Clinical trials: Amino Acid Metabolism
Amino Acids, Essential, Metabolism
Impact of Amino Acids to Enhance Anabolism After Home-based Exercise
An adequate quantity of lean body mass is vital for optimal health and performance, and is accrued when net protein balance (NPB) is positive.
- Conditions
- Amino Acids, Essential, Metabolism, Exercise
- Trial name
- B2B (NCT04850820)
- Testing
- Novel essential amino acid supplementation, Branched-chain amino acid supplementation (BCAA), Isocaloric carbohydrate supplementation
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Phenylketonuria (PKU)
A Study of MZE782 in Adults With PKU
The purpose of this study is to evaluate the safety, tolerability, and efficacy of MZE782 in adults with Phenylketonuria (PKU).
- Trial name
- CIPheR (NCT07694440)
- Testing
- MZE782
- Where
- 9 sites in United States, France and 1 more
- Volunteers
- 38 people
- Sponsor
- Maze Therapeutics
Homocystinuria
Betaine METABOLISM OF PATIENTS With Homocystinuria
Oral treatment with betaine is conventionally used for patients with inherited homocystinurias. These conditions include a first group of patients with a cystathionine β-synthase (CBS) deficiency and a second group of patients…
- Trial name
- HCTBETAINE (NCT02404337)
- Testing
- Betaine
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Phenylketonuria (PKU)
Simple Breath Test to Examine Phenylalanine Metabolism
Phenylketonuria(PKU)is a rare condition caused by the body's inability to properly breakdown an amino acid called phenylalanine(PHE), due to a missing enzyme, phenylalanine hydroxylase(PAH).
- Trial name
- NCT02009904
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Amino Acid Metabolism, Inborn Errors
Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders
OBJECTIVES: I. Assess the safety and efficacy of sodium phenylbutyrate, sodium benzoate, sodium phenylacetate, and dietary intervention in patients with urea cycle disorders.
- Trial name
- NCT00004767
- Testing
- Sodium Benzoate, Sodium Phenylacetate, Sodium Phenylbutyrate
- Volunteers
- 20 people
- Sponsor
- National Center for Research Resources (NCRR)
Pre Diabetes
Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes
Higher than average blood sugar (glucose) levels are linked to an increased risk of developing type 2 diabetes. As such, there is interest in identifying dietary factors that could lower blood glucose to help reduce the number of…
- Trial name
- Whey2Glo (NCT03785951)
- Testing
- Whey Protein Isolate, Wheat Protein, Wheat Protein with Leucine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Non-Alcoholic Fatty Liver Disease, Obesity
Direct Versus Indirect Effect of Amino Acids on Hepatokines
Liver hormones are key metabolic regulators and increased in metabolic diseases, including fatty liver disease. The underlying mechanisms driving the elevated levels are currently unknown and presents a major challenge in…
- Trial name
- Diaakine (NCT06240039)
- Testing
- Evaluating the acute effect of an amino acid infusion with and without a concomitant infusion of the somatostatin analogue octreotide to eliminate endogenous production of glucagon
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Tryptophan Metabolism in Healthy Young Adults
Tryptophan is an essential amino acid needed for growth and bodily functions. It is used to make serotonin which is needed for the brain to develop and function properly.
- Trial name
- NCT06551545
- Testing
- Tryptophan intake
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
CBS Deficiency
Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria
In homocystinuria due to cystathionine beta synthase (CBS) deficiency or classical homocystinuria, decreased blood cysteine levels are observed.
- Trial name
- NCT04015557
- Testing
- Acetaminophen, N-acetylcysteine
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
End Stage Renal Disease, Hyperhomocysteinemia
Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis
OBJECTIVES: I. Compare the efficacy of two doses of folic acid in normalizing plasma total homocysteine concentration in patients with end stage renal disease receiving regular hemodialysis therapy resulting in…
- Trial name
- NCT00004495
- Testing
- cyanocobalamin, folic acid, pyridoxine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Georgetown University
Schizophrenia, Psychotic Disorders
Acute Glycine Pharmacodynamic Study
The purpose of this study is to use proton magnetic resonance spectroscopy (MRS) at 4 Tesla to measure brain glycine levels noninvasively at baseline and for 2 hours after a single oral dose of a concentrated glycine-containing…
- Trial name
- NCT01610011
- Testing
- Glycine administration
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Type 2 Diabetes, Prediabetes
Effects of an Amino Acid and Chromium-picolinate Containing Drink on Glucose Metabolism
It has previously been shown in healthy overweight subjects, that table water including a defined amount of amino acids and chromium can decrease the postprandial glucose and insulin response.
- Trial name
- NCT02235194
- Testing
- Amino Acid and chromium-picolinate containing drink
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Ornithine Transcarbamylase Deficiency
A Study to Assess Plasma Ammonia Time-Normalized Area Under the Curve and Rate of Ureagenesis in Healthy Adult Subjects
The objective of the study is to characterize 24-hour plasma ammonia levels, characterize urea production rates in healthy normal subjects.
- Trial name
- NCT04269122
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ultragenyx Pharmaceutical Inc
Protein Deficiency
Comparison of Meal Replacements Versus Protein Supplements and Utilizing the Protein Digestibility Corrected Amino Acid Score (PDCAAS) Method
The purpose of this research study is to compare the varying qualities of protein supplements utilizing the Protein Digestibility Corrected Amino Acid Score (PDCAAS) method and evaluating the clinical outcome related to protein…
- Trial name
- PDCAAS (NCT01399333)
- Testing
- Group 1 Meal Replacement, Group 2 Protein Supplement, Group 3
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southeast Bariatrics, PA
Sepsis
Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis
The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.
- Trial name
- NCT06258252
- Testing
- Effect of BCAAs metabolic dysfunction on cardiac function in sepsis
- Volunteers
- 50 people
- Sponsor
- West China Hospital
Healthy Men
Metabolic Availability of Lysine From Millet in Adult Men
Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins.
- Trial name
- NCT03339167
- Testing
- Metabolic availability of lysine in millet
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Brain Neoplasm, Neoplasm Metastasis
Gene Therapy for the Treatment of Brain Tumors
Malignant brain tumors are responsible for a significant amount of deaths in children and adults. Even with advances in surgery, radiation therapy, and chemotherapy, many patients diagnosed with a malignant brain tumor survive…
- Trial name
- NCT00001328
- Testing
- Cytovene (Ganciclovir Sodium), G1TKSVNa.53 Producer Cell Line
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
The Impact of Protein Intake on Protein Metabolism During Intensified Training
Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).
- Trial name
- NCT02801344
- Testing
- Normal, Moderate, High
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Homocystinuria
A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)
The goal of this long-term extension (LTE) study is to evaluate the safety and efficacy of pegtibatinase in patients with classical homocystinuria (HCU).
- Trial name
- ENSEMBLE (NCT06431893)
- Testing
- Pegtibatinase
- Where
- 52 sites in United States, Australia and 12 more
- Volunteers
- 100 people
- Sponsor
- Travere Therapeutics, Inc.
Type I Diabetes Mellitus
Glutamine and Insulin Sensitivity in Type I Diabetes
Insulin is crucial to help the body metabolize ('burn') sugar (glucose). Even though juvenile (type 1) diabetes (T1D) is primarily due to the lack of insulin, patients with T1D tend to become less sensitive to insulin…
- Trial name
- NCT01467063
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Nemours Children's Clinic