Clinical trials: Amino Acids
Advanced Gastrointestinal Cancers
Lymphocyte Enhancement in Gastroenteric Oncology
LEGO is single center double-blind randomized trial aimed at testing the efficacy of an essential ammino acid (EAA) supplementation in improving the absolute count of peripheral lymphocytes and the tolerance to chemotherapy in…
- Trial name
- NCT06343272
- Testing
- EAA supplementation
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Protein Metabolism
Effect of Microbial Protease Supplementation on Postprandial Amino Acid Levels
Dietary protein is digested in the stomach and intestines to smaller peptides and 20 individual amino acids which, when absorbed by the gut into circulation and taken up by skeletal muscle, help stimulate muscle protein synthesis…
- Trial name
- NCT04821557
- Testing
- Protease + Protein
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Phenylketonuria (PKU)
Impact of Phenylketonuria-type Diet on Appetite, Appetite Hormones and Diet Induced Thermogenesis
Low-phenylalanine diets are commonly prescribed to people with phenylketonuria (PKU), an inborn disease which causes accumulation of amino acid phenylalanine (Phe) in the blood.
- Trial name
- NCT02440932
- Testing
- Phenylketonuria-type diet, Normal (control) diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Food Allergy in Children, Cow Milk Allergy
Nutrition Sufficiency, Allergy Efficacy and Safety of Neocate Jr in Children With Food Protein Allergy
The main purpose of this study is to evaluate efficacy and safety of an amino acid-based formula Neocate Jr in children with food protein allergy, and to evaluate nutrition sufficiency of Neocate Jr in 1 to 10 years old children…
- Trial name
- NCT05406141
- Testing
- Amino acid formula (Neocate Jr)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Cardiovascular Risk Factor, Obesity
Essential Amino Acids and High Intensity Interval Training
Purpose: The primary purpose is to determine the combined effects of essential amino acids (EAA) supplementation and high intensity interval training (HIIT) on body composition, muscle characteristics, and muscle architecture in…
- Trial name
- NCT04080102
- Testing
- High Intensity Interval Training, Essential Amino Acid, High intensity interval training and essential amino acid supplement
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Stage III Ovarian Epithelial Cancer, Stage III Ovarian Germ Cell Tumor
Vaccine Therapy in Treating Patients With Stage III-IV or Recurrent Ovarian Cancer
This phase I trial is studying the side effects of vaccine therapy in treating patients with stage III-IV or recurrent ovarian cancer.
- Conditions
- Stage III Ovarian Epithelial Cancer, Stage III Ovarian Germ Cell Tumor, Stage IV Ovarian Epithelial Cancer, Stage IV Ovarian Germ Cell Tumor
- Trial name
- NCT01322802
- Testing
- pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Washington
Protein Deposition
Protein Source on Plasma Amino Acid Concentrations In Older Adults
This study will determine the effect of the same ounce-equivalents of fresh pork versus nuts, beans, and eggs on postprandial plasma essential amino acid availability in older adults.
- Trial name
- S55 (NCT04243395)
- Testing
- Pork, Egg, Black beans
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University
Metastatic Colorectal Cancer
Medical Food for the Dietary Management of Metastatic Colorectal Cancer
This is a single arm study evaluating the tolerability and markers of colorectal cancer with a specially designed medical food restricted in specific amino acids for the dietary management of subjects with metastatic colorectal…
- Trial name
- NCT05183295
- Testing
- NEAAR Medical Food
- Sponsor
- Faeth Therapeutics
Exercise, Nutrition Therapy
Effects of Whey Protein and Collagen Supplementation
The present project aims to investigate the effects of high-quality protein (whey protein) vs. low-quality protein (collagen) on muscle mass and function (e.g., strength and power) during a 10-wk resistance training program in…
- Conditions
- Exercise, Nutrition Therapy, Resistance Training, Muscle Strength
- Trial name
- NCT04213586
- Testing
- Whey protein supplementation, Collagen supplementation
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidade Norte do Paraná
Energy Deficit
Effects of Essential Amino Acid-enriched Whey and Carbohydrate Co-ingestion on Protein Kinetics
Previous work conducted by the Investigators demonstrates that an essential amino acid(EAA)-enriched whey protein combination format is an efficient EAA/protein format to support enhanced whole-body protein balance and sustain…
- Trial name
- NCT04621175
- Testing
- EAA+W & Carbohydrate, EAA+W & EAA
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Schizophrenia
Gamma-Amino Butyric Acid (GABA)-A Alpha2/3 Study
The purpose of this research study is to determine whether a short-term administration of an investigational study drug may provide evidence of improvement in cognitive functioning in a group of stable male subjects with…
- Trial name
- NCT00129441
- Testing
- Merck L-830982
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Phenylketonurias
Amino Acid Kinetics of GMP-AA in Healthy Human Volunteers
Children with phenylketonuria (PKU) are treated with a special diet supplemented with a synthetic protein based on amino acids. These have a poor taste and are inefficiently used by the body.
- Trial name
- NCT05971563
- Testing
- Casein, L-amino acids, CGMP-AA
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Phenylketonuria
Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria
Patient suffering from phenylketonuria have chronic hyperphenylalaninemia. Hyperphenylalaninemia is known to be toxic to central nervous system and cardiovascular system in particular through oxydative stress.
- Trial name
- INGRAPH (NCT04879277)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cytomegalovirus Retinitis, HIV Infections
A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes
To determine whether alternating oral ganciclovir with intravenous ( IV ) ganciclovir can prevent relapse of Cytomegalovirus ( CMV ) retinitis and improve quality of life in AIDS patients.
- Trial name
- NCT00001062
- Testing
- Ganciclovir
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nicotine Dependence
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
The goal of this study is to examine the effects of a GABA (gamma amino butyric acid)-enhancing medication, pregabalin (300 mg/day), on smoking behavior, tobacco withdrawal and cigarette craving in smokers.
- Trial name
- NCT00644137
- Testing
- pregabalin, cigarettes
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Rectal Cancer
Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)
This clinical study aims to assess feasibility, safety, tolerability, and compliance of a Nonessential Amino Acid Restriction (NEAAR) medical food in adult patients with locally advanced rectal cancer during standard of care…
- Trial name
- NEAAR-LARC (NCT06380101)
- Testing
- NEAAR Medical Food
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of South Florida
Phenylketonuria
Low Phenylalanine Diet for Mothers With Phenylketonuria (PKU)
Phenylketonuria (PKU) is a rare genetic condition. If not treated, PKU can cause severe mental retardation. Women with PKU are advised to eat a special diet when pregnant to prevent mental retardation in their children.
- Trial name
- NCT00065299
- Testing
- Restricted phenylalanine diet
- Where
- 3 sites in United States
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Maple Syrup Urine Disease
Neurocognitive Outcomes and Quality of Life in Adults With Maple Syrup Urine Disease (MSUD)
Maple Syrup Urine Disease (MSUD) is a disorder of protein metabolism that leads to neurological differences. It is an exciting time where people diagnosed with MSUD are living longer.
- Trial name
- NCT04828863
- Testing
- Neurocognitive testing
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Non-small Cell Lung Cancer
Effects of Essential Amino Acid Intake on Net Protein Synthesis in Weight-losing Non-small Cell Lung Cancer Patients
Weight loss commonly occurs in lung cancer patients, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01172314
- Testing
- EAA+LEU vs total AA, Total AA vs EAA+LEU
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Non Alcoholic Fatty Liver Disease
The Effect Of Dual Treatment With L-Carnitine And Magnesium On Fatty Liver
The purpose of this study is to determine whether the dual therapy of the amino acid L-CARNITINE and magnesium have an effect on reducing the liver fat content in patients with non alcoholic fatty liver disease (NAFLD).
- Trial name
- NCT01956825
- Testing
- "slim water"
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
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