Clinical trials: Alzheimer Dementia
Alzheimer Disease
Clinical Study Evaluating Efficacy and Safety of T3D-959 in Mild-to-moderate AD Subjects
A Randomized, Double-Blind, Placebo-Controlled Multi-Center Study to Evaluate the Safety and Efficacy of Three Dose Strengths of T3D-959 in Subjects with Mild-to-Moderate Alzheimer's Disease.
- Trial name
- NCT04251182
- Testing
- 15mg T3D-959, 30 mg T3D-959, 45 mg T3D-959
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- T3D Therapeutics, Inc.
Alzheimer Disease
Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease
To examine the differences in the capacity to activate microglia in patients with Alzheimer's Disease (AD) compared to age-comparable cognitively normal subjects and younger healthy controls.
- Trial name
- NCT04057807
- Testing
- LPS
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Yale University
Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD)
Expanding Access to Cognitive Health Biomarker Testing at Home
The goal of this observational study is to learn whether at-home blood biomarker testing for Alzheimer's disease risk is feasible and acceptable in older adults with cognitive concerns.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD), Subjective Cognitive Decline (SCD), Cognitive Aging
- Trial name
- NCT07594665
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Diabetes, Alzheimer's Disease (Incl Subtypes)
Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes
The goal of this study is to test CGM ASSIST. This is a digital tool that uses an interactive information display-an easy-to-read screen designed to help people with dementia (or memory loss) and diabetes, as well as their…
- Conditions
- Diabetes, Alzheimer's Disease (Incl Subtypes), Dementia, Hypoglycemia
- Trial name
- CGM ASSIST (NCT05643144)
- Testing
- Continuous Glucose Monitoring
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Dementia
Telephone Support for Dementia Caregivers
Caring for a patient with dementia is associated with increased feelings of burden and depression. The proposed study will examine the efficacy of Family Intervention: Telephone Tracking - Dementia (FITT-Dementia), a…
- Trial name
- NCT00735800
- Testing
- Family Intervention:Telephone Tracking Support- Caregiver, Telephone Support
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rhode Island Hospital
Parkinson Disease
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's Disease
The purpose of this study is to determine the safety, tolerability and blood levels of orally administered anle138b as well as the effect of food and early signs of efficacy in patients with mild to moderate Parkinson´s disease.
- Trial name
- NCT04685265
- Testing
- anle138b
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- MODAG GmbH
Alzheimer's Disease
Transcranial Photobiomodulation (tPBM) in Alzheimer's Disease Study
The purpose of this study is to see if a special light treatment, called photobiomodulation, can help people with memory problems such as Mild Cognitive Impairment or Mild Dementia due to Alzheimer's disease.
- Trial name
- NCT07224607
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Cedars-Sinai Medical Center
Alzheimer Disease
Imaging Biomarkers in Preclinical and Symptomatic AD
The purpose of this research study is to evaluate adult children of parents with and without Alzheimer's disease which represent an ideal population for investigating the biological changes that precede the clinical onset of AD.
- Trial name
- ACS_PIB_IND (NCT04134923)
- Testing
- [11C] Pittsburgh Compound-B (PIB)
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Tammie L. S. Benzinger, MD, PhD
Prevention
Management of Dementia With Olive Oil Leaves - GOLDEN
Mild Dementia (Mild Dementia) is a state of mind disorder (memory, reason, attention, concentration, time orientation) with difficulty in the complex activities of everyday life (bank accounts, shopping, transportation, etc).The…
- Trial name
- GOLDEN (NCT04440020)
- Testing
- Beverage of Olive Oil Leaves, Mediterranean Diet
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Alzheimer's Dementia With Behavioral Disturbance
Acupuncture to Reduce Anxiety in Alzheimer's Disease (AD) and AD Related Dementias
The purpose of this study is to investigate the influence of acupuncture on heart rate variability, skin conductance (sweating), and rated behavioral expression of agitation, irritability, and anxiety and mood in qualifying…
- Trial name
- NCT03814382
- Testing
- Acupuncture needle
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease
A Phase 1, Two-part, Randomized Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a Liquid Formulation of Tricaprilin and Matching Placebo in Healthy Subjects
The purpose of this study is to evaluate the PK, safety, and tolerability of a new liquid formulation of tricaprilin.
- Trial name
- NCT05408780
- Testing
- AC-OLE-01-VA
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cerecin
Alzheimer Disease
Insulin, Neurogenetics and Memory in Alzheimer's Disease
This study examines the use of insulin-sensitizing compounds, as therapeutic agents for cognitive impairment in Alzheimer's disease.
- Trial name
- NCT00018382
- Testing
- rosiglitazone
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Dementia Alzheimers
ImGTS for Patients With Behavioral and Psychological Symptoms of Dementia
The proposed research project aims to answer the question "Are immersive technology systems effective in the management and treatment of patients with BPSD?".
- Trial name
- NCT05265182
- Testing
- virtual reality
- Where
- Philippines
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augmented eXperience E-health Laboratory
Alzheimer Disease
Clinical Trial to Evaluate the Efficacy and Safety of GV1001 in Alzheimer Patients
This clinical study is designed as a multi-center, randomized, double-blind, placebo-controlled, parallel design, prospective, phase II clinical trial.
- Trial name
- NCT03184467
- Testing
- Normal Saline 0.9%, GV1001 0.56 mg, GV1001 1.12 mg
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- GemVax & Kael
Skin Lesion, Traumatic Ulcer
Clinical Investigation EUCLIDES-01 for the Calculation of the Area of Skin Lesions
The aim of this clinical investigation is to collect skin lesion area data for the comparison of the agreement among the results obtained between the following three wound area measurement methods: Ruler using the Kundin method…
- Conditions
- Skin Lesion, Traumatic Ulcer, Hematoma, Pressure Ulcer
- Trial name
- NCT05729334
- Testing
- Clinicgram Euclides
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Skilled Skin S.L.
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Alzheimer's Disease Agitation
This trial was a multi-center, double-blind, placebo-controlled, randomized study to evaluate the efficacy and safety of AXS-05 compared to placebo for the treatment of agitation associated with Alzheimer's disease.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation
- Trial name
- ADVANCE-2 (NCT05557409)
- Testing
- AXS-05
- Where
- 55 sites in United States, Puerto Rico
- Volunteers
- 408 people
- Sponsor
- Axsome Therapeutics, Inc.
Alzheimer Disease, Behavior Disorders
Impact and Influence of the Use of Hypnosis Adapted to People With Severe Stage Neurocognitive Disorder (HAPNeSS) on the Professional Practices of EHPAD (Establishment for Dependent Elderly People) Caregivers With Elderly Residents
The aim of this study is to propose a non-anxiety-inducing method of managing behavioral disorders for patients and healthcare professionals.
- Trial name
- HAPNeSS-E (NCT06535763)
- Testing
- professional caregiver
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Anosognosia, Alzheimer's Disease
Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and the William. S. Middleton VA Hospital.
- Conditions
- Anosognosia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT00908999
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer's Disease
European Study of 3APS in Mild to Moderate Alzheimer's Disease Patients
The purpose of this Phase 3 study is to evaluate the efficacy and safety of 3APS as an add-on therapy to most standard medication for Alzheimer's disease compared to placebo (inactive substance pill) in patients with mild to…
- Trial name
- NCT00217763
- Testing
- 3APS
- Where
- 69 sites in Belgium, France and 8 more
- Volunteers
- 930 people
- Sponsor
- Bellus Health Inc. - a GSK company
Alzheimer Disease, Mild Dementia
Acute Effect of Low-intensity Gamma rTMS on Cognitive and EEG Parameters in Adults With Mild Dementia by Alzheimer's Disease
Neurocognitive disorders have a growing prevalence and impact on public health; their main etiology corresponds to Alzheimer's disease. To date, there is no treatment that can reverse neuronal damage in these pathologies.
- Trial name
- NCT05784298
- Testing
- low-intensity rTMS
- Where
- Mexico
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
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