Clinical trials: Ambulation Disorder, Neurologic
Stroke Rehabilitation, Stroke Rehabilitation Spasticity Management
Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot
Clinical randomized clinical trial to assess the effectiveness on walking speed of repeated use of botulinum neurotoxin type A (BoNT/A)in the post-stroke spastic equinovarus foot in three successive infiltrations at 6-month…
- Trial name
- NCT03044080
- Testing
- IncobotulinumtoxinA, OnabotulinumtoxinA
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Parc de Salut Mar
Stroke
Weight-bearing Training in Stroke Patients.
1. Are there differences in weight-bearing (WB) and WB symmetry immediately following STS and stepping training with or without using external feedback in ambulatory patients with stroke? 1.
- Trial name
- NCT04192240
- Testing
- WB Training with external feedback, WB Training without external feedback
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Rett Syndrome
Open Label Trial of Triheptanoin (UX007) in Treatment of Rett Syndrome.
This is a single-center, exploratory, open-label study in 10 girls diagnosed with Rett Syndrome. The study will consist of the following 4 parts: Screening/Baseline run-in, Titration/Dose-Setting, Treatment, and Washout/Follow-up.
- Trial name
- UX007 (NCT03059160)
- Testing
- Tridecanoic Acid
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis
Remote Exercise Effects on Cognitive Processing Speed in Multiple Sclerosis: A Pilot Trial
Cognitive processing speed (CPS) impairment is prevalent, impactful, and poorly-managed in multiple sclerosis (MS). Upwards of 67% of patients present with MS-related CPS impairment, which is associated with poor everyday life…
- Trial name
- REACT-MS (NCT05344040)
- Testing
- Remotely Delivered and Supported Aerobic Walking Exercise Training, Remotely Delivered and Supported Stretching and Toning Exercise Training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kessler Foundation
Stroke
Impaired Interlimb Coordination During Locomotion in Individuals With Chronic Stroke: Contributors and Effect on Walking Function
Individuals with chronic stroke have long-term walking problems that limit community engagement and quality of life, lead to secondary disabilities, and increase healthcare costs and burden.
- Trial name
- NCT07006818
- Testing
- Direct current stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Spinal Cord Injury, Paralysis
Restoration of Standing and Walking With ISMS in Humans
Spinal cord neural circuitry exists in the lumbar enlargement that makes it possible to stand and create synergistic, rhythmic stepping activity in the lower limbs.
- Trial name
- ISMS (NCT02899858)
- Testing
- Movement Assessment, MRI Scan, IntraSpinal Micro-Stimulation
- Where
- United States
- Sponsor
- Vanderbilt University
Spinal Cord Injuries, Gait Disorders, Neurologic
Safety and Feasibility of TWIICE Rise
The aim of this study is to assess the safety and the feasibility of two versions of TWIICE Rise for exoskeleton-assisted ambulation in patients with a spinal cord injury.
- Trial name
- NCT05926310
- Testing
- TWIICE Rise
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- TWIICE
Spinal Cord Injury (SCI), Gait
Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)
The purpose of this study is to evaluate the safety, feasibility, and preliminary effectiveness of the ReWire system, which delivers vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve gait in…
- Conditions
- Spinal Cord Injury (SCI), Gait, Reduced Physical Activity, Lower Limb Functions
- Trial name
- NCT07689227
- Testing
- CLV
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Parkinson's Disease Patients
Bio-Feedback to Improving Stability in Elderly Population
Our hypothesis is that intensive training with positive biofeedback may enhance postural control and stability in Parkinson's disease patients and in elderly fallers.
- Trial name
- NCT00716261
- Testing
- McROB Hybrid node 3-axes accelerometers and 3-axes gyroscopes
- Where
- Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center
Transplant-Related Disorder, Frail Elderly Syndrome
Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients
The objective of this study is to assess the feasibility and effectiveness of dedicated ambulator-assisted physical activity in lung transplant inpatients.
- Conditions
- Transplant-Related Disorder, Frail Elderly Syndrome, Sarcopenia, Lung Graft Dysfunction
- Trial name
- iFRAIL (NCT03636412)
- Testing
- Ambulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Pain, Hypoxia
Effects of Walking Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158282
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Ischemic Stroke
Gait Recovery in Patients After Acute Ischemic Stroke
More than 80% of ischemic stroke (IS) patients have some walking disability, which restricts their independence in the activities of daily living.
- Trial name
- GAITFAST (NCT04824482)
- Testing
- Robot-assisted treadmill gait training (RTGT), Therapist-assisted treadmill gait training (TTGT)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Olomouc
Morton Neuroma, Pes Planus
Comparison of the Effects of Morton's Neuroma on Foot Pressure Distribution and Gait Parameters in Pes Planus and Pes Cavus Patients
The aim of our study is to compare the effect of Morton's neuroma in feet with pes planus and pes cavus on foot pressure and temporal and spatial gait parameters.
- Conditions
- Morton Neuroma, Pes Planus, Pes Cavus
- Trial name
- NCT05012488
- Testing
- Comparison of gait and foot pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Acibadem University
Stroke
Cortical Activation During Walking in Stroke
After stroke, damage to one cerebral hemisphere disrupts the normal balance of activity between the two hemispheres. The affected hemisphere typically exhibits reduced excitability, whereas the unaffected side may demonstrate…
- Trial name
- NCT06840405
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Yang Ming Chiao Tung University
Cerebrovascular Disease; Sequelae
Machines Assisting Recovery From Stroke
Locomotor disability remains a major obstacle to community function in stroke survivors. This disability is best characterized by the reduced gait speed and enhanced risk of falls that is observed in the majority of stroke…
- Trial name
- MARS (NCT02787694)
- Testing
- Factor Targeted Walking Training, treadmill
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injury
Non-Ambulatory SCI Walk Using a Robotic Exoskeleton: Effect on Bone and Muscle
The purpose of this research study is to evaluate an exoskeleton device and mobility skills in the device.
- Trial name
- NCT02324322
- Testing
- Exoskeleton Training, Muscle Biopsies, MRI
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Figure of 8 Walk Test in Multiple Sclerosis
Balance disorder is common in people with MS. As the disease worsens, it is associated with impaired balance, difficulty walking, decreased mobility, and an increased risk of falling.
- Trial name
- NCT05433714
- Testing
- Assesment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Cerebral Palsy
Effect of Designed Physical Training After Selective Dorsal Rhizotomy on Motor Function of Ambulant Children With Spastic Diplegia
The management of cerebral palsy is complex and requires a multidisciplinary approach. Selective dorsal rhizotomy is a neurosurgical technique that aims to reduce spasticity in the lower limbs and improve motor function.
- Trial name
- NCT04997044
- Testing
- Concomitant physical rehabilitation, Standard Orthotic Management, selective dorsal rhizotomy
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Stroke, Cognitive Impairment
Combining Cognitive and Treadmill Training on Cognition and Walking Performance in Stroke With Cognitive Impairment
Post-stroke cognitive impairment is common in stroke survivors. Cognitive function is related to walking ability. The dual task walking is required for daily activities, however, such ability is even more challenging than single…
- Trial name
- NCT04545138
- Testing
- cognitive training combine treadmill training, Treadmill training
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Yang Ming Chiao Tung University
Sarcopenia in Elderly
The Effect of Adding Elastic Resistance Training in Routine Physical Exercise on Walking Speed of Elderly People With Sarcopenia in Griya Wreda Jambangan, Surabaya
The goal of this randomized clinical trial is to learn whether adding elastic resistance training (ERT) to routine physical exercise can improve walking speed in older adults aged 60 years or older with sarcopenia living at Griya…
- Trial name
- NCT07859969
- Testing
- Elastic Resistance Training, Routine Physical Exercise
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
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