Clinical trials: Alzheimers Disease
Alzheimer Disease
Efficacy and Safety of Curcumin Formulation in Alzheimer's Disease
Curcumin is shown to impact several different pathways of neuroprotection, however clinical trials have not shown positive results, due to the poor bioavailability of curcumin.
- Trial name
- NCT01001637
- Testing
- Curcumin Formulation
- Where
- India
- Volunteers
- 26 people
- Sponsor
- Jaslok Hospital and Research Centre
Alzheimer Disease
Imaging Inflammation in Alzheimer's Disease With 11C-ER176
This study is being done to learn about inflammation in the brain of those with Alzheimer's disease (AD). The purpose of this study is to determine if 11C-ER176 is able to accurately measure inflammation in patients with…
- Trial name
- NCT03744312
- Testing
- 11C-ER176, Florbetaben
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alzheimer's Disease
Study of Octagam (Intravenous Immunoglobulin [IVIG]) 10% on the Treatment of Mild to Moderate Alzheimer's Disease
This study evaluated the effect of 6 or 12 infusions of different doses of octagam (intravenous immunoglobulin [IVIG]) 10% on the reduction of amyloid beta peptide (Aβ) in cerebral spinal fluid (CSF) and on the increase of Aβ in…
- Trial name
- NCT00812565
- Testing
- octagam 10%
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Octapharma
Cognitively Normal, Mild Cognitive Impairment
Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease
The overall goal of this imaging trial is to evaluate crosssectional difference and longitudinal changes of [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in cognitively normal individuals, and…
- Conditions
- Cognitively Normal, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03903211
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jae Seung Kim
Alzheimer Disease, Presbycusis
Clinical Trial on Alzheimer Disease, Presbycusis and Hearing Aids
This is a 12-months' randomized clinical trial that aims at studying the benefit of bilateral hearing aids in hearing impaired patients suffering from a slight to moderate stage Alzheimer disease.
- Trial name
- NCT00488007
- Testing
- Hearing aids used : PHONAK Savia and Valeo
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Hospices Civils de Lyon
Alzheimer Disease
AC-OLE-01-VA Tolerability Study in Healthy Participants Under Different Dosing Conditions
This is an open-label, 3-arm study to compare tolerability of three different titration and dosing schedules of the AC-OLE-01-VA formulation of tricaprilin.
- Trial name
- NCT05628636
- Testing
- AC-OLE-01-VA
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cerecin
Dementia, Alzheimer's Disease
Virtual Reality Intervention for the Reduction of Behavioral and Psychological Symptoms of Dementia
Alzheimer's disease and related disorders (AD2) are characterised by cognitive changes and Behavioural and Psychological Symptoms of Dementia (BPSD).
- Conditions
- Dementia, Alzheimer's Disease, Neurocognitive Disorders
- Trial name
- LUMEENCOMPAD (NCT04769024)
- Testing
- LUMEEN Virtual Reality sessions, Control/non-digital stimulation sessions
- Where
- 6 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Healthy
Study Of Single Ascending And Multiple Doses Of PF-04447943 In Japanese Subjects.
This study is designed to investigate the safety, tolerability, and pharmacokinetics of PF-04447943 after single and multiple-dose administration to healthy young adult and elderly Japanese subjects, respectively.
- Trial name
- NCT00959803
- Testing
- PF-04447943
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alzheimer's Disease, Dementia
A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Patients With Hallucinations and Delusions Associated With Alzheimer's Disease
The purpose of this study is to assess the effectiveness and safety of risperidone (an antipsychotic medication) versus placebo for the treatment of patients with hallucinations and delusions associated with Alzheimer's disease.
- Trial name
- NCT00287742
- Testing
- risperidone
- Volunteers
- 33 people
- Sponsor
- Janssen Pharmaceutical K.K.
Alzheimer Disease
Estrogen Hormone Protocol
Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen.
- Trial name
- NCT00000177
- Testing
- Estrogen
- Where
- 25 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Aging (NIA)
Alzheimer's Disease
To Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease
With the enrichment of living environment and the progress of medicine, the scale of aging population has increased in many countries of the world.
- Trial name
- NCT03656042
- Testing
- Filgrastim (75mcg/0.3ml)
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer Disease, Dementia
Detecting Probable Alzheimer's Disease From Speech Using Linguistical Analysis
The object of this study is to investigate the use of linguistic deficits from speech samples for the early detection of Mild Cognitive Impairment and probable Alzheimer's disease.
- Trial name
- NCT04041895
- Testing
- Audio speech recording
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- East Tennessee State University
Mild Cognitive Impairment, Alzheimer Disease
ALSENLITE: Senolytics for Alzheimer's Disease
This study is being done to evaluate the safety and feasibility of using Dasatinib and Quercetin together in subjects with Mild Cognitive Impairment (MCI) or Alzheimer's disease.
- Trial name
- NCT04785300
- Testing
- Dasatinib, Quercetin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Transcranial Magnetic Stimulation, Alzheimer Disease
Cerebellar ITBS Mode Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease
Study the therapeutic effect and potential neural mechanisms of cerebellar iTBS mode transcranial magnetic stimulation on Alzheimer's disease patients through MRI and EEG.
- Conditions
- Transcranial Magnetic Stimulation, Alzheimer Disease, Magnetic Resonance Imaging, Electroencephalogram
- Trial name
- NCT06379100
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Alzheimer Disease
Study Evaluating the Safety of Lecozotan SR in Healthy Young and Elderly Subjects
To assess the safety, tolerability and pharmacokinetics of single and multiple ascending oral doses of lecozotan SR in healthy young and elderly subjects.
- Trial name
- NCT00366483
- Testing
- Lecozotan SR
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Alzheimer Disease
Non-invasive Stimulation Through Nesa and Therapeutic Exercise on Sleep Disturbances on Alzheimer's Disease Patients.
The purpose of this study is to know the effectiveness of an adapted therapeutic exercise program and its comparison with non-invasive neuromodulation through the NESA device, and both treatments with a control group, to improve…
- Trial name
- NCT05715866
- Testing
- non-invasive neuromodulation through the Nesa device, therapeutic exercise, sleep hygiene measures
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Murcia
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety…
- Trial name
- NCT04771845
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 73 people
- Sponsor
- The New York Memory Services
Delirium, Anticholinergic Adverse Reaction
Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:
Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects.
- Conditions
- Delirium, Anticholinergic Adverse Reaction, Alzheimer Disease
- Trial name
- NCT05055895
- Testing
- Anticholinergic burden
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- Gulhane Training and Research Hospital
Alzheimer Disease, Mild Cognitive Impairment
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
There is a major unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and dementia.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognitive Decline
- Trial name
- QUIP II (NCT06025877)
- Testing
- PrecivityAD2(TM) blood test
- Where
- 9 sites in United States
- Volunteers
- 400 people
- Sponsor
- C2N Diagnostics
Alzheimer's Disease, Transcranial Magnetic Stimulation
Safty and Efficacy of MCI Network Guided TMS for Early Alzheimer's Disease: A Randomized, Double-blind Trial
Estimate the safty and efficacy of personalized network neuronavigated transcranial magnetic stimulations in early Alzheimer's disease patients
- Conditions
- Alzheimer's Disease, Transcranial Magnetic Stimulation, Individualized Navigation
- Trial name
- SENS-eAD (NCT07138677)
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University