Clinical trials: Amino Acids
Cytomegalovirus Retinitis, HIV Infections
A Phase I Study of the Safety of Proleukin (Aldesleukin) in Combination With Ganciclovir and Antiretroviral Therapy in HIV Seropositive Patients With Cytomegalovirus (CMV) Retinitis
To determine the MTD and dose-limiting toxicities of a regimen of therapeutic ganciclovir, antiretroviral therapy, and recombinant interleukin-2 (aldesleukin; Proleukin) as an immune adjuvant in HIV-seropositive patients.
- Trial name
- NCT00002321
- Testing
- Aldesleukin
- Where
- United States
- Sponsor
- Chiron Corporation
Healthy
Glutamate Supplementation in Young Men
Amino acids play an important role in human metabolism. In aging individuals and in some diseases, certain amino acids, such as glutamate, are at lower than normal levels.
- Trial name
- NCT03425578
- Testing
- MSG, CHO
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
PKU, Tyrosinemias
GMP Case Studies of Tolerance, Safety and Acceptability in PKU and TYR
Three new protein substitutes have been developed to help with compliance in PKU and TYR patients, which are powdered protein substitutes, low in Phe and, low in Phe and Tyr respectively, with a mixed balance of glycomacropeptide…
- Trial name
- NCT05062226
- Testing
- PKU/TYR GMP Protein Substitute
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Nutricia UK Ltd
Growth
Growth and Tolerance of Young Infants
To compare growth and tolerance of healthy term infants fed two amino acid-based infant formulas.
- Trial name
- NCT03276884
- Testing
- Experimental Infant Formula, Control Infant Formula
- Where
- 22 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Fibromyalgia
L-Tyrosine Supplementation in Patients With Fibromyalgia
Patients in the study, who have a diagnosis of fibromyalgia, will be randomly assigned to take the amino acid L-tyrosine or placebo (blank pill) for 3 weeks.
- Trial name
- NCT01219049
- Testing
- Tyrosine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Iron-deficiency
Oral Lactoferrin Versus Iron Supplementation During Pregnancy
Iron deficiency anemia (IDA) is the condition in which there is anemia due to a lack of iron. The oral route is preferred to the parenteral route to replace iron stores [Sharma JB; et al., 2004].
- Trial name
- NCT03542825
- Testing
- Lactoferrin, Iron Supplement, Chelates, Iron
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- South Valley University
Phenylketonuria
Phenylalanine and Its Impact on Cognition
The PICO-Study is a randomized, placebo-controlled, crossover, non-inferiority trial conducted to add evidence to the current European treatment guidelines for adult patients with phenylketonuria.
- Trial name
- PICO (NCT03788343)
- Testing
- Phenylalanine
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Phenylketonuria, PAH Deficiency
Long-Term Follow Up Study of Subjects Previously Administered HMI 102
An Open-Label, Long-Term Follow Up Study of Safety and Efficacy in PKU Subjects with PAH Deficiency Previously Administered HMI 102
- Trial name
- NCT04348708
- Testing
- HMI-102
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Homology Medicines, Inc
Schizophrenia, Mental Disorders
Effects of Delta-9-THC and Iomazenil in Healthy Humans
The study aims to examine the combined effects of delta-9-tetrahydrocannabinol (∆-9-THC or THC) and iomazenil on thinking, perception, mood, memory, attention, and electrical activity of the brain (EEG).
- Conditions
- Schizophrenia, Mental Disorders, Psychotic Disorders
- Trial name
- NCT00982982
- Testing
- THC and Iomazenil
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Yale University
Ulcerative Colitis
Amino Acids in Ileal Pouch-anal Anastomosis for Ulcerative Colitis
The detrimental effects of catabolism, insuline resistance and muscle wasting on surgical outcome is wellknown. This catabolism is especially pronounced in patients with acute or chronic inflammation (IBD, cancer) and for those…
- Trial name
- AMINOPOUCH (NCT02084550)
- Testing
- Vaminolac, Saline
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Aarhus University Hospital
Skin Photoaging
Efficacy and Tolerance Evaluation of an Amino Acid Food Supplement
Skin moisturizing and elasticizing efficacy of an amino acid food supplement
- Trial name
- NCT03801343
- Testing
- Nutrakos®
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Propionic Acidemia, Methylmalonic Acidemia
Long-term Outcome of N-Carbamylglutamate Treatment in Propionic Acidemia and Methylmalonic Acidemia
Background: Very few drugs exist that treat hyperammonemia, specifically PA and MMA. Diet restrictions and alternate pathway agents are the current primary treatments, but they frequently fail to prohibit brain damage.
- Trial name
- NCT01597440
- Testing
- N-carbamylglutamate, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mendel Tuchman
Exercise Myoglobinuria, Citrulline; Metabolic Disorder
Supplementation With Altha-aminoacids and Systemiec Inflammatory Response in Long-distance Runners.
It is also noteworthy that the imbalance between the production, supply and elimination of especially α-amino acids may contribute to the intensification of the inflammatory response and the subsequent burden of the renal…
- Conditions
- Exercise Myoglobinuria, Citrulline; Metabolic Disorder, Iron Metabolism Disorders, Inflammatory Response
- Trial name
- NCT05510440
- Testing
- Alpha-amino acid derivatives
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Normal Physiology
MRS Measurement of Glutamate and GABA Metabolism in Brain
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters.
- Trial name
- NCT00109174
- Testing
- 3T and 7T device
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Lumbar Spinal Stenosis
Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial
The goal of this clinical trial is to prospectively evaluate the effects of essential amino acid (EAA) supplementation on the volume and structure of the muscles surrounding the spine (paraspinal musculature).
- Trial name
- NCT06579391
- Testing
- Essential amino acids, Alanine
- Where
- United States
- Sponsor
- University of California, Irvine
Phenylketonuria
SNAP: Study Nutrients in Adult PKU
Phenylketonuria (PKU) is a rare inherited metabolic disorder, where subjects are born with a genetic deficiency in the phenylalanine hydroxylase enzyme (PAH), which leaves them unable to convert Phenylalanine (Phe) into Tyrosine…
- Trial name
- SNAP (NCT03858101)
- Where
- 4 sites in Belgium, Denmark and 1 more
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
This multi-centric study analyses the effect of intravenous branched-chain amino acids (BCAA) on overt HE in patients with ACLF.
- Trial name
- NCT05700695
- Testing
- Branch Chain Amino Acid, Lactulose
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Phenylketonurias
Life With Phenylketonuria. Adult Neurological Outcome of PCU Screened Patients From 1971 to 2002.
You were detected during the neonatal period for phenylketonuria and you benefited from the diagnosis of an adapted dietetic care, and this for a variable duration according to the recommendations followed at that time.
- Trial name
- PCU (NCT04433728)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Lille
Hepatic Insufficiency
Study of the Safety and Tolerability of AXA1665 in Subjects With Mild and Moderate Hepatic Insufficiency
This is a randomized, single blind study to determine whether AXA1665, a composition of naturally occuring amino acids, is well tolerated in subjects with mild and moderate hepatic insufficiency.
- Trial name
- NCT04147936
- Testing
- AXA1665
- Where
- 11 sites in United States
- Volunteers
- 60 people
- Sponsor
- Axcella Health, Inc
Alcoholic Liver Disease, COVID 19 Pneumonia
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD) are at risk for severe illness and abrupt or sudden clinical deterioration with ventilatory failure.
- Trial name
- NCT04858412
- Testing
- β-hydroxy β-methyl butyrate (HMB) enriched amino acid, Balanced amino acid
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cleveland Clinic
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