Clinical trials: Amino Acids
Cytomegalovirus Infections, HIV Infections
Ganciclovir: Compassionate Use in Patients With Serious or Life-Threatening Cytomegalovirus Infections
To provide ganciclovir on a compassionate use basis to immunocompromised patients with serious cytomegalovirus (CMV) infections and to study safety and efficacy in this patient population.
- Trial name
- NCT00002024
- Testing
- Ganciclovir
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Cow Milk Allergy
Mineral Status Ininfants With Cow's Milk Protein Allergy
This study evaluate the mineral status of infants with cow's milk protein allergy which is affected due to the elimination of milk , and the change in this mineral status after receiving amino acid - based formula for 12 weeks.
- Trial name
- NCT04327297
- Testing
- Amino acid-based formula
- Volunteers
- 40 people
- Sponsor
- Assiut University
Healthy, Type 2 Diabetes
Forearm Immobilization in T2D
The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with…
- Trial name
- FIT2D (NCT06750497)
- Testing
- Forearm immobilization
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Hyperlipidemias, Metabolic Syndrome X
Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers
The aim of this study is to explore the significance of the Lys:Arg ratio on responses of lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of dietary Lys:Arg on cardiovascular disease risk…
- Conditions
- Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases
- Trial name
- NCT00175084
- Testing
- Comparison of dietary protein amino acid profile
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
AADC Deficiency
A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients
The overall objective of this study is to determine the safety and efficacy of AAV2-hAADC delivered to the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in children with aromatic L-amino acid decarboxylase…
- Trial name
- AADC (NCT02852213)
- Testing
- AAV2-hAADC
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Krzysztof Bankiewicz
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Pre-diabetes, Obesity
Project Plant Protein: the P3 Study in Humans
The objective of this study is to compare the effects of adding three plant-based proteins (rice, oats and pea proteins) to a breakfast beverage on the glycemic response, appetite and subsequent food intake of healthy adults.
- Trial name
- NCT02933424
- Testing
- Protein Powder
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Hypertension
A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
The purpose of this study is to determine whether 6R-BH4 (sapropterin dihydrochloride) is safe and effective in the treatment of poorly controlled hypertension in the presence or absence of type 2 diabetes.
- Trial name
- NCT00325962
- Testing
- 6R-BH4 (sapropterin dihydrochloride)
- Where
- 24 sites in United States
- Volunteers
- 84 people
- Sponsor
- BioMarin Pharmaceutical
Oral Hemorrhage
Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients
Patients using anticoagulants present an increased risk of bleeding when subjected to oral surgery. Suspending or reducing the oral anticoagulant dose to perform invasive procedures, may result in thromboembolic events, putting…
- Trial name
- NCT02238288
- Testing
- Aminocaproic acid, Routine dental care, lidocaine and epinephrine
- Where
- Brazil
- Volunteers
- 154 people
- Sponsor
- Grupo de Estudos Multicentricos em Onco-Hematologia
Homocystinuria
Betaine METABOLISM OF PATIENTS With Homocystinuria
Oral treatment with betaine is conventionally used for patients with inherited homocystinurias. These conditions include a first group of patients with a cystathionine β-synthase (CBS) deficiency and a second group of patients…
- Trial name
- HCTBETAINE (NCT02404337)
- Testing
- Betaine
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amino Acid Absorption, Amino Acid Plasma Profile
Spoonable Bioavailability
The key research objective is to characterise the amino acid (AA) bioavailability for 4 hours following consumption of a single serving of a high protein spoonable yoghurt, compared to a micellar casein drink or a flavoured…
- Conditions
- Amino Acid Absorption, Amino Acid Plasma Profile, Amino Acids, Essential
- Trial name
- BOLT_Part A (NCT06733142)
- Testing
- Test Product: Yoghurt, Micellar casein drink
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Glyn Howatson
Phenylketonuria (PKU)
The Impact of Frequency of Home Phenylalanine Measurements on Metabolic Control in a Population of Patients With Classic Phenylketonuria
Recommendations regarding the frequency of phenylalanine level monitoring lack solid support from evidence derived from prospective randomized trials, including in the adult population with classic PKU.
- Trial name
- FreqPHEncy (NCT07825883)
- Testing
- DBS Phe monitoring once weekly, DBS Phe monitoring once monthly
- Where
- Poland
- Volunteers
- 36 people
- Sponsor
- Michał Kania
Tendinopathy
Can Amino Acid Supplementation Augment the Anabolic Response in Tendon After Exercise
The goal of this study is to determine if an oral provision of amino acids will enhance exercise-induced increases in markers of Achilles tendon collagen production.
- Trial name
- NCT04067479
- Testing
- Amino Acids
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Purdue University
Cytomegalovirus Retinitis, HIV Infections
CMV Retinitis Retreatment Trial
To assess the safety and efficacy of three therapeutic regimens (foscarnet, ganciclovir, or the combination) for recurrent or persistent AIDS-related cytomegalovirus (CMV) retinitis.
- Trial name
- NCT00000766
- Testing
- Foscarnet sodium, Ganciclovir
- Where
- 9 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Diseases, Hepatic Encephalopathy
Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy Subjects
The purpose of this study is to determine whether Branched chain Amino Acids enhances the uptake of ammonia in muscle tissue.
- Conditions
- Liver Diseases, Hepatic Encephalopathy, Hepatic Insufficiency
- Trial name
- NCT00931060
- Testing
- Branched chain amino acids
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy, Type 2 Diabetes
Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion
This study is being done to better understand how amino acids alter the release of glucagon and insulin compared to glucose alone in health and disease.
- Conditions
- Healthy, Type 2 Diabetes, Obesity
- Trial name
- NCT05264727
- Testing
- Dextrose, Clinisol 15%
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Urea Cycle Disorder, Crigler-Najjar Syndrome
HepaStem Long-Term Safety Registry
All patients having received at least one infusion of the Investigational Medicinal Product (IMP) HepaStem HHALPC during a previous interventional clinical study conducted by Promethera Biosciences
- Conditions
- Urea Cycle Disorder, Crigler-Najjar Syndrome, Acute on Chronic Liver Failure
- Trial name
- PROLONGSTEM (NCT03343756)
- Where
- 29 sites in Belgium, Bulgaria and 3 more
- Volunteers
- 44 people
- Sponsor
- Cellaion SA
Prostate Cancer
FACBC Prostate Therapy Response
The purpose of this study is to assess if using anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (FACBC or fluciclovine) PET scan will be useful in determining if participants are responding to chemotherapy treatment.
- Trial name
- NCT02830880
- Testing
- FACBC PET-CT, MRI, CT, or Bone Scan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Emory University
Ovarian Cancer
Evaluation of Amino Acid Metabolism Changes in Ovarian Cancer
Ovarian cancer is associated with undernutrition in more than half of all cases. The current management of undernutrition-cachexia in cancer is not specific.
- Trial name
- AMINOCANCER (NCT06216496)
- Testing
- dynamic test for amino acid metabolism
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
AADC Deficiency
A Study of SmartFlow Magnetic Resonance (MR) Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Participants
This study will have a trial phase, extension phase, and a long-term extension phase. The primary objectives of the trial phase are to assess the pharmacodynamics (PD) of eladocagene exuparvovec treatment by evaluation of…
- Trial name
- NCT04903288
- Testing
- Eladocagene Exuparvovec
- Where
- 6 sites in United States, Israel and 1 more
- Volunteers
- 13 people
- Sponsor
- PTC Therapeutics
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