Clinical trials: Ambulation Disorder, Neurologic
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323698
- Testing
- Caffeine, AIH
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Musculoskeletal Pain
A Proactive Walking Trial to Reduce Pain in Black Veterans
The long term goal is to improve the quality and equity of chronic pain treatment among VA patients. The primary objective of this study is to improve pain outcomes among black VA patients with chronic, musculoskeletal (MSK)…
- Trial name
- ACTION (NCT01983228)
- Testing
- Intervention Condition
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- VA Office of Research and Development
Orthostatic Hypotension, Parkinson's Disease
A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease
This is a study to evaluate the effects of an investigational drug, Droxidopa, in participants with neurogenic orthostatic hypotension (NOH), associated with Parkinson's disease.
- Trial name
- 306A/306B (NCT01176240)
- Testing
- Droxidopa
- Where
- 60 sites in United States
- Volunteers
- 225 people
- Sponsor
- Chelsea Therapeutics
Parkinson Disease, Brain Stimulation
Cerebellar Transcranial Direct Current Stimulation in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects approximately 1 million people in the United States with total annual costs approaching 11 billion dollars.
- Conditions
- Parkinson Disease, Brain Stimulation, Cerebellum
- Trial name
- NCT04046055
- Testing
- Transcranial direct current stimulation at 2 mA, Transcranial direct current stimulation at 4 mA
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Thorsten Rudroff
Stroke
Rehabilitating Corticospinal Control of Walking
The VHA estimates that over 15,000 Veterans incur a stroke each year. As the population of older Veterans grows, stroke will become an increasingly important problem to the VHA.
- Trial name
- ABC of Walking (NCT02132650)
- Testing
- ACC training, SS training
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Cerebral Palsy
Effect of Dysport Injections on Energy Expenditure and Walking Efficiency in Children With Cerebral Palsy
This study aims to evaluate the efficacy of single event multi level chemoneurolysis with the abobotulinumtoxin A drug, Dysport®, on walking energy expenditure and gait in children with spastic diplegia cerebral palsy.
- Trial name
- NCT03469999
- Testing
- Dysport Injectable Product
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Cerebral Palsy
Testing an Adjustable Ankle Orthosis During Walking in Cerebral Palsy
This study seeks to determine how an adjustable stiffness ankle braces affects walking performance and biomechanics in cerebral palsy.
- Trial name
- NCT06262191
- Testing
- Differential and adjustable stiffness AFO (DAS-AFO)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northern Arizona University
Spinal Cord Injury
Neuromodulation Techniques After SCI
Spinal cord injury (SCI) leads to several health-related consequences often linked to reduced levels of physical activity. Direct stimulation of the spinal cord, either through implanted devices or surface stimulation, has been…
- Trial name
- NCT04241250
- Testing
- EAW+SCES (exoskelton and spinal cord epidural stimulation), EAW+TS (exoskelton and transspinal stimulation)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Sensorimotor Gait Disorder, Neurologic Ambulation Disorder
Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop
The objective of this study is to determine the effectiveness of the NESS L300 (L300) in improving gait parameters, function, and quality of life among stroke subjects (greater than or equal to 3 months post stroke)with drop foot.
- Conditions
- Sensorimotor Gait Disorder, Neurologic Ambulation Disorder, Gait, Drop Foot, Poststroke Hemiparesis
- Trial name
- L300 (NCT01138995)
- Testing
- Ness L300, Ankle-foot orthosis
- Where
- 11 sites in United States
- Volunteers
- 197 people
- Sponsor
- Bioness Inc
Spinal Cord Injuries
Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury
The purpose of this study is to collect data comparing two means of providing locomotor training: manual and robotic and the possible differential effects it may have on walking ability for persons with spinal cord injury (SCI).
- Trial name
- DE (NCT00127439)
- Testing
- Manually Assisted Locomotor Training, Robotic Assisted Locomotor Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
HIV, AIDS
Lower Extremity Splinting to Manage Pain and Sleep Disturbances Associated With HIV/AIDS Related Peripheral Neuropathy
WHAT IS THE PURPOSE OF THIS STUDY? The investigators want to know if wearing a pair of splints at night works to bring the pain down and help you sleep better (in people living with HIV/AIDS related neuropathy).
- Conditions
- HIV, AIDS, Peripheral Neuropathy, Pain
- Trial name
- NCT01419314
- Testing
- Splinting application to the lower extremities, Splint liner application
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Texas Woman's University
Stroke
Combined Cognitive and Gait Training
Recent research in gait training for stroke survivors showed that coordinated gait components can be best restored using the following interventions together: coordination exercises, over ground gait training, and body weight…
- Trial name
- CogGait (NCT02362282)
- Testing
- Gait training, cognitive training, Arm training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury
The purpose of this pilot study is to investigate whether gait specific robotic supported bodyweight supported treadmill training and lower extremity strength training have similar beneficial effects on walking function and other…
- Trial name
- NCT01087918
- Testing
- RAGT, Strength Training
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Stroke
Walk Assist Device to Improve Community Ambulation
The goal of this research study was to examine the immediate effects of a prototype wearable robotic stride management assist device (SMA) designed by Honda R\&D® on clinical walking performance, walking energetics, gait…
- Trial name
- NCT03222505
- Testing
- Honda Stride Assist Device ON, No Device Worn
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shirley Ryan AbilityLab
Chronic Diseases, Obesity
Home-Based Exercise and Weight Control Program for Pain Control in Overweight Elderly With Osteoarthritis of the Knee
The purpose of this study is to determine whether a home-based exercise and weight control program applied to elderly overweight individuals with painful osteoarthritis of the knee, would result in pain reduction.
- Conditions
- Chronic Diseases, Obesity, Osteoarthritis, Pain
- Trial name
- NCT00126737
- Testing
- Weight Control Nutritional Program, Home-based exercise program
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- US Department of Veterans Affairs
Cerebrovascular Disease; Sequelae
Machines Assisting Recovery From Stroke
Locomotor disability remains a major obstacle to community function in stroke survivors. This disability is best characterized by the reduced gait speed and enhanced risk of falls that is observed in the majority of stroke…
- Trial name
- MARS (NCT02787694)
- Testing
- Factor Targeted Walking Training, treadmill
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Down Syndrome
Treadmill Training and Orthotic Use in Infants With Down Syndrome
This study determines the effect of orthotic use in combination with treadmill training on the development of gross motor skills and walking onset in infants with Down syndrome.
- Trial name
- NCT00825175
- Testing
- Treadmill Training, Supramalleolar Orthoses
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
Stroke
Characteristics of Balance Control to Unexpected Loss of Balance During Standing and Walking in Post-stroke Individuals
aim: To examine the effect of a perturbation-based balance training on balance reaction characteristics in post stroke individuals.
- Trial name
- NCT02619175
- Testing
- Stroke Subjects Perturbation-Based Balance Training, Stroke Subjects Weight Shifting and Gait training
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nachum Soroker, MD
Spinal Cord Injuries, Brown Sequard
Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury
Change to Reflect What Was Done and reason Changes Were Made. The purpose of this study is to determine (1) if a specific breathing treatment (intermittent hypoxia) can promote changes in breathing function and (2) if pairing…
- Conditions
- Spinal Cord Injuries, Brown Sequard, Central Cord Syndrome
- Trial name
- NCT01272011
- Testing
- Intermittent Hypoxia, Locomotor Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development