Clinical trials: Amino Acids
Hypercholesterolemia, Cognitive Dysfunction
The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions
The study evaluates if the relationship between total serum cholesterol is dependent on the total serum homocysteine. Fasting blood samples will taken from participants and two batteries of cognitive scales will be used to asses…
- Conditions
- Hypercholesterolemia, Cognitive Dysfunction, Hyperhomocysteinemia
- Trial name
- NCT03631238
- Testing
- Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.
- Where
- Egypt
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arginase I Deficiency, Hyperargininemia
A Study of AEB1102 (Pegzilarginase) in Patients With Arginase 1 Deficiency
The purpose of this study is to determine the safety, tolerability, and efficacy of long-term intravenous and subcutaneous administration of pegzilarginase for the treatment of pediatric and adult patients with ARG1-D who…
- Trial name
- NCT03378531
- Testing
- AEB1102
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 14 people
- Sponsor
- Immedica Pharma AB
Response of Fatty Acid Desaturation to Zinc Intake
A Comparison of the Metabolic Effects of Zinc-Amino Acid (ZnAA) Versus Zinc Gluconate
Food consumption affects zinc metabolism within the body. Lowe and colleagues demonstrated that zinc is directed out of plasma and into tissues, such as into the liver, postprandially .
- Trial name
- NCT06348056
- Testing
- 30 mg Zn Amino Acid daily for 13 days, 30 mg Zn Gluconate daily for 13 days
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Muscle Strength, Athletic Performance
HME Amino Acid Supplementation for Strength, Performance, and Recovery in Trained Adult Males
This pilot randomized controlled trial evaluates HME (Human Muscle Equivalent), a free-form amino acid supplement formulated to match the amino acid composition of human skeletal muscle, taken at its Health Canada licensed dose…
- Conditions
- Muscle Strength, Athletic Performance, Resistance Training
- Trial name
- NCT07715201
- Testing
- HME (Human Muscle Equivalent)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Orivian inc
Muscle Protein Synthesis, Whole-body Protein Balance
Essential Amino Acids and Protein Kinetics During Caloric Deprivation
The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined.
- Trial name
- NCT03372928
- Testing
- Standard EAA, High EAA
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Optical Coherence Tomography (OCT) of the Retina
Low Cost OCT for Point of Care
The purpose of this study is to compare the performance of a prototype optical coherence tomography (OCT) machine with currently available high resolution OCT machines.
- Trial name
- NCT03323307
- Testing
- OCT imaging
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Duke University
Malnutrition Elderly, Protein Malnutrition
The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults
The goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (ProSauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein…
- Trial name
- ProSauce (NCT06965699)
- Testing
- ProSauce, low-protein sauce
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Obesity, Type 2 Diabetes
Adaptive Mechanisms In GRown up ObeSity Study (AMIGROS)
The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes.
- Trial name
- AMIGROS (NCT06065930)
- Testing
- Subcutaneous microdialysis
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
To Assess the Safety and Tolerabiltiy of an Amino Acid Composition in Subjects With Sickle Cell Disease, Anemia, Sickle Cell
To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell Disease
This is an open-label study to understand the safety and tolerability of AXA4010, a novel composition of amino acids in adult and adolescent subjects with sickle cell disease over 12 weeks.
- Conditions
- To Assess the Safety and Tolerabiltiy of an Amino Acid Composition in Subjects With Sickle Cell Disease, Anemia, Sickle Cell, Sickle Cell Anemia, Sickle Cell Disorders
- Trial name
- NCT04134299
- Testing
- AXA4010
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Axcella Health, Inc
Hepatic Encephalopathy
Plasma Free Amino Acids in Patients With Hepatic Encephalopathy
This is study to investigate the plasma free amino acids profile in patients with decompensated liver cirrhosis and hepatic encephalopathy and its relation to the nutritional state of these patients.
- Trial name
- NCT03306498
- Testing
- Aminoleban (8% amino acids infusion)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Endothelial Dysfunction, Hyperhomocysteinemia
Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian Individuals
The present study aims at investigating the effects of the oral supplementation with creatine on the systemic microvascular reactivity and plasma levels of homocysteine in vegetarian individuals of the vegan type.
- Trial name
- NCT02961972
- Testing
- monohydrate and micronized creatine
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Old Age
Modulation of Muscle Protein Metabolism by Essential Amino Acids
The investigators plan to explore the ability of amino acids, the building blocks of proteins in our bodies and in the food we eat, to stimulate muscles to grow and stay strong.
- Trial name
- Aj1B (NCT01890369)
- Testing
- 15g Mixed Essential Amino Acids, 3g Leucine, 15g Mixed Essential Amino Acid REFEED
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Urea Cycle Disorders
Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders
In proximal urea cycle disorders (UCD), particularly ornithine transcarbamylase deficiency (OTCD), hyperammonemia (HA) causes increased brain glutamine (Gln) which perturbation is thought to be at the core of the neurological…
- Trial name
- UCD (NCT02935283)
- Testing
- MRI, Behavioral
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Healthy Women of Child Bearing Potential
Metabolic Availability of Methionine in Tempeh Chips Among Reproductive-age Women Using Indicator Amino Acid Oxidation (IAAO) Method
The goal of this study is to determine the protein quality of soybean tempeh in the form of chips. The main objective of this study is to determine how much methionine in tempeh can be used by reproductive-age women using the…
- Trial name
- IAAO (NCT07251842)
- Testing
- dietary intakes, Dietary intake
- Where
- Malaysia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Rotator Cuff/Shoulder Structure and Function
Nutritional Supplementation Effects on Rehabilitation Outcomes in Rotator Cuff Pathology
Rotator Injury: Strength/range of Motion ASES, VAS
- Trial name
- NCT01798693
- Testing
- Multi-nutrient Blend
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Aging
Effects of Age on Amino Acid Delivery to Tendon
Dietary amino acid supplementation may provide an effective means to promote tendon injury recovery and enhance collagen synthesis.
- Trial name
- NCT04064528
- Testing
- Amino Acids
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Vitamin B6 Deficiency
Vitamin B6 Dependence of One-Carbon Metabolism
Marginal vitamin B6 deficiency, which occurs commonly worldwide, leads to a cellular deficiency of the coenzyme pyridoxal phosphate (PLP).
- Trial name
- NCT00877812
- Testing
- Arm 1 glycine and leucine, Arm 2 Intervention of Serine and methionine infusion
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Metastatic Colorectal Cancer
Study of Glutamine as Prophylaxis for Irinotecan Induced Diarrhea
Irinotecan (7-ethyl-10- {4(-1-piperidino)-1-piperidino} carbonyloxy camptothecin) is a semisynthetic camptothecin derivative introduced in the 1980's.
- Trial name
- NCT00255229
- Testing
- Glutamine
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- AHS Cancer Control Alberta
Skeletal Muscle
Leucine or Protein Supplementation and Resistance Training
The purpose of this study was to determine the effects of L-leucine (LEU) or different protein supplements standardized to LEU (~3.0 g/serving) on changes in body composition, strength, and histological attributes in skeletal…
- Trial name
- MPS (NCT03501628)
- Testing
- L-leucine + maltodextrin, Whey protein concentrate, Hydrolyzed whey protein concentrate
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Auburn University
Cow Milk Allergy
Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides
The main aim of this study is to provide longitudinal growth data in infants with moderate-to-severe cow's milk allergy fed an amino acid-based formula with two added human milk oligosaccharides.
- Trial name
- PLATYPUS (NCT03661736)
- Testing
- Food for Specific Medical Purpose
- Where
- Australia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
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