Clinical trials: Amino Acid Metabolism
Hereditary Tyrosinemia, Type I
Bioavailability Food-Effect Study of an Oral Nitisinone Formulation to Treat Hereditary Tyrosinemia (HT-1)
The purpose of this study is to compare the bioavailability of the Test Product, Nitisinone 10 mg Tablet, under fasting and fed conditions (food-effect).
- Trial name
- NCT02750332
- Testing
- Nitisinone
- Where
- South Africa
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cycle Pharmaceuticals Ltd.
Phenylketonuria (PKU)
PANDA: PKU Amino Acid Evaluation
Phenylketonuria (PKU) is a rare inherited metabolic disorder, where subjects are born with a genetic deficiency in the phenylalanine hydroxylase enzyme (PAH), which leaves them unable to convert Phenylalanine (Phe) into Tyrosine…
- Trial name
- PANDA (NCT04086511)
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 37 people
- Sponsor
- Nutricia Research
Phenylketonuria
Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Subjects With Phenylketonuria
This is an open-label, non-comparative, Phase 3 study to evaluate the degree, frequency of response and safety of Kuvan® (sapropterin dihydrochloride) in subjects aged 4 to 18 years who have phenylketonuria and with elevated…
- Trial name
- NCT01732471
- Testing
- Kuvan®
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Phenylketonurias
Effects of Synergy on Nutrient Intake and Acceptability in Phenylketonuria (PKU)
Phenylketonuria (PKU) is a rare inherited metabolic disorder, where subjects are born with a genetic deficiency in the phenylalanine hydroxylase enzyme (PAH), which leaves them unable to convert Phenylalanine (Phe) into Tyrosine…
- Trial name
- ESSENTIAL (NCT03777826)
- Testing
- PKU Synergy
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 13 people
- Sponsor
- Nutricia Research
Phenylketonuria (PKU)
Evaluation of BH4 Responsiveness in Our PKU Patients
This study aims to evaluate BH4 responsiveness in our PKU patients and to correlate BH4 responsiveness with their genotype
- Trial name
- NCT07255599
- Testing
- Sapropterin Dihydrochloride (BH4, tetrahydrobiopterin)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Obesity, Morbid
Amino Acid Metabolism Before and After Bariatric Surgery
This observational study aims to investigate the changes in serum amino acid metabolism before and after bariatric surgery in obese individuals.
- Trial name
- NCT07008352
- Testing
- Blood sample collection for amino acid profiling
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Harran University
Healthy Adults
Metabolic Availability of Lysine From White Maize
Our objective is to determine the metabolic availability of Lysine in white maize using the indicator amino acid oxidation (IAAO) technique in adult men.
- Trial name
- NCT02018575
- Testing
- Crystalline Lysine Amino Acid Mix, White corn meal porridge
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Hepatocellular Carcinoma, Cirrhosis
Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer death among men. While several new treatment options have recently become available, they are costly and have a potential for significant, adverse side…
- Conditions
- Hepatocellular Carcinoma, Cirrhosis, Liver Failure
- Trial name
- BCAA in HCC (NCT03908255)
- Testing
- Branch Chain Amino Acid, maltodextrin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Amino Acid Deficiency, Malnutrition
Effect of Compound Amino Acid Tablets on Nutritional Status of Patients With Lung Cancer
To investigate whether compound amino acid supplementation can further promote protein synthesis and improve nutritional status for lung cancer patients.
- Conditions
- Amino Acid Deficiency, Malnutrition, Lung Cancer
- Trial name
- NCT05770063
- Testing
- amino acid tablet
- Volunteers
- 86 people
- Sponsor
- Beijing Chest Hospital
Chediak-Higashi Syndrome
Study of Chediak-Higashi Syndrome
Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized in its classical form by oculocutaneous albinism, a bleeding diathesis, recurrent infection due to abnormal neutrophil and natural killer cell…
- Trial name
- NCT00005917
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Urea Cycle Disorders, Crigler Najjar Syndrome
Long-term Safety Follow-up Study of Patients Having Received HepaStem (SAF001)
The purpose of this study is to assess the long-term safety follow-up of patients having been treated with HepaStem.
- Trial name
- NCT02051049
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Cellaion SA
Propionic Acidemia
Review of Charts From Amish/Mennonite Variant PA Patients
The natural history of patients with PA-AMV has not been systematically studied before and there is no published data in the literature about this condition since 1980.
- Trial name
- NCT03159026
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Pittsburgh
Sports Injury
Clinical Trial for Vespa Amino Acid Mixture (VAAM®)
ATP is generated mainly through anaerobic metabolism during strenuous exercise, which is then followed by the generation of lactic acid.
- Trial name
- NCT03121040
- Testing
- Vespa amino acid mixture
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanghai Meiji Health Science and Technology Co., Ltd.
Phenylketonurias
The Effects of CGMP in Children and Adults With PKU
Randomised controlled trial with a crossover design. For early and continuously treated patients with phenylketonuria (PKU) that are adherent.
- Trial name
- ELEMENT (NCT04076176)
- Testing
- CGMP protein substitute, L-amino acid protein substitute
- Where
- 3 sites in Denmark, United Kingdom
- Volunteers
- 12 people
- Sponsor
- Vitaflo International, Ltd
Muscle Strength, Vitamin B 12 Deficiency
Study of the Association of Muscle Strength, Balance and Other Factors With Vitamin Levels Among Elderly Diabetics
Vitamin B12 deficiency can cause severe problems with the blood, nerves, brain and psychological well-being. Ironically, our modern methods for the control of diabetes mellitus can actually contribute to vitamin B12 deficiency.
- Conditions
- Muscle Strength, Vitamin B 12 Deficiency, Folate Deficiency, Vitamin D Deficiency
- Trial name
- NCT03376490
- Where
- Singapore
- Volunteers
- 56 people
- Sponsor
- SingHealth Polyclinics
Disaster, Vulnerable Populations
Korean Translation and Validation of the K-HEPI in NYC
Nurses Taking on Readiness Measures (N-TORM) is an innovative nurse-driven household emergency preparedness intervention modeled after an existing community intervention provided by emergency management personnel.
- Trial name
- NCT05544578
- Testing
- Nurses Taking On Readiness Measures (N- TORM)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Phenylketonuria, Behavior and Behavior Mechanisms
Evaluation of Behavior, Executive Function, Neurotransmitter Function and Genomic Expression Kuvan Nonresponders
This observational study seeks to establish evidence: 1. that physiologic changes, unrelated to effect on the Phenylalanine Hydroxylase (PAH) enzyme, occur in Phenylketonuria (PKU) patients who are treated with sapropterin…
- Conditions
- Phenylketonuria, Behavior and Behavior Mechanisms, PAH Gene Expression
- Trial name
- IST (NCT01274026)
- Testing
- sapropterin dihydrochloride
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Medicine
Postprandial Hyperglycemia, Metabolic Syndrome
Effects of a Carbonated Water Enriched With Amino Acids and Chromium Picolinate (Good Idea®) on Glucose Homeostasis.
It has previously been shown in healthy subjects, that a carbonated water containing a mix of amino acids and chromium picolinate can decrease postprandial blood glucose.
- Conditions
- Postprandial Hyperglycemia, Metabolic Syndrome, Type 2 Diabetes Mellitus
- Trial name
- NCT03552315
- Testing
- Carbonated water with amino acids and chromium
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Obesity & Overweight
Effect of a Food for Special Medical Purposes on Muscle Mass Preservation During GLP-1 RAs Weight Loss Treatment
This study evaluates whether a Food for Special Medical Purposes (FSMP) can help to preserve appendicular skeletal muscle mass (ASMM) in adults undergoing weight loss treatment with GLP-1 receptor agonists or dual GIP/GLP-1…
- Trial name
- MYO-PRESERVE (NCT07393360)
- Testing
- Myosave®
- Where
- 3 sites in Italy
- Volunteers
- 144 people
- Sponsor
- Pharmanutra S.p.a.
Piebaldism, Segmental Vitiligo
Autologous Cell Suspension Grafting Using ReCell in Vitiligo and Piebaldism Patients
Autologous epidermal cell suspension grafting is an effective method of surgical treatment in vitiligo, which is suitable for treating larger areas with better cosmetic results as compared to other grafting methods.
- Trial name
- NCT01640678
- Testing
- ReCell epidermal cell suspension grafting, CO2 laser abrasion + UV-therapy
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)