Clinical trials: Alzheimer Dementia
Alzheimer Disease
MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease
This study is a phase 2a randomized double-blind, placebo-controlled, study, in mild-to-moderate Alzheimer's disease, of the oral investigational drug MW150, a p38alphaMAPK kinase inhibitor.
- Trial name
- SKI-AD (NCT05194163)
- Testing
- MW150
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Neurokine Therapeutics
Subjective Cognitive Decline, Preclinical Alzheimer's Disease
Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD
This study is affiliated to Sino Longitudinal Study on Cognitive Decline, SILCODE. To establish models of normal and pathological cognitive aging.To collect the longitudinal data of SCD population, to study the dynamic changes of…
- Trial name
- NCT03370744
- Testing
- Neuropsychological scale
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- XuanwuH 2
Mild Cognitive Impairment (MCI), Mild Alzheimer Disease
Efficacy and Safety of Photobiomodulation Therapy in Patients With Mild Cognitive Impairment and Mild Alzheimer's Disease
The goal of this clinical trial is to learn if photobiomodulation therapy (PBMT) can help treat mild cognitive impairment and mild Alzheimer's disease in adults aged 50 to 85 years. It will also learn about the safety of PBMT.
- Conditions
- Mild Cognitive Impairment (MCI), Mild Alzheimer Disease, Dementia
- Trial name
- PBMT in MCI (NCT07835399)
- Testing
- Photobiomodulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jun Xu
Alzheimers' Disease
Cognitive Behavioural Therapy for Persons With MCI or Mild Dementia
A total of 200 home dwelling participants, who fulfil the inclusion criteria, Alzheimer's disease, will be recruited from three hospitals in Norway.
- Trial name
- NCT02013518
- Testing
- Cognitive Behavioural Therapy
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Dementia, Alzheimer's Disease
"Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program"
A Pilot Study for the Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia program (HALT-AD). This initial four-months pilot study will focus on at least three educational courses (introduction to…
- Conditions
- Dementia, Alzheimer's Disease, Dementia Prevention
- Trial name
- HALT-AD (NCT05350410)
- Testing
- HALT-AD
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Mild Cognitive Impairment, Dementia
Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)
The purpose of this research is to investigate the long-term effectiveness and safety of new Alzheimer's disease treatments, particularly monoclonal antibody therapies like lecanemab and donanemab, as well as to enhance…
- Conditions
- Mild Cognitive Impairment, Dementia, Subjective Cognitive Decline (SCD), Alzheimer Disease
- Trial name
- JOY-ALZ (NCT06889818)
- Where
- 3 sites in South Korea
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alzheimer Disease, Dementia
Periodontitis and Periodontal Bacteria in Dementia
The study is designed to inquire whether the presence of periodontitis and different periodontopathogenic bacterial strains are associated with dementia diagnosis and with the degree of cognitive impairment in participants…
- Conditions
- Alzheimer Disease, Dementia, Periodontitis
- Trial name
- NCT05557617
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Örebro County
Alzheimer Disease
LatAm-FINGERS Initiative for Cognitive Change
Currently, 40% of global dementia cases can be prevented through lifestyle changes, with Latin America having a 56% potential reduction due to its high-risk factors.
- Trial name
- LatAmFINGERS (NCT06492967)
- Testing
- Systematic Lifestyle Intervention, Flexible Lifestyle Intervention
- Where
- 13 sites in Argentina, Bolivia and 10 more
- Volunteers
- 1,065 people
- Sponsor
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
COVID-19
Phase I/II Clinical Trial of Recombinant Novel Coronavirus (COVID-19) Vaccine (Adenovirus Type 5 Vector) for Inhalation
This study is a randomized, double-blind, placebo-controlled I/II clinical trial, in order to evaluate the safety and immunogenicity of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) for Inhalation in adults 18…
- Trial name
- NCT04840992
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) for Inhalation, Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- Where
- China
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Alzheimer Disease, Early Onset Alzheimer Disease
Gene Therapy for APOE4 Homozygote of Alzheimer's Disease
This clinical trial is an open label, dose-ranging study designed to evaluate gene therapy to treat patients who are APOE4 homozygotes with clinical diagnosis varying from mild cognitive impairment due to Alzheimer's, mild…
- Trial name
- NCT03634007
- Testing
- LX1001
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Lexeo Therapeutics
Sleep Disturbance, Amnestic Mild Cognitive Impairment
Sleep Interventions and Neurocognitive Outcomes
This protocol focuses on the effect of sleep interventions on improving sleep and building cognitive/brain resilience in older adults with amnestic mild cognitive impairment and sleep disturbance.
- Trial name
- SINA (NCT05987007)
- Testing
- Acoustic slow-wave activity enhancement, Cognitive behavioral therapy for insomnia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer's Disease
Memantine for Agitation and Aggression in Severe Alzheimer's Disease
Alzheimer's disease (AD) is the most common form of dementia and is characterized by both cognitive and behavioural symptoms ("Behavioural and Psychological Symptoms of Dementia"; BPSD).
- Trial name
- NCT00401167
- Testing
- memantine
- Where
- 2 sites in Canada
- Volunteers
- 31 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer's Disease
Randomized, Double-blind Study to Evaluate the Tolerability of 2 Different Titration Methods of Rivastigmine Patch in AD Patients (MMSE 10-20)
To evaluate the tolerability, safety and efficacy of 3-step titration versus 1-step titration of Rivastigmine patch in the Japanese population.
- Trial name
- NCT01614886
- Testing
- Active Comparator, ENA713
- Where
- 50 sites in Japan
- Volunteers
- 216 people
- Sponsor
- Novartis Pharmaceuticals
Alzheimer Disease, Dementia
Improving PCP Advance Care Planning for People With ADRD
This study will test the Dementia Advance Care Planning (AD ACP) Toolkit intervention to usual care in facilitating goals of care (GOC) discussions between People Living with Dementia (PLwD) and primary care team members over an…
- Conditions
- Alzheimer Disease, Dementia, Alzheimer's Disease (Incl Subtypes), Aging
- Trial name
- AD-ACP (NCT06565169)
- Testing
- Primary Care Team Advance Care Planning With People with Alzheimer's Disease or a Related Dementia Training, Care as Usual
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Pittsburgh
Alzheimer's Disease (AD)
Radiolabeled TSPO Targeted Molecular Probe in Alzheimer's Disease.
Evaluate the clinical application value of the novel radiolabeled TSPO-targeted molecular probe Gallium [68Ga]-DOTA-HK-011 in neuroinflammation imaging of Alzheimer's disease.
- Trial name
- NCT07105956
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Fall, Alzheimer Disease
Falls: A Marker of Preclinical AD
This longitudinal cohort study investigates cognitively normal participants with and without preclinical Alzheimer disease (AD) in order to examine: (1) the relationship between falls and functional mobility in preclinical stages…
- Trial name
- NCT04949529
- Where
- United States
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alzheimer's Disease
Single Ascending Dose Study of BIIB037 in Participants With Alzheimer's Disease
The primary objective of the study is to evaluate the safety and tolerability of a range of BIIB037 doses administered as single intravenous (IV) infusions in participants with mild to moderate Alzheimer's Disease (AD).
- Trial name
- NCT01397539
- Testing
- BIIB037
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Biogen
Alzheimer Disease
A Long-Term Safety And Tolerability Extension Study Of Bapineuzumab In Alzheimer Disease Patients
The purpose of this study is to assess the long-term safety and tolerability of bapineuzumab in subjects with Alzheimer Disease who participated in study 3133K1-3001(NCT00676143).
- Trial name
- NCT00998764
- Testing
- Bapineuzumab 0.5 mg/kg
- Where
- 184 sites in United States, Argentina and 17 more
- Volunteers
- 494 people
- Sponsor
- Pfizer
Apathy, Alzheimer's Disease
Apathy in Dementia Methylphenidate Trial 2
Apathy in Dementia Methylphenidate Trial 2 (ADMET 2) is a Phase III, placebo-controlled, masked, 6 month, multi-center randomized clinical trial sponsored by National Institutes of Aging involving 200 participants with…
- Trial name
- ADMET2 (NCT02346201)
- Testing
- Methylphenidate
- Where
- 10 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
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