Clinical trials: Amino Acids
Schizo-affective Disorder, Bipolar Disorder
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders
The purpose of this study is to assess the efficacy of oral glycine as an augmentation strategy in two psychotic patients with a triplication (4 copies) of the gene glycine decarboxylase (GLDC).
- Trial name
- NCT01720316
- Testing
- Glycine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mclean Hospital
Healthy, Men
Metabolic Availability of Lysine From Wheat in Adult Men
Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins.
- Trial name
- NCT03200652
- Testing
- Metabolic availability of lysine in wheat
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Plasma Amino Acid Appearance and Disappearance, Postprandial Metabolic Events
Effects of Pea Proteins With Different Degrees of Processing on Postprandial Metabolism in Healthy Adults
The aim of this study is to investigate the postprandial metabolic responses to plant-based protein ingredients of different degrees of processing (pea protein concentrate, isolate, and extrudate) and in comparison to whey…
- Trial name
- NCT06155656
- Testing
- Pea protein concentrate, Pea protein isolate, Pea protein extrudate
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Critical Illness, Inflammation
Amino Acid Nutrition in the Critically-ill
Enhancing the anabolic effect of nutrition in critically ill patients by administering exogenous amino acids.
- Conditions
- Critical Illness, Inflammation, Malnutrition
- Trial name
- AA-ICU (NCT02865408)
- Testing
- Peptamen 1.5% via enteral, Prosol 20% IV to 1.75g/kg/day, Prosol 20% IV to 2.5g/kg/day
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Arnold Kristof
Short Bowel Syndrome
Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome
This study will assess the tolerability and palatability of an amino acid based oral rehydration solution (enterade®) compared to current oral rehydration solution among children with short bowel syndrome .
- Trial name
- NCT03105362
- Testing
- Enterade® oral rehydration solution
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital
Dietary Proteins
Determining the Effect of Protein Quality on Post-exercise Anabolism in Active Youth
Leucine-enriched proteins (e.g., dairy) are more effective than plant-based sources for supporting post-exercise rates of muscle protein synthesis in adults.
- Trial name
- PQS (NCT05052827)
- Testing
- Milk Protein Concentrate, Rice Protein Isolate, Soy Protein Isolate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stunted Growth
Amino Acid Supplementation in Children with Stunting
The goal of this intervention study is to determine the effects of indispensable amino acid (IAA) supplementation on children of either sex, aged 18 to 36 months.
- Trial name
- NCT06676215
- Testing
- IAA mix supplement, Complementary food comprised of rice and legumes
- Where
- Philippines
- Volunteers
- 60 people
- Sponsor
- Food and Nutrition Research Institute, Philippines
Urea Cycle Disorders
Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle Disorders
This was a randomized, active-controlled, double-blind, cross-over study designed to enroll subjects with UCDs who are being treated with NaPBA.
- Trial name
- NCT00992459
- Testing
- HPN-100, Buphenyl (NaPBA)
- Where
- 22 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Amgen
Peri-Implant Health, Peri Implant Mucositis
Free Amino-acid Composition of Peri-implant and Periodontal Conditions
Peri-implant diseases, encompassing peri-implant mucositis and peri-implantitis, are biologically driven inflammatory conditions that threaten the long-term success of dental implants.
- Conditions
- Peri-Implant Health, Peri Implant Mucositis, Peri Implantitis
- Trial name
- AAs (NCT07187323)
- Testing
- Saliva sampling, Amino Acid Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Branched-chain Amino Acid Metabolism, Insulin Sensitivity
Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes
Elevated circulating levels of certain amino acids (the building blocks of protein) are strongly associated with insulin resistance.
- Trial name
- BCAAM-PD (NCT01786941)
- Testing
- Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training, GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Duke University
Malnutrition, Sarcopenia
Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress…
- Trial name
- MIMOSA (NCT05324475)
- Testing
- BCAA, Micronutriments
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Patrizia D'Amelio
Amino Acid Metabolism, Inborn Errors
Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders
OBJECTIVES: I. Assess the safety and efficacy of sodium phenylbutyrate, sodium benzoate, sodium phenylacetate, and dietary intervention in patients with urea cycle disorders.
- Trial name
- NCT00004767
- Testing
- Sodium Benzoate, Sodium Phenylacetate, Sodium Phenylbutyrate
- Volunteers
- 20 people
- Sponsor
- National Center for Research Resources (NCRR)
Brain Metastases, Brain Metastases, Adult
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
This is a pilot imaging study in participants treated with stereotactic radiosurgery (SRS) to treat brain metastasis. The purpose of this study is to see whether 18F-Fluciclovine positron emission tomography (PET) can be used as…
- Conditions
- Brain Metastases, Brain Metastases, Adult, Brain Cancer
- Trial name
- FACILITATE (NCT06048094)
- Testing
- 18F fluciclovine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Baptist Health South Florida
Phenylketonurias, Cardiovascular Diseases
A Study Into the Future Cardiovascular Disease (CVD) Risk of Phenylketonuria (PKU) Patients on a Low Phenylalanine Treatment Diet (LPD).
This study will assess the cardiovascular disease (CVD) risk in Phenylketonuria (PKU) patients on a low-phenylalanine diet (LPD).
- Trial name
- NCT04251494
- Testing
- Carotid intima media thickness measurement (CIMT), Pulse Wave Velocity measurement, Ankle-brachial pressure index (ABPI)
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Healthy
Validation of the Dual-isotope Method for Measuring Ileal Protein Digestibility
The dual isotope method has been recently developed and used to evaluate indispensable amino acid (IAA) digestibility of various protein food such as legumes, eggs and chicken meat in healthy adults and children.
- Trial name
- VALDIM (NCT05426551)
- Testing
- Dual isotope method
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Liver Cirrhosis
Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease
Protein-calorie malnutrition is frequently observed in patients with advanced liver cirrhosis. There have been continued interests in potential benefits of long-term oral branched-chain amino acid supplement in improving severity…
- Trial name
- BRAVE (NCT02837302)
- Testing
- Livact
- Where
- South Korea
- Volunteers
- 1,470 people
- Sponsor
- Kyungpook National University Hospital
Inborn Errors of Metabolism, Pregnancy
Maternal Inborn Errors of Metabolism in Pregnancy: A Pregnancy Registry Protocol
Background: People with inborn errors of metabolism can t turn food into energy the right way. This can affect a person s growth and health. Researchers want to know how this condition affects a pregnant woman and her baby.
- Conditions
- Inborn Errors of Metabolism, Pregnancy, Acidemias
- Trial name
- NCT02322177
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Urea Cycle Disorders
Dose-Escalation Safety Study of HPN-100 to Treat Urea Cycle Disorders
The purpose of this study is to determine whether HPN-100 is safe and tolerable in subjects with Urea Cycle Disorders.
- Trial name
- NCT00551200
- Testing
- HPN-100, BUPHENYL®
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Amgen
Phenylketonurias
Evaluation of Low Phenylalanine Formulas
Ajinomoto Cambrooke has developed a PKU protein substitute that is a proprietary blend of purified Glycomacropeptide (GMP) and essential amino acids, under the brand name Glytactin®.
- Trial name
- NCT06332105
- Testing
- Glytactin, L-AA
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Ajinomoto Co., Inc.
Brain Metastases, Brain Cancer
Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis
This study is for patients who have had surgery to remove brain metastasis and are planned to have stereotactic radiosurgery (SRS) after their brain surgery.
- Trial name
- CONCORDANT (NCT05554302)
- Testing
- 18F-Fluciclovine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baptist Health South Florida
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