intervention system.
- Trial name
- NCT05978830
- Testing
- Transcranial ultrasound stimulation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Advance Care Planning
Advance Care Planning in Cognitive Disorders Clinic
Advance care planning among patients with cognitive disorders poses unique challenges to clinicians. To improve planning in patients with Alzheimer's disease and other dementias, the researchers suggest a routine, standardized…
- Trial name
- NCT03864965
- Testing
- Advance Care Planning
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of Florida
Alzheimer Disease
Digital Technology Combined With Blood Marker Screening and Diagnosis for Community Populations Based on Classification Theory: an Integrated Study
Our research hypothesis is as follows: A step - by - step screening strategy based on screening technologies can resolve the issue of insufficient efficiency in the traditional scale - based screening model.
- Trial name
- NCT07286812
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Alzheimer Disease, Caregiver Burden
Swallowing Impairments in Adults With and Without Alzheimer's Disease
This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers.
- Conditions
- Alzheimer Disease, Caregiver Burden, Healthy Aging, Dysphagia
- Trial name
- NCT06678100
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cognitive Impairment
Ascending Dose Study of CT1812 in Healthy Volunteers
This is a double-blind, placebo controlled, ascending dose, multi-cohort trial. The study will be conducted in two phases: a single ascending dose (SAD) phase "Part A", followed by a multiple ascending dose (MAD) phase "Part B".
- Trial name
- NCT02570997
- Testing
- CT1812
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cognition Therapeutics
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